Results 51 to 60 of about 2,485 (155)

The cost-effectiveness of multi-purpose HIV and pregnancy prevention technologies in South Africa. [PDF]

, 2018
INTRODUCTION: A number of antiretroviral HIV prevention products are efficacious in preventing HIV infection. However, the sexual and reproductive health needs of many women extend beyond HIV prevention, and research is ongoing to develop multi-purpose ...
Cabrera Escobar, Maria A, Delany-Moretlwe, Sinead, Eakle, Robyn, Kilbourne-Brook, Maggie, Meyer-Rath, Gesine, Mvundura, Mercy, Quaife, Matthew, Terris-Prestholt, Fern, Vickerman, Peter   +8 more
core   +1 more source

Clinical testing of antiretroviral drugs as future prevention against vaginal and rectal transmission of HIV infection – a review of currently available results

Acta Pharmaceutica, 2019
The original purpose of vaginally applied microbicides was to slow down the HIV epidemic among the population until an effective vaccination was developed.
Vysloužil Jakub, Kubová Kateřina, Tkadlečková Veronika Nováková, Vetchý David   +3 more
doaj   +1 more source

Characteristics of Women Enrolled into a Randomized Clinical Trial of Dapivirine Vaginal Ring for HIV-1 Prevention.

PLoS ONE, 2015
IntroductionWomen in sub-Saharan Africa are a priority population for evaluation of new biomedical HIV-1 prevention strategies. Antiretroviral pre-exposure prophylaxis is a promising prevention approach; however, clinical trials among young women using ...
Thesla Palanee-Phillips, Katie Schwartz, Elizabeth R Brown, Vaneshree Govender, Nyaradzo Mgodi, Flavia Matovu Kiweewa, Gonasagrie Nair, Felix Mhlanga, Samantha Siva, Linda-Gail Bekker, Nitesha Jeenarain, Zakir Gaffoor, Francis Martinson, Bonus Makanani, Sarita Naidoo, Arendevi Pather, Jessica Phillip, Marla J Husnik, Ariane van der Straten, Lydia Soto-Torres, Jared Baeten   +20 more
doaj   +1 more source

Preferences for ARV-based HIV prevention methods among men and women, adolescent girls and female sex workers in Gauteng Province, South Africa: a protocol for a discrete choice experiment. [PDF]

, 2016
INTRODUCTION: For the past few decades, condoms have been the main method of HIV prevention. Recent advances in antiretroviral (ARV)-based prevention products have substantially changed the prevention landscape, yet little is known about how popular ...
Cabrera, Maria, Cianci, Fiona, Delany-Moretlwe, Sinead, Eakle, Robyn, Quaife, Matthew, Terris-Prestholt, Fern, Tsepe, Motlalepule, Vickerman, Peter   +7 more
core   +3 more sources

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite, Fernando B. Macedo, Murilo Marinho de C. Lima, Isabelle S. Brum, Jonathan Fragoso Miranda de Oliveira, Ana Clara S. Costa, Stella C. Duarte, Sarah Moon, Stefany de Castro B. Moura, Andressa P. de Oliveira, Nubia Boechat, Monica M. Bastos   +11 more
wiley   +1 more source

Evaluation of polycaprolactone matrices for the intravaginal delivery of metronidazole in the treatment of bacterial vaginosis [PDF]

, 2014
Microporous, poly (ε-caprolactone) (PCL) matrices loaded with the antibacterial, metronidazole were produced by rapidly cooling suspensions of drug powder in PCL solutions in acetone. Drug incorporation in the matrices increased from 2.0% to 10.6% w/w on
Coombes, Allan G. A., Palmer, Cheryn, Pathak, Meenakshi, Turner, Mark   +3 more
core   +1 more source

Traditional health practitioners’ management of HIV/AIDS in rural South Africa in the era of widespread antiretroviral therapy [PDF]

, 2017
Background: Traditional health practitioners (THPs) have been identified as a key local resource in the fight against HIV/AIDS in South Africa. However, their approaches to the treatment of people living with HIV (PLHIV) have been met with skepticism by ...
Moshabela, Mosa, Rochat, Tamsen, Wight, Daniel, Zuma, Thembelihle   +3 more
core   +1 more source

Mechanism‐Based Predictions of Local Tissue and Systemic Exposure for Drug Products Delivered Through the Female Reproductive Tract

The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.
Abstract Effective drug delivery through the female reproductive tract (FRT) presents unique challenges due to the lack of robust predictive models for drug exposure via this route. Addressing this gap, we developed and evaluated a comprehensive whole‐body physiologically based pharmacokinetic (PBPK) model that incorporates anatomical and physiological
Xinnong Li, Thomas Straubinger, Lisa C. Rohan, Sharon L. Achilles, Beatrice A. Chen, Guru Valicherla, Zhongfang Zhang, Mark Donnelly, Eleftheria Tsakalozou, Liang Zhao, Robert Bies   +10 more
wiley   +1 more source

Evolving landscape of economic evaluations of HIV pre‐exposure prophylaxis and pre‐exposure prophylaxis implementation strategies: a systematic review

Journal of the International AIDS Society, Volume 28, Issue 11, November 2025.
Abstract Introduction Economic evaluations of HIV pre‐exposure prophylaxis (PrEP) and associated implementation strategies guide evidence‐based policies, programmes and resource allocation. Since 2015, there has been an evolution in PrEP modalities, implementation strategies and prioritization of key populations with unmet HIV prevention needs ...
Min Xi, Darrell H. S. Tan, Stefan D. Baral, Howsikan Kugathasan, Lisa Masucci, Becky Skidmore, Derek R. MacFadden, Kednapa Thavorn, Sharmistha Mishra   +8 more
wiley   +1 more source

Evaluating the potential impact and cost-effectiveness of dapivirine vaginal ring pre-exposure prophylaxis for HIV prevention.

PLoS ONE, 2019
BackgroundExpanded HIV prevention options are needed to increase uptake of HIV prevention among women, especially in generalized epidemics. As the dapivirine vaginal ring moves forward through regulatory review and open-label extension studies, the ...
Meghan Reidy, Elizabeth Gardiner, Carel Pretorius, Robert Glaubius, Kristine Torjesen, Katharine Kripke   +5 more
doaj   +1 more source