Results 11 to 20 of about 21,016 (175)

Daptomycin-Induced Posterior Reversible Encephalopathy Syndrome (PRES)

Case Reports in Neurological Medicine, 2019
Aims. To present a 60-year-old female patient who manifested clinical and radiological features of posterior reversible encephalopathy syndrome (PRES) following the administration of Daptomycin for glycopeptide-resistant Enterococcal urinary tract ...
A. Bitar De Zayas-Enriquez, C. Soper
doaj   +2 more sources

Daptomycin resistance of Corynebacterium jeikeium due to pgsA gene mutation acquired during daptomycin treatment in a patient with infective endocarditis

International Journal of Infectious Diseases
Daptomycin is an alternative agent for invasive infections caused by Corynebacterium species in patients with intolerance to vancomycin. Although it has recently been recognized that treatment failure with daptomycin due to the emergence of resistant ...
Makoto Inada, Kohji Komori, Sohei Harada, Shinya Yamamoto, Koh Okamoto, Ayano Nakazato, Yoshimi Higurashi, Shuhei Matsumoto, Junji Tokushige, Arika Shimura, Takeya Tsutsumi   +10 more
doaj   +2 more sources

De Novo Daptomycin-Nonsusceptible Enterococcal Infections

Emerging Infectious Diseases, 2012
Potential emergence of enterococcal daptomycin nonsusceptibility among patients with no prior exposure to daptomycin poses clinical and public health challenges.
Theodoros Kelesidis, Romney Humphries, Daniel Z. Uslan, David Pegues   +3 more
doaj   +2 more sources

Catalase Protects Biofilm of Staphylococcus aureus against Daptomycin Activity

Antibiotics, 2021
Daptomycin is recommended for the treatment of Staphylococcus aureus infections due to its bactericidal activity. However, its mechanism of action is poorly understood.
Cristina El Haj, Mads Lichtenberg, Karen Leth Nielsen, Thomas Bjarnsholt, Peter Østrup Jensen   +4 more
doaj   +1 more source

Daptomycin exerts bactericidal effect through induction of excessive ROS production and blocking the function of stress response protein Usp2

Natural Sciences, 2021
Daptomycin, as a lipopeptide antibiotic, exhibits high potency in the treatment of infections caused by clinically relevant drug‐resistant Gram‐positive pathogens, such as methicillin‐resistant Staphylococcus aureus and vancomycin‐resistant Enterococci ...
Kathy Hiu Laam Po, Hoi Yee Chow, Qipeng Cheng, Bill Kwan‐wai Chan, Xin Deng, Shuping Wang, Edward Wai Chi Chan, Hang‐Kin Kong, Kin Fai Chan, Xuechen Li, Sheng Chen   +10 more
doaj   +1 more source

A High Daptomycin Dose Is Associated with Better Bacterial Clearance in Infections Caused by Vancomycin-Resistant Enterococcus faecium Regardless of Daptomycin Minimum Inhibitory Concentration in a Rat Infective Endocarditis Model

Microbiology Spectrum, 2022
A high daptomycin dose has been suggested for treating vancomycin-resistant Enterococcus faecium (VREf) infections. However, even a 12 mg/kg daptomycin dose might be insufficient for treating VREf with high daptomycin minimum inhibitory concentrations ...
Jann-Tay Wang, Chia-Jui Yang, Jia-Ling Yang, Shu-Wen Lin, Yu-Chung Chuang, Wang-Huei Sheng, Yee-Chun Chen, Shan-Chwen Chang   +7 more
doaj   +1 more source

Physiologically based pharmacokinetic modeling of daptomycin dose optimization in pediatric patients with renal impairment

Frontiers in Pharmacology, 2022
Background and Objective: Daptomycin is used to treat Gram-positive infections in adults and children and its dosing varies among different age groups. We focused on the pharmacokinetics of daptomycin in children with renal impairment, which has not been
Lingling Ye, Xiang You, Jie Zhou, Chaohui Wu, Meng Ke, Wanhong Wu, Pinfang Huang, Cuihong Lin   +7 more
doaj   +1 more source

In Vivo Efficacy of Daptomycin against Methicillin-Resistant Staphylococcus aureus in a Mouse Model of Hematogenous Pulmonary Infection [PDF]

, 2013
Daptomycin is inactivated by pulmonary surfactant, but its effectiveness in hematogenous pulmonary infection has been poorly studied. The potential therapeutic application was evaluated in a methicillin-resistant Staphylococcus aureus (MRSA) hematogenous
Yamada, Koichi, Kakeya, Hiroshi, 原田, 陽介, Imamura, Yoshifumi, Miyazaki, Taiga, Hasegawa, Hiroo, Yanagihara, Katsunori, Nagaoka, Kentaro, Kohno, Shigeru, Nakamura, Shigeki, Izumikawa, Koichi, Migiyama, Yohei, Harada, Yosuke, Morinaga, Yoshitomo   +13 more
core   +1 more source

Investigating Daptomycin–Membrane Interactions Using Native MS and Fast Photochemical Oxidation of Peptides in Nanodiscs [PDF]

, 2023
Daptomycin is a cyclic lipopeptide antibiotic that targets the lipid membrane of Gram-positive bacteria. Membrane fluidity and charge can affect daptomycin activity, but its mechanisms are poorly understood because it is challenging to study daptomycin ...
Michael, Marty, Deseree J. Reid (4529644), Craig A. Aspinwall (1347870), Zhihan Wang (1675384), Michael T. Marty (7822148), Craig, Aspinwall, Tapasyatanu Dash (14762436), Tapasyatanu, Dash, Zhihan , Wang, Deseree, Reid   +9 more
core   +2 more sources

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources