Results 61 to 70 of about 29,458 (191)

Host Transcriptomics and Culture‐Independent Testing for the Management of Febrile Neutropenia: Data From an Observational Study Conducted in a Bone Marrow Transplant Unit

European Journal of Haematology, Volume 116, Issue 5, Page 625-634, May 2026.
ABSTRACT Background Managing febrile neutropenia is challenging due to the limited sensitivity of blood culture (BC) and the lack of tools differentiating infectious from non‐infectious fever. T2 magnetic resonance (T2MR) is a culture‐independent system detecting bacteria (T2Bacteria) and yeasts (T2Candida); SeptiCyte RAPID is a host response assay ...
Anna Maria Peri, Andrea S. Henden, Ricky Nelles, Mark D. Chatfield, Patrick N. A. Harris, Glen Kennedy, David L. Paterson   +6 more
wiley   +1 more source

Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of Staphylococcus aureus.

PLoS ONE, 2012
BackgroundDaptomycin remains one of our last-line anti-staphylococcal agents. This study aims to characterize the genetic evolution to daptomycin resistance in S.
Anton Y Peleg, Spiros Miyakis, Doyle V Ward, Ashlee M Earl, Aileen Rubio, David R Cameron, Satish Pillai, Robert C Moellering, George M Eliopoulos   +8 more
doaj   +1 more source

Daptomycin treatment impacts resistance in off-target populations of vancomycin-resistant Enterococcus faecium.

PLoS Biology, 2020
The antimicrobial resistance crisis has persisted despite broad attempts at intervention. It has been proposed that an important driver of resistance is selection imposed on bacterial populations that are not the intended target of antimicrobial therapy.
Clare L Kinnear, Elsa Hansen, Valerie J Morley, Kevin C Tracy, Meghan Forstchen, Andrew F Read, Robert J Woods   +6 more
doaj   +1 more source

Scope and Predictive Genetic/Phenotypic Signatures of Bicarbonate (NaHCO3) Responsiveness and β-Lactam Sensitization in Methicillin-Resistant Staphylococcus aureus. [PDF]

, 2020
Addition of sodium bicarbonate (NaHCO3) to standard antimicrobial susceptibility testing medium reveals certain methicillin-resistant Staphylococcus aureus (MRSA) strains to be highly susceptible to β-lactams.
Bayer, Arnold S, Chambers, Henry F, Chen, Liang, Ersoy, Selvi C, Fowler, Vance G, Kreiswirth, Barry, Li, Liang, Mediavilla, Jose, Milan, Vanessa T, Otmishi, Mariam, Pak, Youngju, Proctor, Richard A, Xiong, Yan Q   +12 more
core   +1 more source

Allium‐Derived Compounds Against Multidrug‐Resistant Bacteria: Antibacterial Activity and Synergistic Effects

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
This study evaluates four compounds derived from the genus Allium against 330 multidrug‐resistant bacteria. Propyl‐propane‐thiosulfonate (PTSO) exhibits the highest activity, particularly against Gram‐positive strains, while Gram‐negative bacteria are less affected.
Antonio Sorlózano‐Puerto, Yariel Figueroa‐Vega, Pablo Martín‐Valenzuela, José Manuel de la Torre‐Ramírez, Alberto Baños, José Gutiérrez‐Fernández   +5 more
wiley   +1 more source

Differential Activity of the Combination of Vancomycin and Amikacin on Planktonic vs. Biofilm-Growing Staphylococcus aureus Bacteria in a Hollow Fiber Infection Model [PDF]

, 2018
Combining currently available antibiotics to optimize their use is a promising strategy to reduce treatment failures against biofilm-associated infections. Nevertheless, most assays of such combinations have been performed in vitro on planktonic bacteria
Adamis, Aeschlimann, Backo, Brown, Butterfield, Cadwell, Cargill, Cokça, Conlon, Davies, Deresinski, Donlan, Doroshenko, Drusano, Ekdahl, Ferro, Frimodt-Møller, Gumbo, Gálvez, Hanrahan, Hogan, Ivanova, Jung, Kato, Knudsen, Lamp, LaPlante, LaPlante, Lebeaux, Lebeaux, Lenhard, Lewis, Liu, Mandell, Matzke, McConoughey, Moore, Nicasio, Nielsen, Patel, Post, Rodloff, Rybak, Singh, Singh, Song, Srinivasan, Toutain, Toutain, Toutain, Waineo, Watanakunakorn, Wu, Yanagisawa, Yuan, Zelenitsky, Álvarez   +56 more
core   +3 more sources

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, Volume 13, Issue 20, 9 April 2026.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source

Antimicrobial use in European acute care hospitals: results from the second point prevalence survey (PPS) of healthcare-associated infections and antimicrobial use, 2016 to 2017 [PDF]

, 2018
Antimicrobial agents used to treat infections are life-saving. Overuse may result in more frequent adverse effects and emergence of multidrug-resistant microorganisms.
Aghdassi, S., Alberg, T., Arendt, V., Arvaniti, K., Asensio, A., Berg, T. C., Berger-Carbonne, A., Borg, M. A., Bosnjak, Z., Budimir, A., Burns, K., Cairns, S., Cantero, M., Daniau, C., Debacker, M., Deptula, A., Dimina, E., Dobreva, E., Dragovac, G., Florentin, D., Gastmeier, P., Gibbons, C., Gudlaugsson, O., Hadjihannas, L., Hajdu, A., Hansen, S., Harrison, W., Hopkins, S., Hopmans, T., Hristova, R., Ivanov, I. N., Jindrak, V., Johnson, A., Karki, T., Kinross, P., Kontopidou, F., Korosec, A., Latour, K., Litvova, S., Lyytikainen, O., Markovic-Denic, L., Martin, P., McConaghy, M., Mitt, P., Monnet, D. L., Moro, M. L., Nedyalkov, M., Neves, I., Niculcea, A. S., Pacheco, P., Plachouras, D., Presterl, E., Quattrocolo, F., Reilly, J., Rydygier, L., Sartaj, M., Sarvikivi, E., Serban, R. I., Smid, E., Staniulyte, J., Stefkovicova, M., Strauss, R., Suetens, C., Vandael, E., Vilde, A., Weist, K., Zarb, P., Zingg, W., Zotti, C. M., Zupanc, T. L.   +69 more
core   +7 more sources

Refractory Cervical Necrotizing Fasciitis Successfully Controlled by Submandibular Gland Excision: A Case Report

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Persistent cervical necrotizing fasciitis may indicate an unrecognized infectious reservoir. In refractory cases, excision of a suspected salivary gland may be required to achieve definitive infection control when repeated debridement fails.
Hiroyuki Makihara, Shoichiro Kitajima, Sanae Maeda, Susumu Mizuno   +3 more
wiley   +1 more source

Antimicrobial Stewardship Intervention and Feedback to Infectious Disease Specialists: A Case Study in High-Dose Daptomycin

Antibiotics, 2015
Infectious Diseases specialists have used high-dose daptomycin (≥6 mg/kg/day) in select patients with difficult to treat methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus (VRE) infections to optimize outcomes ...
Jennifer L. Ross, Shannon Rankin, Patricia Marshik, Renée-Claude Mercier, Meghan Brett, Carla J. Walraven   +5 more
doaj   +1 more source