Results 31 to 40 of about 29,458 (191)

Daptomycin: Local Application in Implant-Associated Infection and Complicated Osteomyelitis

The Scientific World Journal, 2012
Background. The rise of highly resistant bacteria creates a persistent urge to develop new antimicrobial agents. This paper investigates the application of the lipopeptide antibiotic daptomycin in infections involving the human bone. Methods. Compressive
Steffen B. Rosslenbroich, Michael J. Raschke, Carolin Kreis, Nancy Tholema-Hans, Andreas Uekoetter, Rudolf Reichelt, Thomas F. Fuchs   +6 more
doaj   +1 more source

Treatment of bacteremia by vancomycin-resistant Enterococcus with daptomycin versus linezolid: a systematic review and meta-analyses

Iatreia, 2017
Introduction: Second-line drugs such as linezolid and daptomycin are used for treatment of vancomycin-resistant Enterococcus (VRE) infections. Objective: A systematic review to evaluate treatment of VRE bacteremia with linezolid versus daptomycin ...
Caicedo-Ochoa, Edgar Yaset, Urrutia-Gómez, Jorge Andrés, Fernández-Niño, Daniel Sebastián, Guío-Guerra, Santiago Alejandro, Méndez-Fandiño, Yardany Rafael   +4 more
doaj   +1 more source

An in vitro evaluation of the efficacy of tedizolid: implications for the treatment of skin and soft tissue infections [PDF]

, 2018
Skin and soft tissue infections (SSTI) are among the most commonly occurring infections and evidence suggests that these are increasing world-wide.
Aleryan, Muna, Delpech, Pierre, Gemmell, Curtis, Jones, Brian, Lang, Susan   +4 more
core   +2 more sources

Daptomycin to bone and joint infections and prosthesis joint infections: a systematic review

Brazilian Journal of Infectious Diseases, 2019
Backgroud: Daptomycin has been used in bone and joint infections (BJI) and prosthesis joint infections (PJI) considering spectrum of activity and biofilm penetration.
João Paulo Telles, Juliette Cieslinski, Felipe Francisco Tuon   +2 more
doaj   +1 more source

Elasnin Effectively Eradicates Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Biofilms

Microbiology Spectrum, 2022
Elasnin is a recently reported antibiofilm agent that is effective against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).
Jordy Evan Sulaiman, Lexin Long, Pei-Yuan Qian, Henry Lam   +3 more
doaj   +1 more source

Antibiotic Combinations Preventing Bacterial Resistance: Studies on an in vitro Model with Staphylococcus aureus Exposed to Linezolid–Daptomycin

Антибиотики и Химиотерапия, 2020
To predict the anti-mutant effects of antibiotic combinations against Staphylococcus aureus, the mutant prevention concentrations (MPCs) of linezolid and daptomycin were determined at a linezolid-to-daptomycin concentration ratio that corresponds to the ...
K. N. Alieva, M. V. Golikova, Y. A. Portnoy, A. A. Firsov   +3 more
doaj   +3 more sources

Population Pharmacokinetic/Pharmacodynamic Modelling of Daptomycin for Schedule Optimization in Patients with Renal Impairment

Pharmaceutics, 2022
The aims of this study are (i) to develop a population pharmacokinetic/pharmacodynamic model of daptomycin in patients with normal and impaired renal function, and (ii) to establish the optimal dose recommendation of daptomycin in clinical practice ...
Teresa García-Martínez, María Dolores Bellés-Medall, Maria García-Cremades, Raúl Ferrando-Piqueres, Victor Mangas-Sanjuán, Matilde Merino-Sanjuan   +5 more
doaj   +1 more source

Antimicrobial Cyclic Peptidomimetics

Macromolecular Rapid Communications, EarlyView.
Singular macromolecular cationic, amphipathic cyclic peptidomimetics with poly(2‐oxazoline)s‐esque backbone structure that undergo self‐assembly in water to form uniform nanoparticles were developed. The cyclic peptidomimetics, which act on bacterial cell membranes, exhibit hydrophobic‐dependent antimicrobial activity and toxicity.
Hao Luo, Edgar H. H. Wong
wiley   +1 more source

Loss of LafB activity reverses daptomycin resistance in E. faecium

mBio
Infections caused by multidrug-resistant enterococci, particularly vancomycin-resistant Enterococcus (VRE), present significant therapeutic challenges. Daptomycin, a last-line treatment for VRE, often loses efficacy due to the emergence of resistance. In
Suelen Scarpa de Mello, Bailey Schultz, Byoungsook Goh, Alexandra Grote, Terrance Shea, Jacob Muscato, Sungwhan F. Oh, Abigail L. Manson, Ashlee M. Earl, Suzanne Walker, Ilana L. B. C. Camargo, Michael S. Gilmore   +11 more
doaj   +1 more source

Transcriptional Regulator DasR Represses Daptomycin Production through Both Direct and Cascade Mechanisms in Streptomyces roseosporus

Antibiotics, 2022
Daptomycin, produced by Streptomyces roseosporus, is a clinically important cyclic lipopeptide antibiotic used for the treatment of human infections caused by drug-resistant Gram-positive pathogens.
Qiong Chen, Jianya Zhu, Xingwang Li, Ying Wen   +3 more
doaj   +1 more source