Results 1 to 10 of about 1,789 (171)

Safety, Acceptability and Adherence of Dapivirine Vaginal Ring in a Microbicide Clinical Trial Conducted in Multiple Countries in Sub-Saharan Africa. [PDF]

PLoS ONE, 2016
BackgroundThis was the first microbicide trial conducted in Africa to evaluate an antiretroviral-containing vaginal ring as an HIV prevention technology for women.ObjectivesThe trial assessed and compared the safety, acceptability and adherence to ...
Annalene Nel, Linda-Gail Bekker, Elizabeth Bukusi, Elizabeth Hellstrӧm, Philip Kotze, Philip Kotze, Cheryl Louw, Francis Martinson, Gileard Masenga, Elizabeth Montgomery, Nelisiwe Ndaba, Ariane van der Straten, Neliëtte van Niekerk, Cynthia Woodsong   +13 more
doaj   +6 more sources

A mixed-method study of feasibility and acceptability of the Dapivirine vaginal ring among adolescent girls and young women (AGYW) in selected Zimbabwean districts. [PDF]

PLOS Global Public Health
The Dapivirine vaginal ring (DPV-VR) is an intravaginal silicone ring that delivers an antiretroviral drug (Dapivirine) directly to vaginal tissues for 28 days.
Noah Taruberekera, Malvern Munjoma, Owen Mugurungi, Getrude Ncube, Miriam Mutseta, Munyaradzi Dhodho, Hanul Choi, Jabulani Mavudze, Tafara Moga, Blessing Mutede   +9 more
doaj   +3 more sources

Adherence to the Dapivirine Vaginal Ring Among Cisgender Women in Africa: Protocol for a Systematic Review and Meta‐Analysis [PDF]

Health Science Reports
Background and Aims Despite the availability of HIV preventive measures, new HIV infections are still on the rise. The Dapivirine Vaginal Ring (DVR) is a silicone circular ring that continuously distributes 25 mg of Dapivirine into a woman's vagina for ...
Roseline Dzekem Dine, Giulia Muraca, Behnam Sadeghirad, Lawrence Mbuagbaw   +3 more
doaj   +2 more sources

Self-reported removal and expulsion of the dapivirine vaginal ring: qualitative reports from female ring users and their male partners in the Ring Study (IPM 027) [PDF]

BMC Public Health
Background/aims The dapivirine vaginal ring is a self-administered, women-initiated, discreet, long-acting HIV-1 prevention option for women. It was found to be safe and effective in healthy HIV-negative women who adhered to product use instructions, and
Cecilia Milford, Hariska Ramlal, Rorisang Mofokeng, Letitia Rambally Greener, Annaléne Nel, Jennifer Smit, Mariëtte Malherbe   +6 more
doaj   +2 more sources

Exploring pregnant women’s experiences with dapivirine vaginal ring insertion during the MTN-042/DELIVER study in Uganda: a description of secondary data [PDF]

Therapeutic Advances in Infectious Disease
Background: Involving pregnant women in HIV prevention trials is key to ensuring that they benefit from efficacious products. MTN-042/DELIVER was a phase IIIb, open-label, multi-site, randomized safety study, the first of its kind to enroll HIV-negative ...
Joselyne Nansimbe, Brenda Gati Mirembe, Phionah Kibalama Ssemambo, Annette Miwanda Ssekasi, Rose Byogero, Justine Nalwoga, Clemensia Nakabiito   +6 more
doaj   +2 more sources

The impact of an educational intervention on undergraduate students’ knowledge, acceptability, and willingness to pay for dapivirine vaginal ring in Nigeria's first indigenous university: a single-arm, non-randomized study [PDF]

Discover Social Science and Health
Background This study aimed to assess the impact of an educational intervention on knowledge, acceptability, and willingness to pay (WTP) for dapivirine vaginal ring (DPV-VR) by undergraduate female students at the University of Nigeria (UNN).
Abdulmuminu Isah, Gabriel Ezenri, Ogechi Obi, Nnamdi A. Okibe, Hadiza Usman Ma’aji, Ezinwanne J. Ugochukwu, Cynthia C. Eze, Chisom M. Amoke, Augustus Ezeodimegwu, Charles C. Idabor, Mustapha Muhammed Abubakar, Francis Iloabuchi, Ikenna John Ugwu, Chukwuebuka M. Asogwa, Chinwe V. Ukwe, Blessing Onyinye Ukoha-kalu   +15 more
doaj   +3 more sources

Leveraging international stakeholders’ experiences with oral PrEP costs to accelerate implementation of the monthly dapivirine vaginal ring: A qualitative study [PDF]

Health Research Policy and Systems
Background Costing and financing systematic implementation are recognized barriers to human immunodeficiency virus (HIV) prevention. In the absence of empiric implementation and economic data, perspectives from international stakeholders involved in ...
Craig J. Heck, Katharine Kripke, Anita Dam, Sergio Torres-Rueda, Fiammetta Bozzani, Chris Obermeyer, Kibret Yohannes, Justine Deacon, Kathrine Meyers, Daniela Quigee, Sarah Wiant, Steven Forsythe, Christine Malati, Martha Larson, Magdalena E. Sobieszczyk, Delivette Castor   +15 more
doaj   +2 more sources

Associations between intravaginal practices and incidence of sexually transmitted infections and bacterial vaginosis among women enrolled in the dapivirine vaginal ring trial (The Ring Study) in southwestern Uganda: a retrospective secondary analysis [PDF]

BMJ Open
Objectives We assessed associations between intravaginal practices (IVPs) and the incidence of sexually transmitted infections (STIs) and bacterial vaginosis (BV) among women using the dapivirine vaginal ring (DVR) or placebo vaginal ring in southwestern
Andrew Abaasa, Eugene Ruzagira, Sylvia Kusemererwa, Anita Kabarambi, Martin Onyango   +4 more
doaj   +2 more sources

Values and preferences of female sex workers in Zimbabwe for long-acting injectable pre-exposure prophylaxis and the dapivirine vaginal ring: results of a mixed-methods research study [PDF]

BMJ Global Health
Introduction Female sex workers (FSWs) in sub-Saharan Africa are at high risk of HIV acquisition. Here we explore the values and preferences of Zimbabwean FSW for long-acting pre-exposure prophylaxis (PrEP).Methods We employed mixed methods; focus group ...
Frances M Cowan, Sungai T Chabata, Rachel Baggaley, Michelle Rodolph, Marc d'Elbée, Fortunate Machingura, Tatenda Kujeke, Jasper Maguma   +7 more
doaj   +2 more sources

Evaluating the potential impact and cost-effectiveness of dapivirine vaginal ring pre-exposure prophylaxis for HIV prevention. [PDF]

PLoS ONE, 2019
BackgroundExpanded HIV prevention options are needed to increase uptake of HIV prevention among women, especially in generalized epidemics. As the dapivirine vaginal ring moves forward through regulatory review and open-label extension studies, the ...
Meghan Reidy, Elizabeth Gardiner, Carel Pretorius, Robert Glaubius, Kristine Torjesen, Katharine Kripke   +5 more
doaj   +2 more sources