Results 11 to 20 of about 1,789 (171)

Packing polymorphism of dapivirine and its impact on the performance of a dapivirine-releasing silicone elastomer vaginal ring [PDF]

Journal of Pharmaceutical Sciences, 2017
PRISMA Checklist (PDF 545Â ...
McCoy, Clare F., Murphy, Diarmaid J., Boyd, Peter, Derrick, Tiffany, Spence, Patrick, Devlin, Brid, Malcolm, Robert   +6 more
core   +10 more sources

Correlates of Adherence to the Dapivirine Vaginal Ring for HIV-1 Prevention. [PDF]

AIDS Behav, 2021
Understanding characteristics associated with adherence to pre-exposure prophylaxis (PrEP) methods for HIV-1 prevention may assist with optimizing implementation efforts. The dapivirine vaginal ring is a novel topical PrEP delivery method. Using data from a randomized, double-blind, placebo-controlled, phase III trial of the dapivirine vaginal ring ...
Husnik MJ, Brown ER, Dadabhai SS, Gaffoor Z, Jeenarain N, Kiweewa FM, Livant E, Mansoor LE, Mirembe BG, Palanee-Phillips T, Singh D, Siva S, Soto-Torres L, van der Straten A, Baeten JM, M. T. N.-020/ASPIRE Study Team.   +15 more
europepmc   +5 more sources

Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women [PDF]

New England Journal of Medicine, 2016
The incidence of human immunodeficiency virus (HIV) infection remains high among women in sub-Saharan Africa. We evaluated the safety and efficacy of extended use of a vaginal ring containing dapivirine for the prevention of HIV infection in 1959 healthy, sexually active women, 18 to 45 years of age, from seven communities in South Africa and Uganda.In
Annalene, Nel, Neliëtte, van Niekerk, Saidi, Kapiga, Linda-Gail, Bekker, Cynthia, Gama, Katherine, Gill, Anatoli, Kamali, Philip, Kotze, Cheryl, Louw, Zonke, Mabude, Nokuthula, Miti, Sylvia, Kusemererwa, Hugo, Tempelman, Hannelie, Carstens, Brid, Devlin, Michelle, Isaacs, Mariëtte, Malherbe, Winel, Mans, Jeremy, Nuttall, Marisa, Russell, Smangaliso, Ntshele, Marlie, Smit, Leonard, Solai, Patrick, Spence, John, Steytler, Kathleen, Windle, Maarten, Borremans, Sophie, Resseler, Jens, Van Roey, Wim, Parys, Tony, Vangeneugden, Ben, Van Baelen, Zeda, Rosenberg   +32 more
exaly   +5 more sources

Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel

International Journal of Pharmaceutics: X, 2021
A dapivirine-releasing silicone elastomer vaginal ring for reducing women's risk of HIV acquisition has recently been approved. A next-generation multipurpose vaginal ring releasing dapivirine and levonorgestrel is currently in development, offering ...
Yahya H. Dallal Bashi, Diarmaid J. Murphy, Clare F. McCoy, Peter Boyd, Leeanne Brown, Matthew Kihara, François Martin, Nicole McMullen, Kyle Kleinbeck, Bindi Dangi, Patrick Spence, Bashir Hansraj, Brid Devlin, R. Karl Malcolm   +13 more
doaj   +5 more sources

Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women [PDF]

Obstetrical & Gynecological Survey, 2016
Antiretroviral medications that are used as prophylaxis can prevent acquisition of human immunodeficiency virus type 1 (HIV-1) infection. However, in clinical trials among African women, the incidence of HIV-1 infection was not reduced, probably because of low adherence. Longer-acting methods of drug delivery, such as vaginal rings, may simplify use of
Baeten, Jared M, Palanee-Phillips, Thesla, Brown, Elizabeth R, Schwartz, Katie, Soto-Torres, Lydia E, Govender, Vaneshree, Mgodi, Nyaradzo M, Matovu Kiweewa, Flavia, Nair, Gonasagrie, Mhlanga, Felix, Siva, Samantha, Bekker, Linda-Gail, Jeenarain, Nitesha, Gaffoor, Zakir, Martinson, Francis, Makanani, Bonus, Pather, Arendevi, Naidoo, Logashvari, Husnik, Marla, Richardson, Barbra A, Parikh, Urvi M, Mellors, John W, Marzinke, Mark A, Hendrix, Craig W, van der Straten, Ariane, Ramjee, Gita, Chirenje, Zvavahera M, Nakabiito, Clemensia, Taha, Taha E, Jones, Judith, Mayo, Ashley, Scheckter, Rachel, Berthiaume, Jennifer, Livant, Edward, Jacobson, Cindy, Ndase, Patrick, White, Rhonda, Patterson, Karen, Germuga, Donna, Galaska, Beth, Bunge, Katherine, Singh, Devika, Szydlo, Daniel W, Montgomery, Elizabeth T, Mensch, Barbara S, Torjesen, Kristine, Grossman, Cynthia I, Chakhtoura, Nahida, Nel, Annalene, Rosenberg, Zeda, McGowan, Ian, Hillier, Sharon   +51 more
openaire   +7 more sources

Matrix and reservoir-type multipurpose vaginal rings for controlled release of dapivirine and levonorgestrel [PDF]

International Journal of Pharmaceutics, 2016
A matrix-type silicone elastomer vaginal ring providing 28-day continuous release of dapivirine (DPV) - a lead candidate human immunodeficiency virus type 1 (HIV-1) microbicide compound - has recently demonstrated moderate levels of protection in two ...
Blanda, Wendy, Boyd, Peter, Brimer, Andrew, Devlin, Brid, Fetherston, Susan M, Holt, Jonathon, Kumar, Sandeep, Major, Ian, Malcolm, R Karl, McCoy, Clare F, Murphy, Diarmaid J   +10 more
core   +7 more sources

Pharmacokinetics of Dapivirine Transfer into Blood Plasma, Breast Milk, and Cervicovaginal Fluid of Lactating Women Using the Dapivirine Vaginal Ring [PDF]

Antimicrobial Agents and Chemotherapy, 2019
Breastfeeding (BF) women are an important population for biomedical HIV prevention strategies, but they are rarely included in trials. The 25-mg dapivirine vaginal ring (VR) reduced women’s risk of sexually transmitted HIV infection in two phase 3 trials conducted in Africa.
Lisa M. Noguchi, Craig Hoesley, Cliff Kelly, Rachel Scheckter, Katherine Bunge, Annalene Nel, Mark A. Marzinke, Craig W. Hendrix, Charlene S. Dezzutti, Sharon L. Hillier, Debra L. Bogen, Jeanna M. Piper, Richard H. Beigi   +12 more
openaire   +6 more sources

Pre-clinical development of a combination microbicide vaginal ring containing dapivirine and darunavir [PDF]

Journal of Antimicrobial Chemotherapy, 2014
Combination microbicide vaginal rings may be more effective than single microbicide rings at reducing/preventing sexual transmission of HIV. Here, we report the pre-clinical development and macaque pharmacokinetics of matrix-type silicone elastomer vaginal rings containing dapivirine and darunavir.Macaque rings containing 25 mg dapivirine, 100 mg ...
Murphy, Diarmaid J., Desjardins, Delphine, Dereuddre-Bosquet, Nathalie, Brochard, Patricia, Perrot, Ludivine, Pruvost, Alain, Le Grand, Roger, Lagatie, Ole, Vanhooren, Leen, Feyaerts, Maxim, van Roey, Jens, Malcolm, R. Karl   +11 more
openaire   +6 more sources

PrEP choice in the real world: Results of a prospective cohort study describing uptake and use patterns of oral PrEP and the dapivirine vaginal ring among women in sub‐Saharan Africa [PDF]

Journal of the International AIDS Society
Introduction HIV incidence remains high among women in Africa, especially adolescent girls and young women (AGYW), despite existing oral pre‐exposure prophylaxis (PrEP) programmes.
Virginia A. Fonner, Elizabeth Irungu, Mark Conlon, Carolyne A. Akello, Emily Gwavava, Kevin K'Orimba, Nicolette P. Naidoo, Patriciah Jeckonia, Imelda Mahaka, Saiqa Mullick, Mamatli Chabela, Roisin Drysdale, Jacqueline Kabongo, Millicent Kiruki, Ivan Segawa, Munyaradzi Dobbie, Nthuseng Marake, Peter Mudiope, Hasina Subedar, Rose Wafula, Andrew Kazibwe, Jason Reed, Katharine Kripke, Douglas Taylor, Mu‐Tien Lee, Glory Chidumwa, Adatia Chivafa, Ramatsoai Soothoane, Margaret Eichleay, Ashley Mayo, Courtney McGuire, Tara McClure, Tatenda Yemeke, Kristine Torjesen, the CATALYST study team   +34 more
doaj   +2 more sources

Density Mediated Drug Release From Dapivirine Vaginal Rings Produced by Additive Manufacturing [PDF]

, 2018
Background: Droplet deposition modelling (DDM) is a form of 3D printing that fuses droplets of molten polymer to create each layer, providing exquisite levels of control over an object‘s design and morphology.
Boyd, Peter, Devlin, Brid, Malcolm, Robert, McCoy, Clare F., Murphy, Diarmaid, Welsh, Nicole   +5 more
core   +3 more sources