Results 21 to 30 of about 16,260 (155)

Treatment of bacteremia by vancomycin-resistant Enterococcus with daptomycin versus linezolid: a systematic review and meta-analyses

Iatreia, 2017
Introduction: Second-line drugs such as linezolid and daptomycin are used for treatment of vancomycin-resistant Enterococcus (VRE) infections. Objective: A systematic review to evaluate treatment of VRE bacteremia with linezolid versus daptomycin ...
Caicedo-Ochoa, Edgar Yaset, Urrutia-Gómez, Jorge Andrés, Fernández-Niño, Daniel Sebastián, Guío-Guerra, Santiago Alejandro, Méndez-Fandiño, Yardany Rafael   +4 more
doaj   +1 more source

Daptomycin: Local Application in Implant-Associated Infection and Complicated Osteomyelitis

The Scientific World Journal, 2012
Background. The rise of highly resistant bacteria creates a persistent urge to develop new antimicrobial agents. This paper investigates the application of the lipopeptide antibiotic daptomycin in infections involving the human bone. Methods. Compressive
Steffen B. Rosslenbroich, Michael J. Raschke, Carolin Kreis, Nancy Tholema-Hans, Andreas Uekoetter, Rudolf Reichelt, Thomas F. Fuchs   +6 more
doaj   +1 more source

Daptomycin to bone and joint infections and prosthesis joint infections: a systematic review

Brazilian Journal of Infectious Diseases, 2019
Backgroud: Daptomycin has been used in bone and joint infections (BJI) and prosthesis joint infections (PJI) considering spectrum of activity and biofilm penetration.
João Paulo Telles, Juliette Cieslinski, Felipe Francisco Tuon   +2 more
doaj   +1 more source

Elasnin Effectively Eradicates Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Biofilms

Microbiology Spectrum, 2022
Elasnin is a recently reported antibiofilm agent that is effective against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).
Jordy Evan Sulaiman, Lexin Long, Pei-Yuan Qian, Henry Lam   +3 more
doaj   +1 more source

Antibiotic Combinations Preventing Bacterial Resistance: Studies on an in vitro Model with Staphylococcus aureus Exposed to Linezolid–Daptomycin

Антибиотики и Химиотерапия, 2020
To predict the anti-mutant effects of antibiotic combinations against Staphylococcus aureus, the mutant prevention concentrations (MPCs) of linezolid and daptomycin were determined at a linezolid-to-daptomycin concentration ratio that corresponds to the ...
K. N. Alieva, M. V. Golikova, Y. A. Portnoy, A. A. Firsov   +3 more
doaj   +3 more sources

Population Pharmacokinetic/Pharmacodynamic Modelling of Daptomycin for Schedule Optimization in Patients with Renal Impairment

Pharmaceutics, 2022
The aims of this study are (i) to develop a population pharmacokinetic/pharmacodynamic model of daptomycin in patients with normal and impaired renal function, and (ii) to establish the optimal dose recommendation of daptomycin in clinical practice ...
Teresa García-Martínez, María Dolores Bellés-Medall, Maria García-Cremades, Raúl Ferrando-Piqueres, Victor Mangas-Sanjuán, Matilde Merino-Sanjuan   +5 more
doaj   +1 more source

Enhanced Antibacterial Properties of Lyotropic Liquid Crystalline Nanoparticles via Curvature Modulation

Advanced Science, EarlyView.
Lipid nanostructured particles with increasing negative Gaussian curvature progress from vesicles to P‐cubosomes and D‐cubosomes. This curvature hierarchy enhances interaction with bacterial membranes, promotes membrane remodeling and leakage, and potentiates daptomycin activity against MRSA.
Xiangfeng Lai, Shuhong Wang, Chenguang Ding, Xenia Kostoulias, Anton P. Le Brun, Hsien‐Yi Hsu, Jhih‐Hang Jiang, Yajun Wang, Richard A. Strugnell, Anton Y. Peleg, Hsin‐Hui Shen   +10 more
wiley   +1 more source

Influence of the minimum inhibitory concentration of daptomycin on the outcomes of Staphylococcus aureus bacteraemia

Journal of Global Antimicrobial Resistance, 2021
Objectives: Recent studies have shown that methicillin-resistantStaphylococcus aureus (MRSA) bacteraemia with vancomycin minimum inhibitory concentration (MIC) >1 μg/mL is associated with a higher rate of treatment failure and a higher mortality rate ...
Hajar AlQahtani, Saeed Baloch, Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani, Deanne Tabb   +4 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Loss of LafB activity reverses daptomycin resistance in E. faecium

mBio
Infections caused by multidrug-resistant enterococci, particularly vancomycin-resistant Enterococcus (VRE), present significant therapeutic challenges. Daptomycin, a last-line treatment for VRE, often loses efficacy due to the emergence of resistance. In
Suelen Scarpa de Mello, Bailey Schultz, Byoungsook Goh, Alexandra Grote, Terrance Shea, Jacob Muscato, Sungwhan F. Oh, Abigail L. Manson, Ashlee M. Earl, Suzanne Walker, Ilana L. B. C. Camargo, Michael S. Gilmore   +11 more
doaj   +1 more source