Results 41 to 50 of about 21,016 (175)

Daptomycin-nonsusceptible Staphylococcus aureus: the role of combination therapy with daptomycin and gentamicin [PDF]

, 2015
Reduced susceptibility to daptomycin in Staphylococcus aureus has now been described, leading to clinical failures. Here we determined the impact of daptomycin and gentamicin combination therapy on bactericidal activity and resistance emergence using ...
Peleg, Anton Y, Jhih-Hang Jiang, Jiang, Jhih-Hang, Anton Peleg   +3 more
core   +1 more source

Loss of LafB activity reverses daptomycin resistance in E. faecium

mBio
Infections caused by multidrug-resistant enterococci, particularly vancomycin-resistant Enterococcus (VRE), present significant therapeutic challenges. Daptomycin, a last-line treatment for VRE, often loses efficacy due to the emergence of resistance. In
Suelen Scarpa de Mello, Bailey Schultz, Byoungsook Goh, Alexandra Grote, Terrance Shea, Jacob Muscato, Sungwhan F. Oh, Abigail L. Manson, Ashlee M. Earl, Suzanne Walker, Ilana L. B. C. Camargo, Michael S. Gilmore   +11 more
doaj   +1 more source

Influence of the minimum inhibitory concentration of daptomycin on the outcomes of Staphylococcus aureus bacteraemia

Journal of Global Antimicrobial Resistance, 2021
Objectives: Recent studies have shown that methicillin-resistantStaphylococcus aureus (MRSA) bacteraemia with vancomycin minimum inhibitory concentration (MIC) >1 μg/mL is associated with a higher rate of treatment failure and a higher mortality rate ...
Hajar AlQahtani, Saeed Baloch, Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani, Deanne Tabb   +4 more
doaj   +1 more source

Daptomycin plus Fosfomycin versus Daptomycin Alone for Methicillin-Resistant Staphylococcus 2 aureus Bacteremia and Endocarditis. A Randomized Clinical Trial [PDF]

, 2022
Background We aimed to determine whether daptomycin plus fosfomycin provides higher treatment success than daptomycin alone for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and endocarditis. Methods A randomized (1:1) phase 3 superiority,
Puig Asensio, Mireia, Pintado, Vicente, Pigrau, Carles, Gasch, Oriol, Pujol Rojo, Miquel, Pasquau, Juan, López-Cortés, Luis Eduardo, Domínguez, María Ángeles, Miró Meda, José M. (José María), 1956-, Càmara, Jordi, Pujol, Miquel, Domínguez Luzón, Ma. Ángeles (María Ángeles), MRSA Bacteremia (BACSARM) Trial Investigators, García Pardo, Graciano, Tebé, Cristian, Videla, Sebastià, Shaw, Evelyn, Cuervo, Guillermo, Morata, Laura, Sanllorente, Mireia, Montero, Milagros, San Juan, Rafael, Montejo, Miguel, Escudero Sánchez, Rosa, Pasquau-Liaño, Juan, Andrés, Marta, López Cortés, Luis Eduardo, Escudero-Sánchez, Rosa, Padullés Zamora, Ariadna, Cuervo Requena, Guillermo, Puig-Asensio, M., Videla, Sebastián, Ferrer, Anna, Jover Sáenz, Alfredo, Càmara Mas, Jordi, López-Contreras, Joaquín, Pallarès, Natàlia, Pigrau, Carlos, García-Prado, Graciano, Aguado, José María, García-País, María José, Miró, José María, Jover-Sáenz, Alfredo, Murillas, Javier, Padullés, Ariadna, Rodriguez Álvarez, Regino, Rodríguez-Álvarez, Regino José, Carratalà, Jordi, López Contreras, Joaquín, Arenas, María del Mar, Arenas-Miras, Maria del Mar, Calbo, Esther, Garcia Pais, María Jose, Padilla, Belén, Hereu, Pilar   +54 more
core   +1 more source

Transcriptional Regulator DasR Represses Daptomycin Production through Both Direct and Cascade Mechanisms in Streptomyces roseosporus

Antibiotics, 2022
Daptomycin, produced by Streptomyces roseosporus, is a clinically important cyclic lipopeptide antibiotic used for the treatment of human infections caused by drug-resistant Gram-positive pathogens.
Qiong Chen, Jianya Zhu, Xingwang Li, Ying Wen   +3 more
doaj   +1 more source

Daptomycin: a novel lipopeptide antibiotic against Gram-positive pathogens

, 2010
Andres Beiras-Fernandez1,*, Ferdinand Vogt1,*, Ralf Sodian1, Florian Weis21Department of Cardiac Surgery, University Hospital Großhadern, Ludwig-Maximilian-University, Munich, Germany; 2Department of Anesthesiology, University Hospital Gro& ...
Ferdin, Florian Weis, Ralf Sodian, Andres Beiras-Fernandez, Vogt, et al.   +5 more
core   +1 more source

The effects of daptomycin on cell wall biosynthesis in Enterococcal faecalis

Scientific Reports, 2023
Daptomycin is a cyclic lipodepsipeptide antibiotic reserved for the treatment of serious infections by multidrug-resistant Gram-positive pathogens. Its mode of action is considered to be multifaceted, encompassing the targeting and depolarization of ...
Binayak Rimal, James Chang, Chengyin Liu, Raiyan Rashid, Manmilan Singh, Sung Joon Kim   +5 more
doaj   +1 more source

The Preparation of Novel Fluorenes Inspired by Hipposudoric Acid

Helvetica Chimica Acta, EarlyView.
In this research we report on the design and synthesis of a series of fluorene‐based derivatives loosely inspired by the tricyclic framework of hipposudoric acid. Preparation of sixteen novel N‐alkylated derivatives was accomplished via a series of concise one‐step amide N‐alkylation reactions.
Munib Uddin, Freya Harrison, Florida Koçi, Stephen P. Wren   +3 more
wiley   +1 more source

Intravascular Placement of A Nasogastric Tube: Clinical Presentation and Surgical Management

The Laryngoscope, EarlyView.
We report a rare case of inadvertent intravascular placement of a nasogastric tube following pharyngeal perforation, with extension through the internal jugular vein into the central venous system. Prompt radiological diagnosis and controlled surgical removal allowed successful management, highlighting the importance of early recognition and a ...
Matteo Alicandri‐Ciufelli, Daniele Marchioni, Alice Ruggieri, Samuele Baldelli, Lesley De Pietri   +4 more
wiley   +1 more source

Daptomycin Resistance in Clinical MRSA Strains Is Associated with a High Biological Fitness Cost

Frontiers in Microbiology, 2017
Daptomycin remains as one of the main treatment options for Methicillin-Resistant Staphylococcus aureus (MRSA). Sporadic resistance cases reported in patients treated with either daptomycin or glycopeptides are a growing concern.
Melanie Roch, Paula Gagetti, Paula Gagetti, James Davis, James Davis, Paola Ceriana, Laura Errecalde, Alejandra Corso, Adriana E. Rosato   +8 more
doaj   +1 more source