Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors [PDF]
, 2018 Indolylarylsulfones are a potent class of human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors. In this review, the structure activity relationship (SAR) studies to improve the profile of sulfone L-737,126 discovered by ...
Famiglini, V., Silvestri, R.
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Recent advances in pre-exposure prophylaxis for HIV [PDF]
, 2017 Although pre-exposure prophylaxis (PrEP)-the use of antiretroviral drugs by non-infected people to prevent the acquisition of HIV-is a promising preventive option, important public health questions remain.
Desai, M +3 more
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Long-Acting Anti-HIV Drugs Targeting HIV-1 Reverse Transcriptase and Integrase
Pharmaceuticals, 2019 One of the major factors contributing to HIV-1 drug resistance is suboptimal adherence to combination antiretroviral therapy (cART). Currently, recommended cART for HIV-1 treatment is a three-drug combination, whereas the pre-exposure prophylaxis (PrEP ...
Kamal Singh +2 more
doaj +1 more source
Preventing HIV Infection in Women: A Global Health Imperative [PDF]
, 2010 Women account for approximately one-half of all human immunodeficiency virus (HIV) infections worldwide. Sexual transmission is the dominant mode of HIV transmission to women, and there is a concomitant associated epidemic of transmission to infants. The
Abdool Karim, Quarraisha +2 more
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Liposome‑delivered baicalein induction of myeloid leukemia K562 cell death via reactive oxygen species generation [PDF]
, 2018 Baicalein (BL), a potential cancer chemopreventative flavone, has been reported to inhibit cancer cell growth by inducing apoptosis and causing cell cycle arrest in various human cancer cell models.
Berger +52 more
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BMC Women's Health, 2021 Background Clinical trials have found that a monthly dapivirine vaginal ring was well-tolerated and reduced HIV-1 risk among women in sub-Saharan Africa.
Jonah Leslie +10 more
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Highlights from the 9th IAS conference on HIV science, 23-26 July 2017, Paris, France [PDF]
, 2017 The 9th International AIDS Society Conference on HIV Science (IAS 2017) took place at the Palais des Congrès, in Paris, France, from 23 to 26 July 2017, chaired by Linda-Gail Bekker and Jean-François Delfraissy. It was organised by the International AIDS
Barber, Tristan J +3 more
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Bacterial biofilms in the vagina [PDF]
, 2017 A bacterial biofilm is a structured community of bacteria in a self-produced extracellular matrix, adherent to an inert surface or biological tissue. The involvement of biofilm in a bacterial infection implies that the infection is difficult to treat and
Cerca, Nuno +4 more
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Seizing the moment: the potential of PrEP choice and innovation to transform HIV prevention
Journal of the International AIDS Society, Volume 28, Issue S2, July 2025.Abstract Introduction The potential of pre‐exposure prophylaxis (PrEP), as a highly effective and empowering HIV prevention intervention, has not yet been realized. Despite the recent acceleration in the scale‐up of oral PrEP, there is a substantial unmet PrEP need, and the world is not on track to meet the 2025 prevention targets.
Heather‐Marie A. Schmidt +6 more
wiley +1 more source
CCR5 antagonists used as topical microbicides modulate CCR5 expression and may potentially compound HIV infection [PDF]
, 2017 CCR5 antagonists, such as Maraviroc (MVC) and 5P12-RANTES, are being evaluated as HIV preventatives. The advantage of these drugs is that they restrict HIV entry via CCR5 receptor.
Laux, Julie
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