Results 61 to 70 of about 27,037 (216)

Daptomycin: Local Application in Implant-Associated Infection and Complicated Osteomyelitis

open access: yesThe Scientific World Journal, 2012
Background. The rise of highly resistant bacteria creates a persistent urge to develop new antimicrobial agents. This paper investigates the application of the lipopeptide antibiotic daptomycin in infections involving the human bone. Methods. Compressive
Steffen B. Rosslenbroich   +6 more
doaj   +1 more source

Treatment of bacteremia by vancomycin-resistant Enterococcus with daptomycin versus linezolid: a systematic review and meta-analyses

open access: yesIatreia, 2017
Introduction: Second-line drugs such as linezolid and daptomycin are used for treatment of vancomycin-resistant Enterococcus (VRE) infections. Objective: A systematic review to evaluate treatment of VRE bacteremia with linezolid versus daptomycin ...
Caicedo-Ochoa, Edgar Yaset   +4 more
doaj   +1 more source

Pharmacokinetics and Safety of Multiple Intravenous Doses of Daptomycin in a Taiwanese Adult Population

open access: yes, 2011
Background: The pharmacokinetics (PK) and safety of daptomycin have not yet been studied in an adult Taiwanese population. Methods: A total of 13 healthy adult Taiwanese subjects (7 males and 6 females) were enrolled to receive a 5-day course of multiple
梁修豪;盛望徽;黃昱璁;林慧玲;張上淳   +1 more
core   +1 more source

Daptomycin to bone and joint infections and prosthesis joint infections: a systematic review

open access: yesBrazilian Journal of Infectious Diseases, 2019
Backgroud: Daptomycin has been used in bone and joint infections (BJI) and prosthesis joint infections (PJI) considering spectrum of activity and biofilm penetration.
João Paulo Telles   +2 more
doaj   +1 more source

Elasnin Effectively Eradicates Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Biofilms

open access: yesMicrobiology Spectrum, 2022
Elasnin is a recently reported antibiofilm agent that is effective against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).
Jordy Evan Sulaiman   +3 more
doaj   +1 more source

Antibiotic Combinations Preventing Bacterial Resistance: Studies on an in vitro Model with Staphylococcus aureus Exposed to Linezolid–Daptomycin

open access: yesАнтибиотики и Химиотерапия, 2020
To predict the anti-mutant effects of antibiotic combinations against Staphylococcus aureus, the mutant prevention concentrations (MPCs) of linezolid and daptomycin were determined at a linezolid-to-daptomycin concentration ratio that corresponds to the ...
K. N. Alieva   +3 more
doaj   +3 more sources

Population Pharmacokinetic/Pharmacodynamic Modelling of Daptomycin for Schedule Optimization in Patients with Renal Impairment

open access: yesPharmaceutics, 2022
The aims of this study are (i) to develop a population pharmacokinetic/pharmacodynamic model of daptomycin in patients with normal and impaired renal function, and (ii) to establish the optimal dose recommendation of daptomycin in clinical practice ...
Teresa García-Martínez   +5 more
doaj   +1 more source

Safety and efficacy of daptomycin for the treatment of hospitalized adult patients in Taiwan with severe staphylococcal infections

open access: yes, 2014
Background and Purpose: The safety and efficacy of treating serious infections caused by Staphylococcus aureus with daptomycin in a Taiwanese population were studied.
張上淳   +1 more
core   +1 more source

Daptomycin is more efficacious than vancomycin against a methicillin-susceptible Staphylococcus aureus in experimental meningitis [PDF]

open access: yes, 2006
OBJECTIVES: To test the efficacy of daptomycin, a cyclic lipopeptide antibiotic, against a methicillin-susceptible Staphylococcus aureus strain in experimental rabbit meningitis and to determine its penetration into non-inflamed and inflamed meninges ...
Stucki, Armin   +4 more
core   +1 more source

Investigating Daptomycin–Membrane Interactions Using Native MS and Fast Photochemical Oxidation of Peptides in Nanodiscs

open access: yes, 2023
Daptomycin is a cyclic lipopeptide antibiotic that targets the lipid membrane of Gram-positive bacteria. Membrane fluidity and charge can affect daptomycin activity, but its mechanisms are poorly understood because it is challenging to study daptomycin ...
Michael, Marty   +9 more
core   +1 more source

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