Results 51 to 60 of about 21,016 (175)

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of Staphylococcus aureus.

PLoS ONE, 2012
BackgroundDaptomycin remains one of our last-line anti-staphylococcal agents. This study aims to characterize the genetic evolution to daptomycin resistance in S.
Anton Y Peleg, Spiros Miyakis, Doyle V Ward, Ashlee M Earl, Aileen Rubio, David R Cameron, Satish Pillai, Robert C Moellering, George M Eliopoulos   +8 more
doaj   +1 more source

Varied Contribution of Phospholipid Shedding From Membrane to Daptomycin Tolerance in Staphylococcus aureus

Frontiers in Molecular Biosciences, 2021
It has been suggested that daptomycin can be inactivated by lipids released by Staphylococcus aureus and that this effect is antagonized by phenol soluble modulins (PSMs), which bind to the shed lipids.
Tianwei Shen, Kelly M. Hines, Nathaniel K. Ashford, Brian J. Werth, Libin Xu   +4 more
doaj   +1 more source

Engineered surface strategies to manage dental implant‐related infections

Periodontology 2000, EarlyView.
Abstract When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant‐related infections—one of the main causes of implant failure. These failures impose significant costs on patients, clinicians, and healthcare systems.
João Gabriel S. Souza, Bruna E. Nagay, Rodrigo Martins, Martinna Bertolini, Jamil A. Shibli, Conrado Aparicio, Magda Feres, Valentim A. R. Barão   +7 more
wiley   +1 more source

Daptomycin Exposure as a Risk Factor for Daptomycin-Induced Eosinophilic Pneumonia and Muscular Toxicity

, 2023
Background High-dose daptomycin is increasingly used in patients with bone and joint infection (BJI). This raises concerns about a higher risk of adverse events (AEs), including daptomycin-induced eosinophilic pneumonia (DIEP) and myotoxicity.
Ferry, Tristan, Bourguignon, Laurent, Pham, Truong-Thanh, Goutelle, Sylvain, Parant, François, Desevre, Marine, Garreau, Romain, Millet, Aurélien, Franchi, Victor, Bussy, David   +9 more
core   +1 more source

Assessment of invitrosynergy of daptomycin or vancomycin plus ceftaroline for daptomycin non-susceptible Staphylococcus aureus [PDF]

, 2020
The combination of vancomycin or daptomycin plus ceftaroline has showed synergistic results in vitro. This study aimed to investigate in vitro synergy of vancomycin or daptomycin plus ceftaroline for seven patients with daptomycin non-susceptible ...
Herc, Erica, Sundaram, Ayesha, Hutton, Mary A, Perri, Mary B, Zervos, Marcus J   +4 more
core   +1 more source

Daptomycin: a comparison of two intravenous formulations

Drug Design, Development and Therapy, 2018
Celeste Frankenfeld, Sachin Mittal, Yanira Melendez, Luke Mendez-Vigo, Kenneth C Lamp, Kaitlin N Keller, Shellie R Bertolami Merck & Co., Inc., Kenilworth, NJ, USA Abstract: Daptomycin is a cyclic lipopeptide antibacterial agent with potent ...
Frankenfeld C, Mittal S, Melendez Y, Mendez-Vigo L, Lamp KC, Keller KN, Bertolami SR   +6 more
doaj  

Antimicrobial Stewardship Intervention and Feedback to Infectious Disease Specialists: A Case Study in High-Dose Daptomycin

Antibiotics, 2015
Infectious Diseases specialists have used high-dose daptomycin (≥6 mg/kg/day) in select patients with difficult to treat methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus (VRE) infections to optimize outcomes ...
Jennifer L. Ross, Shannon Rankin, Patricia Marshik, Renée-Claude Mercier, Meghan Brett, Carla J. Walraven   +5 more
doaj   +1 more source

Oligomerization of daptomycin on membranes [PDF]

, 2011
Daptomycin is a lipopeptide antibiotic that kills Gram-positive bacteria by membrane depolarization. While it has long been assumed that the mode of action of daptomycin involves the formation of membrane-associated oligomers, this has so far not been ...
Jawad K. Muraih, Jared Silverman, Muraih, Jawad K., Silverman, Jared, Andre Pearson, Palmer, Michael, Pearson, Andre, Michael Palmer   +7 more
core   +1 more source

Daptomycin treatment impacts resistance in off-target populations of vancomycin-resistant Enterococcus faecium.

PLoS Biology, 2020
The antimicrobial resistance crisis has persisted despite broad attempts at intervention. It has been proposed that an important driver of resistance is selection imposed on bacterial populations that are not the intended target of antimicrobial therapy.
Clare L Kinnear, Elsa Hansen, Valerie J Morley, Kevin C Tracy, Meghan Forstchen, Andrew F Read, Robert J Woods   +6 more
doaj   +1 more source