Results 21 to 30 of about 1,789 (171)

Acceptability of the Dapivirine Vaginal Ring in Postmenopausal US Women. [PDF]

AIDS Patient Care STDS, 2022
For women in the United States who remain sexually active beyond child-bearing years, susceptibility to HIV infection remains, yet condom use is low. We assessed acceptability of the dapivirine vaginal ring (ring) among 96 postmenopausal US women enrolled in a placebo-controlled multisite phase II trial of the ring, using questionnaires and in-depth ...
Shapley-Quinn MK, Laborde N, Luecke E, Hoesley C, Salata RA, Johnson S, Nel A, Soto-Torres L, Chen BA, van der Straten A.   +9 more
europepmc   +3 more sources

Efficacy of the Dapivirine Vaginal Ring Accounting for Imperfect Adherence. [PDF]

AIDS Behav
Product adherence is critical to obtaining objective estimates of efficacy of pre-exposure prophylactic interventions against HIV-1 infection. With imperfect adherence, intention-to-treat analyses assess the collective effects of complete, sub-optimal and non-adherence, providing a biased and attenuated estimate of the average causal effect of an ...
Husnik MJ, Heffron R, Hughes JP, Richardson B, van der Straten A, Palanee-Phillips T, Soto-Torres L, Singh D, Mirembe BG, Livant E, Gaffoor Z, Mansoor LE, Siva SS, Dadabhai S, Kiweewa FM, Baeten JM, MTN-020/ASPIRE Study Team.   +16 more
europepmc   +3 more sources

The Influence of Perceived Dapivirine Vaginal Ring Effectiveness on Social Disclosure and Ring Adherence. [PDF]

AIDS Behav, 2021
We analyzed data from 1428 users of the dapivirine vaginal ring, who participated in the MTN-020/ASPIRE phase III trial and subsequent open-label extension MTN-025/HOPE trial, to examine relationships between perceived ring protection, social disclosures, and self-reported ring adherence. In HOPE, 77% perceived the ring to be highly effective, and this
Stoner MCD, Brown ER, Palanee-Phillips T, Mansoor LE, Tembo T, Nair G, Akello C, Seyama L, Jeenarain N, Naidoo L, Mgodi N, Hunidzarira P, Chitukuta M, van der Straten A, MTN-020 ASPIRE and M-025 HOPE study teams.   +14 more
europepmc   +3 more sources

The dapivirine vaginal ring from the perspective of married men in Uganda [PDF]

African Journal of AIDS Research, 2021
Background: Men play a key role in influencing uptake of women's health products, such as female condoms and vaginal microbicides used for family planning and HIV prevention.Method: We explored men's perceptions of the dapivirine vaginal ring (DVR), a vaginal microbicide, in Kalungu District, rural south-western Uganda.
Anita Kabarambi, Sylvia Kusemererwa, Emily Krogstad, Philippe Mayaud, Janet Seeley, Joseph Mugisha, Mitzy Gafos   +6 more
openaire   +2 more sources

Use of the dapivirine vaginal ring and effect on cervical cytology abnormalities. [PDF]

AIDS, 2020
Objective: We aimed to determine if the dapivirine vaginal ring and the ring device alone (flexible silicone matrix polymer) was associated with the development of cervical cytology abnormalities. Design: Secondary analysis comparing cervical cytology results between two randomized ...
Reddy K, Kelly C, Brown ER, Jeenarain N, Naidoo L, Siva S, Bekker LG, Nair G, Makanani B, Chinula L, Mgodi N, Chirenje Z, Kiweewa FM, Marrazzo J, Bunge K, Soto-Torres L, Piper J, Baeten JM, Palanee-Phillips T, MTN-020/ASPIRE and MTN-003/VOICE Study Teams.   +19 more
europepmc   +6 more sources

Strategies implemented for accurate dispensing of an investigational new drug in a multi-site HIV prevention clinical trial

Contemporary Clinical Trials Communications, 2021
Safe practices for dispensing investigational product (IP) during clinical trials are not standardized and information in this regard is often limited.
Cindy Jacobson, Jayajothi Moodley, Aruna Bhoola, Rebecca Sakwa, Jeeva Moodley, Jasmin Sukdao, Nivriti Hurbans, Bhavna Maharaj, Anushka Naidoo, Melanie Maclachlan, Gift Chareka, Kudzai Hlahla, Mary Chadza   +12 more
doaj   +1 more source

In vitro drug release, mechanical performance and stability testing of a custom silicone elastomer vaginal ring releasing dapivirine and levonorgestrel

International Journal of Pharmaceutics: X, 2022
We have previously reported a multipurpose silicone elastomer vaginal ring providing sustained release of dapivirine (an antiretroviral) and levonorgestrel (a progestin) for HIV prevention and hormonal contraception.
Diarmaid J. Murphy, Yahya H. Dallal Bashi, Clare F. McCoy, Peter Boyd, Leeanne Brown, François Martin, Nicole McMullen, Kyle Kleinbeck, Bindi Dangi, Patrick Spence, Bashir Hansraj, Bríd Devlin, R. Karl Malcolm   +12 more
doaj   +1 more source

Dapivirine-releasing vaginal rings produced by plastic freeforming additive manufacturing [PDF]

International Journal of Pharmaceutics, 2019
Here we report the first use of an additive manufacturing (AM) technique based on high pressure material jetting of molten thermoplastic for the fabrication of dapivirine (DPV) loaded vaginal rings (VRs). The VRs are compared to those produced conventionally using injection molding (IM).
Nicole R. Welsh, R. Karl Malcolm, Brid Devlin, Peter Boyd   +3 more
openaire   +4 more sources

Multipurpose vaginal rings for HIV prevention and non-hormonal contraception

British Journal of Pharmacy, 2022
Vaginal rings releasing antiretrovirals - either alone or in combination with contraceptive progestins - are being developed for contraception and prevention of human immunodeficiency virus (HIV) transmission via vagina.
Xin Shen, Peter Boyd, Yahya Dallal Bashi, Clare McCoy , Karl Malcolm   +4 more
doaj   +1 more source

Assessment of risk compensation following use of the dapivirine vaginal ring in southwestern Uganda. [PDF]

Sex Transm Infect, 2022
ObjectivesParticipation in HIV prevention trials could trigger risk compensation among participants. We evaluated potential risk compensation following use of a vaginal ring microbicide by women in a phase III trial in southwestern Uganda.MethodsWe used markers of sexual risk behaviour documented on standardised questionnaires, tested for STIs at ...
Kusemererwa S, Abaasa A, Kabarambi A, Onyango M, Mugisha JO.   +4 more
europepmc   +4 more sources