Results 91 to 100 of about 27,037 (216)

Plasma Protein Binding Structure–Activity Relationships Related to the N-Terminus of Daptomycin

, 2017
Daptomycin is a lipopeptide antibiotic that is highly bound to plasma proteins. To date, the plasma components and structure–activity relationships responsible for the plasma protein binding profile of daptomycin remain uncharacterized.
Yan Zhu, Elena K. Schneider, Keith K. Khoo, Cooper, Matthew A, Johnson Mak, Mak, Johnson, Matthew A. Cooper, Schneider, Elena K, Huang, Johnny X, Tony Velkov, Meiling Han, Velkov, Tony, Sue Nang, Jian Li, Johnny X. Huang, Han, Meiling, Nang, Sue, Carbone, Vincenzo, Vincenzo Carbone, Khoo, Keith K, Li, Jian, Zhu, Yan   +21 more
core   +1 more source

A daptomycin biotechnológiai úton történő előállítása

, 2013
A daptomycin, egy lipopeptid antibiotikum bemutatása és fermentáció általi előállításának ismertetése. Szó esik a dolgozatban a gyártáshoz használt Streptomyces roseosporusról és rövid ismertetése is megtörténik.
Kerekes, Fanni
core  

Multi-strain Tn-Seq reveals common daptomycin resistance determinants in Staphylococcus aureus

PLoS Pathogens, 2019
Antibiotic-resistant Staphylococcus aureus remains a leading cause of antibiotic resistance-associated mortality in the United States. Given the reality of multi-drug resistant infections, it is imperative that we establish and maintain a pipeline of new
Kathryn A. Coe, Wonsik Lee, Madeleine C Stone, Gloria Komazin-Meredith, Timothy C. Meredith, Y. Grad, S. Walker   +6 more
semanticscholar   +1 more source

Daptomycin–β-Lactam Combinations in a Rabbit Model of Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus Endocarditis [PDF]

, 2016
Beta-lactams enhance the in vitro activity of daptomycin against methicillin-resistant strains of Staphylococcus aureus Experiments were performed in a rabbit model of aortic valve endocarditis caused by methicillin-resistant daptomycin-nonsusceptible S.
Hamilton, Stephanie M, Chambers, Henry F, Choo, Eun Ju, Moise, Pamela, Basuino, Li   +4 more
core   +1 more source

Daptomycin-Nonsusceptible, Vancomycin-Intermediate, Methicillin-Resistant Staphylococcus aureus Endocarditis

Canadian Journal of Infectious Diseases and Medical Microbiology, 2012
Due to the emergence of Staphylococcus aureus with reduced vancomycin susceptibility, newer antibiotics, including daptomycin, have been used to treat methicillin-resistant S aureus infections. Daptomycin is a cyclic lipopeptide that is approved to treat
Ryan Yu, Suzanne E Dale, Deborah Yamamura, Vida Stankus, Christine Lee   +4 more
doaj   +1 more source

Chemoenzymatic synthesis of daptomycin analogs active against daptomycin-resistant strains

Applied Microbiology and Biotechnology, 2020
Daptomycin is a last resort antibiotic for the treatment of infections caused by many Gram-positive bacterial strains, including vancomycin-resistant Enterococcus (VRE) and methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA ...
Erin M. Scull, Chandrasekhar Bandari, Bryce P. Johnson, Eric D Gardner, M. Tonelli, J. You, R. Cichewicz, Shanteri Singh   +7 more
semanticscholar   +1 more source

Development of pilot plant fermentation in the pharmaceutical industry – active pharmaceutical ingredient: Daptomycin

, 2016
A daptomycin nevű antibiotikum termeltetésének kísérleti üzemi léptékű fejlesztése, a technológia optimalizálása. A dolgozat célkitűzése volt: a technológia reprezentatív módon történő bemutatása, a daptomycin kihozatalának növelése, a hatóanyag mellett ...
Anga, Csilla
core  

Daptomycin versus linezolid for the treatment of vancomycin-resistant enterococcal bacteraemia: implications of daptomycin dose

, 2017
Treatment options for vancomycin-resistant enterococci (VRE) bloodstream infection are limited. Studies comparing daptomycin or linezolid in treating VRE bloodstream infection have conflicting results and suggest daptomycin underdosing.
Chuang, Y-C.;Lin, H-Y.;Chen, P-Y.;Lin, C-Y.;Wang, J-T.;Chang, S-C., 張上淳;王振泰;林哲儀;莊祐中;林綺英   +1 more
core   +1 more source

Defective pgsA contributes to increased membrane fluidity and cell wall thickening in Staphylococcus aureus with high-level daptomycin resistance

mSphere
Daptomycin is a membrane-targeting last-resort antimicrobial therapeutic for the treatment of infections caused by methicillin- and/or vancomycin-resistant Staphylococcus aureus. In the rare event of failed daptomycin therapy, the source of resistance is
Christian D. Freeman, Tayte Hansen, Ramona Urbauer, Brian J. Wilkinson, Vineet K. Singh, Kelly M. Hines   +5 more
doaj   +1 more source

Daptomycin for Pediatric Gram-Positive Acute Hematogenous Osteomyelitis

The Pediatric Infectious Disease Journal, 2020
Supplemental Digital Content is available in the text. Background: We prospectively evaluated efficacy and safety of daptomycin versus active comparator in children with acute hematogenous osteomyelitis (AHO).
J. Bradley, A. Arrieta, V. Digtyar, M. Popejoy, Anjana Grandhi, P. Bokesch, E. Hershberger, M. Dorr, Christopher M. Tan, Y. Murata, Dominik J. Wolf, M. Bensaci   +11 more
semanticscholar   +1 more source