Results 71 to 80 of about 4,965 (233)

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, Volume 21, Issue 29, July 24, 2025.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

Diazonium Salts in Visible Light Photocatalysis – a Focused Overview of their Application in Continuous Flow Synthesis

ChemPhotoChem, Volume 9, Issue 6, June 2025.
The combination of continuous flow technology and visible light photocatalysis has been used to improve the safety and productivity of reactions with diazonium salts as reactive intermediates. This approach has proven to be a reliable method for various organic synthesis routes with diazonium salts under mild and well‐defined conditions.
Christoph Deckers, Thomas H. Rehm
wiley   +1 more source

Analysis of the flavonoid component of bioactive New Zealand mānuka (Leptospermum scoparium) honey and the isolation, characterisation and synthesis of an unusual pyrrole [PDF]

, 2013
The flavonoid components of New Zealand mānuka (Leptospermum scoparium) honey have been quantified in a series of 31 honeys of varying non-peroxide antibacterial activity to clarify discrepancies between previous studies reported in the literature. Total
Alber, Dagmar G., Chan, Ching Wan, Deadman, Benjamin Jade, Harry, Elizabeth, Manley-Harris, Merilyn, Wilkins, Alistair L.   +5 more
core   +2 more sources

Systemic Primary Carnitine Deficiency Presenting With Substantia Nigra and Basal Ganglia Injury: A Case Report

JIMD Reports, Volume 66, Issue 3, May 2025.
ABSTRACT Systemic primary carnitine deficiency (SPCD) is a rare congenital fatty acid metabolism disorder causing impaired β‐oxidation and energy production, leading to hypoglycemia, metabolic encephalopathy, and sudden death. Early diagnosis and treatment, including L‐carnitine supplementation and fasting avoidance, can improve prognosis.
Tomoki Saito, Kento Soma, Mai Kashisaka, Kiiko Iketani, Masaaki Matsumoto, Takuya Ueda, Masahiro Nishiyama, Azusa Maruyama, Ryosuke Nakai, Hiroshi Sakihama, Hiroshi Kurosawa, Naoya Morisada, Hironori Kobayashi, Kayo Ozaki   +13 more
wiley   +1 more source

Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication [PDF]

, 2014
Paraoxon (POX) is an active metabolite of organophosphate (OP) pesticide parathion that has been weaponized and used against civilian populations. Exposure to POX produces high mortality.
Blair, Robert E., Carter, Dawn S., DeLorenzo, Robert J., Deshpande, Laxmikant Sudhir, Phillips, Kristin   +4 more
core   +2 more sources

Effect of Dantrolene Sodium on Calcium-Overloaded Heart

Japanese Circulation Journal, 1997
Spontaneous asynchronous contractile activity caused by spontaneous release of calcium ions (Ca2+) from the sarcoplasmic reticulum (SR) is thought to be the cause of deterioration of ventricular function under conditions of calcium overload. We examined whether dantrolene sodium, which can inhibit Ca2+ release from the skeletal SR, improves the ...
Nobumasa Ishide, Masuko Satoh, Yutaka Kagaya, Tsuyoshi Shinozaki, Kunio Shirato   +4 more
openaire   +4 more sources

Mitochondria regulate inositol triphosphate‐mediated Ca2+ release triggered by voltage‐dependent Ca2+ entry in resistance arteries

The Journal of Physiology, Volume 603, Issue 10, Page 2959-2978, 15 May 2025.
Abstract figure legend Proposed mechanism of regulation of mitochondria on VDCCs mediated Ca2+ signals in smooth muscle cells. Depolarization of the plasma membrane induces Ca2+ influx via L‐type VDCCs that produces a steady elevation in Ca2+ and activates IP3Rs to evoke repetitive Ca2+ release events from the intracellular Ca2+ store.
Xun Zhang, Charlotte Buckley, Matthew D. Lee, Susan Chalmers, Calum Wilson, John G. McCarron   +5 more
wiley   +1 more source

Antidote Stocking at Hospitals in North Palestine [PDF]

, 2007
Objective: The purpose of this study was to determine the availability and adequacy of antidote stocking at hospitals in north Palestine based on published guidelines for antidote stocking.
Al-Jabi W, Samah, Sawalha F, Ansam, Sweileh M, Waleed, Zyoud H, Sa'ed   +3 more
core   +1 more source

Computational analysis of calcium signaling and membrane electrophysiology in cerebellar Purkinje neurons associated with ataxia [PDF]

, 2012
BACKGROUND: Mutations in the smooth endoplasmic reticulum (sER) calcium channel Inositol Trisphosphate Receptor type 1 (IP3R1) in humans with the motor function coordination disorders Spinocerebellar Ataxia Types 15 and 16 (SCA15/16) and in a ...
Leslie M Loew, Sherry-Ann Brown
core   +2 more sources

Recognizing and managing a malignant hyperthermia crisis: guidelines from the European Malignant Hyperthermia Group [PDF]

, 2017
Survival from a malignant hyperthermia (MH) crisis is highly dependent on early recognition and prompt action. MH crises are very rare and an increasing use of total i.v.
Ellis, F. R., Glahn, K. P. E., Halsall, P. J., Müller, C. R., Snoeck, M. M. J., Urwyler, A., Wappler, F.   +6 more
core