Results 31 to 40 of about 16,260 (155)
Antibiotics, 2022 Daptomycin, produced by Streptomyces roseosporus, is a clinically important cyclic lipopeptide antibiotic used for the treatment of human infections caused by drug-resistant Gram-positive pathogens.
Qiong Chen +3 more
doaj +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.Effect Probiotics on immune system modulation and wound Healing. ABSTRACT Introduction Burn wound infections caused by Acinetobacter baumannii remain a critical clinical challenge due to its extensive multidrug resistance, particularly against carbapenems.
Zeinab Fagheei Aghmiyuni +6 more
wiley +1 more source
Intravascular Placement of A Nasogastric Tube: Clinical Presentation and Surgical Management
The Laryngoscope, EarlyView.We report a rare case of inadvertent intravascular placement of a nasogastric tube following pharyngeal perforation, with extension through the internal jugular vein into the central venous system. Prompt radiological diagnosis and controlled surgical removal allowed successful management, highlighting the importance of early recognition and a ...
Matteo Alicandri‐Ciufelli +4 more
wiley +1 more source
The effects of daptomycin on cell wall biosynthesis in Enterococcal faecalis
Scientific Reports, 2023 Daptomycin is a cyclic lipodepsipeptide antibiotic reserved for the treatment of serious infections by multidrug-resistant Gram-positive pathogens. Its mode of action is considered to be multifaceted, encompassing the targeting and depolarization of ...
Binayak Rimal +5 more
doaj +1 more source
Cryo‐EM structures of multiple‐peptide resistance factor (MprF) from Pseudomonas aeruginosa
The FEBS Journal, EarlyView.Cryo‐EM analysis of MprF from Pseudomonas aeruginosa reveals a dimeric enzyme, distinct from Rhizobium homologues. The soluble GNAT domain contains a dynamic amphipathic helix (TTH) that adopts different positions in detergent micelle and nanodisc, relative to the membrane.
Shaileshanand Jha, Kutti R. Vinothkumar
wiley +1 more source
Daptomycin Resistance in Clinical MRSA Strains Is Associated with a High Biological Fitness Cost
Frontiers in Microbiology, 2017 Daptomycin remains as one of the main treatment options for Methicillin-Resistant Staphylococcus aureus (MRSA). Sporadic resistance cases reported in patients treated with either daptomycin or glycopeptides are a growing concern.
Melanie Roch +8 more
doaj +1 more source
The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1
The FEBS Journal, EarlyView.ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu +2 more
wiley +1 more source
Internal Medicine Journal, EarlyView.Abstract Background Staphylococcus lugdunensis is a coagulase‐negative Staphylococcus that has been increasingly recognised as a significant pathogen capable of causing invasive infections similar to Staphylococcus aureus. Data comparing the clinical manifestations and outcomes of S. lugdunensis bacteraemia to S. aureus bacteraemia remain limited. This
Gemma Webb +5 more
wiley +1 more source
PLoS ONE, 2012 BackgroundDaptomycin remains one of our last-line anti-staphylococcal agents. This study aims to characterize the genetic evolution to daptomycin resistance in S.
Anton Y Peleg +8 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 It has been suggested that daptomycin can be inactivated by lipids released by Staphylococcus aureus and that this effect is antagonized by phenol soluble modulins (PSMs), which bind to the shed lipids.
Tianwei Shen +4 more
doaj +1 more source