Results 81 to 90 of about 27,037 (216)

Hypothesis: daptomycin permeabilizes membranes by forming self‑assembled nanotubes

, 2020
Daptomycin is the only lipopeptide antibiotic that is widely used in clinical practice. It was discovered by Eli Lilly and then studied and commercialized by Cubist Pharmaceuticals in 2003.
A. Zhivich
core   +1 more source

Physicochemical Characterization of Daptomycin Interaction with Negatively Charged Lipid Membranes

Langmuir, 2020
Daptomycin is known as an effective antibiotic lipopeptide which shows activity against the number of Gram-positive pathogens. Its primary target is the bacterial cell membrane.
Joanna Juhaniewicz-Dębińska, D. Dziubak, S. Sęk   +2 more
semanticscholar   +1 more source

Antimicrobial Stewardship Intervention and Feedback to Infectious Disease Specialists: A Case Study in High-Dose Daptomycin

Antibiotics, 2015
Infectious Diseases specialists have used high-dose daptomycin (≥6 mg/kg/day) in select patients with difficult to treat methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus (VRE) infections to optimize outcomes ...
Jennifer L. Ross, Shannon Rankin, Patricia Marshik, Renée-Claude Mercier, Meghan Brett, Carla J. Walraven   +5 more
doaj   +1 more source

Methylation of Daptomycin Leading to the Discovery of Kynomycin, a Cyclic Lipodepsipeptide Active Against Resistant Pathogens.

Journal of Medicinal Chemistry, 2020
Increased usage of daptomycin to treat infections caused by Gram-positive bacterial pathogens has resulted in emergence of resistant mutants. In a search for more effective daptomycin analogues through medicinal chemistry studies, we found that ...
H. Chow, K. Po, P. Gao, Pilar Blasco, Xiukun Wang, Congran Li, L. Ye, K. Jin, Kaichao Chen, E. Chan, Xuefu You, Richard Yi Tsun Kao, Sheng Chen, Xuechen Li   +13 more
semanticscholar   +1 more source

Bactericidal activity of daptomycin versus vancomycin in the presence of human albumin against vancomycin-susceptible but tolerant methicillin-resistant Staphylococcus aureus (MRSA) with daptomycin minimum inhibitory concentrations of 1–2μg/mL

, 2010
This study explored the influence of vancomycin tolerance and protein binding on the bactericidal activity of vancomycin versus daptomycin (protein binding 36.9% vs.
Giménez, María José, Alou Cervera, Luis, Torrico, Martha, Prieto Prieto, José, Aguilar, Lorenzo, González Hidalgo, Natalia, Cafini, Fabio, Sevillano Fernández, David, Cleeland, R.   +8 more
core   +1 more source

In-Host Evolution of Daptomycin Resistance and Heteroresistance in Methicillin-Resistant Staphylococcus aureus Strains From Three Endocarditis Patients.

Journal of Infectious Diseases, 2020
BACKGROUND Daptomycin is considered an important alternative for the treatment of methicillin-resistant Staphylococcus aureus (MRSA). However, treatment failures associated with daptomycin nonsusceptibility isolates have been reported in recent years ...
S. Ji, Shengnan Jiang, X. Wei, Lu Sun, Hai-ping Wang, Feng Zhao, Yan Chen, Yunsong Yu   +7 more
semanticscholar   +1 more source

Addition of daptomycin to levofloxacin increased the efficacy of levofloxacin monotherapy against a methicillin-susceptible Staphylococcus aureus strain in experimental meningitis and prevented development of resistance in vitro.

, 2022
Introduction. Daptomycin and levofloxacin were tested as monotherapies and in combination against the antibiotic-susceptible S. aureus strain MSSA 1112 in a rabbit meningitis model and the effect of the combination on induction of resistance was ...
Collaud, Alexandra, Cottagnoud, Marianne, Cottagnoud, Philippe, Perreten, Vincent, Ashkbus, Reza, Sprenker, Frederike   +5 more
core   +1 more source

In vitro persistence of clinical methicillin-resistant Staphylococcus aureus isolates from bone and joint infections after exposure to daptomycin, telavancin, and vancomycin

Microbiology Spectrum
Bacterial persistence is linked to chronic infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Understanding the persister profiles of daptomycin, telavancin, and vancomycin is crucial because MRSA bone and joint infections (BJIs ...
Aliaa Fouad, Joseph L. Kuti, Christian M. Gill   +2 more
doaj   +1 more source

MprF-mediated daptomycin resistance.

International Journal of Medical Microbiology, 2019
Daptomycin has become an important antibiotic for the treatment of serious Methicillin-Resistant Staphylococcus aureus (MRSA) infections. Unlike other approved antibiotics, its mode of action is still under active investigation, as well as the molecular ...
Christoph M. Ernst, A. Peschel
semanticscholar   +1 more source

Efficacy and safety of daptomycin versus linezolid treatment in patients with vancomycin-resistant enterococcal bacteraemia: an updated systematic review and meta-analysis.

Journal of Global Antimicrobial Resistance, 2020
OBJECTIVES We conducted a systematic review and meta-analysis to re-assess the efficacy and safety of daptomycin compared with linezolid treatment for vancomycin-resistant enterococcal (VRE) bacteraemia and to explore whether high-dose daptomycin is ...
Changcheng Shi, Weizhong Jin, Yaping Xie, Dongmei Zhou, Shuang Xu, Qingyu Li, Nengming Lin   +6 more
semanticscholar   +1 more source