Results 31 to 40 of about 27,037 (216)

New Mutations in cls Lead to Daptomycin Resistance in a Clinical Vancomycin- and Daptomycin-Resistant Enterococcus faecium Strain

Frontiers in Microbiology, 2022
Daptomycin (DAP), a last-resort antibiotic for treating Gram-positive bacterial infection, has been widely used in the treatment of vancomycin-resistant enterococci (VRE).
Weiwei Li, Jiamin Hu, Ling Li, Mengge Zhang, Qingyu Cui, Ya-Nan Ma, H. Su, Xuhua Zhang, Hai Xu, Mingyu Wang   +9 more
semanticscholar   +1 more source

Cell Membrane Adaptations Mediate β-Lactam-Induced Resensitization of Daptomycin-Resistant (DAP-R) Staphylococcus aureus In Vitro

Microorganisms, 2021
The reversal of daptomycin resistance in MRSA to a daptomycin-susceptible phenotype following prolonged passage in selected β-lactams occurs coincident with the accumulation of multiple point mutations in the mprF gene.
Nagendra N. Mishra, Arnold S. Bayer, Sarah L. Baines, Ashleigh S. Hayes, Benjamin P. Howden, Christian K. Lapitan, Cassandra Lew, Warren E. Rose   +7 more
doaj   +1 more source

Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids

Nature Communications, 2020
The lipopeptide daptomycin is used as an antibiotic to treat severe infections with gram-positive pathogens, such as methicillin resistant Staphylococcus aureus (MRSA) and drug-resistant enterococci.
Fabian Grein, A. Müller, Katharina M. Scherer, Xinliang Liu, K. Ludwig, A. Klöckner, Manuel Strach, H. Sahl, U. Kubitscheck, T. Schneider   +9 more
semanticscholar   +1 more source

Catalase Protects Biofilm of Staphylococcus aureus against Daptomycin Activity

Antibiotics, 2021
Daptomycin is recommended for the treatment of Staphylococcus aureus infections due to its bactericidal activity. However, its mechanism of action is poorly understood.
Cristina El Haj, Mads Lichtenberg, Karen Leth Nielsen, Thomas Bjarnsholt, Peter Østrup Jensen   +4 more
doaj   +1 more source

The global prevalence of Daptomycin, Tigecycline, Quinupristin/Dalfopristin, and Linezolid-resistant Staphylococcus aureus and coagulase–negative staphylococci strains: a systematic review and meta-analysis

Antimicrobial Resistance and Infection Control, 2020
Methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococcus (MRCoNS) are among the main causes of nosocomial infections, which have caused major problems in recent years due to continuously increasing ...
A. Shariati, M. Dadashi, Z. Chegini, A. van Belkum, M. Mirzaii, S. Khoramrooz, D. Darban-Sarokhalil   +6 more
semanticscholar   +1 more source

Eosinophilic Syndromes Associated With Daptomycin Use: Re-exposure Hypersensitivity Pneumonitis and Prior Peripheral Eosinophilia

Open Forum Infectious Diseases, 2022
Background Daptomycin pulmonary eosinophilia (DPE) has been well described in case reports and reporting from the Food and Drug Administration. We report 3 eosinophilic syndromes associated with daptomycin use.
K. West, Ahmed Sheeti, Kimberly Tamura MacKay, G. Forrest   +3 more
semanticscholar   +1 more source

Daptomycin versus Vancomycin for the Treatment of Methicillin-Resistant Staphylococcus aureus Bloodstream Infection with or without Endocarditis: A Systematic Review and Meta-Analysis

Antibiotics, 2021
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of invasive infections, mainly bloodstream infections (BSI) with or without endocarditis.
A. Maraolo, A. Giaccone, I. Gentile, A. Saracino, D. Bavaro   +4 more
semanticscholar   +1 more source

Daptomycin exerts bactericidal effect through induction of excessive ROS production and blocking the function of stress response protein Usp2

Natural Sciences, 2021
Daptomycin, as a lipopeptide antibiotic, exhibits high potency in the treatment of infections caused by clinically relevant drug‐resistant Gram‐positive pathogens, such as methicillin‐resistant Staphylococcus aureus and vancomycin‐resistant Enterococci ...
Kathy Hiu Laam Po, Hoi Yee Chow, Qipeng Cheng, Bill Kwan‐wai Chan, Xin Deng, Shuping Wang, Edward Wai Chi Chan, Hang‐Kin Kong, Kin Fai Chan, Xuechen Li, Sheng Chen   +10 more
doaj   +1 more source

Comparative Effectiveness of Switching to Daptomycin Versus Remaining on Vancomycin Among Patients with Methicillin-resistant Staphylococcus aureus (MRSA) Bloodstream Infections

Clinical Infectious Diseases, 2021
Background: Patients with methicillin-resistant Staphylococcus aureus bloodstream infections (MRSA BSI) usually receive initial treatment with vancomycin but may be switched to daptomycin for definitive therapy, especially if treatment failure is ...
Marin L. Schweizer, K. Richardson, M. V. Vaughan Sarrazin, Michihiko Goto, D. Livorsi, R. Nair, Bruce H. Alexander, Brice F. Beck, Michael P Jones, M. Puig-Asensio, Daniel Suh, Madeline Ohl, E. Perencevich   +12 more
semanticscholar   +1 more source

A High Daptomycin Dose Is Associated with Better Bacterial Clearance in Infections Caused by Vancomycin-Resistant Enterococcus faecium Regardless of Daptomycin Minimum Inhibitory Concentration in a Rat Infective Endocarditis Model

Microbiology Spectrum, 2022
A high daptomycin dose has been suggested for treating vancomycin-resistant Enterococcus faecium (VREf) infections. However, even a 12 mg/kg daptomycin dose might be insufficient for treating VREf with high daptomycin minimum inhibitory concentrations ...
Jann-Tay Wang, Chia-Jui Yang, Jia-Ling Yang, Shu-Wen Lin, Yu-Chung Chuang, Wang-Huei Sheng, Yee-Chun Chen, Shan-Chwen Chang   +7 more
doaj   +1 more source