Results 11 to 20 of about 27,037 (216)

Acquisition of Daptomycin Resistance by Enterococcus faecium Confers Collateral Sensitivity to Glycopeptides

Frontiers in Microbiology, 2022
Daptomycin is a last-line antibiotic used in the treatment of multidrug-resistant Enterococcus faecium infections. Alarmingly, daptomycin-resistant E. faecium isolates have emerged.
Weiliang Zeng, Changrui Qian, Lingbo Wang   +2 more
exaly   +4 more sources

The Combination of Daptomycin with Fosfomycin is More Effective than Daptomycin Alone in Reducing Mortality of Vancomycin-Resistant Enterococcal Bloodstream Infections: A Retrospective, Comparative Cohort Study

Infectious Diseases and Therapy, 2023
Introduction High-dose daptomycin-based combinations are recommended for vancomycin-resistant Enterococcus (VRE) bloodstream infection (BSI). Preclinical data have shown a synergistic effect of daptomycin/fosfomycin combinations against VRE.
Tai-Chung Tseng, Yu-Chung Chuang, Jia-Ling Yang, Chi-Ying Lin, Sung-Hsi Huang, Jann-Tay Wang, Yee-Chun Chen, Shan-Chwen Chang   +7 more
doaj   +2 more sources

Daptomycin Resistance Occurs Predominantly in vanA-Type Vancomycin-Resistant Enterococcus faecium in Australasia and Is Associated With Heterogeneous and Novel Mutations

Frontiers in Microbiology, 2021
Healthcare associated infections caused by vancomycin-resistant Enterococcus faecium (VREfm) have a major impact on health outcomes. VREfm is difficult to treat because of intrinsic and acquired resistance to many clinically used antimicrobials, with ...
Lucy Li, Charlie Higgs, Adrianna M. Turner, Yi Nong, Claire L. Gorrie, Claire L. Gorrie, Norelle L. Sherry, Norelle L. Sherry, Norelle L. Sherry, Kristin H. Dyet, Torsten Seemann, Deborah A. Williamson, Deborah A. Williamson, Timothy P. Stinear, Benjamin P. Howden, Benjamin P. Howden, Benjamin P. Howden, Glen P. Carter, Glen P. Carter   +18 more
doaj   +2 more sources

Daptomycin Exposure as a Risk Factor for Daptomycin-Induced Eosinophilic Pneumonia and Muscular Toxicity.

Clinical Infectious Diseases, 2023
BACKGROUND High-dose daptomycin is increasingly used in patients with bone and joint infection (BJI). This raises concerns about a higher risk of adverse events (AEs), including daptomycin-induced eosinophilic pneumonia (DIEP) and myotoxicity.
R. Garreau, Truong-Thanh Pham, L. Bourguignon, Aurélien Millet, F. Parant, David Bussy, Marine Desevre, Victor Franchi, T. Ferry, S. Goutelle   +9 more
semanticscholar   +2 more sources

Daptomycin Plus Fosfomycin Versus Daptomycin Alone for Methicillin-resistant Staphylococcus aureus Bacteremia and Endocarditis: A Randomized Clinical Trial [PDF]

Clinical Infectious Diseases, 2020
Background We aimed to determine whether daptomycin plus fosfomycin provides higher treatment success than daptomycin alone for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and endocarditis. Methods A randomized (1:1) phase 3 superiority,
M. Pujol, J. Miro, E. Shaw, J. Aguado, R. San-Juan, M. Puig-Asensio, C. Pigrau, E. Calbo, M. Montejo, R. Rodríguez-Álvarez, M. García-País, V. Pintado, R. Escudero-Sánchez, J. López-Contreras, L. Morata, M. Montero, M. Andrés, J. Pasquau, M. Arenas, B. Padilla, J. Murillas, A. Jover-Sáenz, L. López-Cortés, G. García-Pardo, O. Gasch, S. Videla, P. Hereu, C. Tebé, N. Pallarès, M. Sanllorente, M. Domínguez, J. Càmara, A. Ferrer, A. Padullés, G. Cuervo, J. Carratalá, Á. Soriano, M. Almela, Frédéric Gomez, F. Chávez, B. Mirelis, E. Padilla, Maria Dolores Pérez-Ramírez, M. Espasa, Ana Maria Sánchez-Díaz, E. Cercenado, E. Ruíz de Gopegui, Ana Siverio, M. de Cueto, F. García-Garrote, M. García, M. Xercavins, María Nieves Larrosa   +52 more
semanticscholar   +2 more sources

Therapeutic drug monitoring of daptomycin in a critically ill patient cohort [PDF]

Frontiers in Medicine
BackgroundPharmacokinetics of antimicrobial agents are altered in critically ill patients. Therefore, therapeutic drug monitoring (TDM) has gained much attention in recent years.
Rubi Stephani Hellwege, Mattia Müller, Rolf Erlebach, Onur Sazpinar, Alix Buhlmann, Reto A. Schuepbach, Sascha David, Sascha David, Daniel A. Hofmaenner   +8 more
doaj   +2 more sources

Comparative effectiveness of daptomycin versus vancomycin among patients with methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections: A systematic literature review and meta-analysis.

PLoS ONE
BackgroundIn the treatment of methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSIs), vancomycin stands as the prevalent therapeutic agent.
Yau Adamu, Mireia Puig-Asensio, Bashir Dabo, Marin L Schweizer   +3 more
doaj   +2 more sources

Clinical Pharmacokinetics of Daptomycin

Clinical Pharmacokinetics, 2020
International audienceDue to the low level of resistance observed with daptomycin, this antibiotic has an important place in the treatment of severe Gram-positive infections.
N. Grégoire, A. Chauzy, J. Buyck, B. Rammaert, W. Couet, S. Marchand   +5 more
semanticscholar   +2 more sources

Daptomycin [PDF]

Journal of Antimicrobial Chemotherapy, 2017
Daptomycin is a cyclic lipopeptide antibiotic used for the treatment of Gram-positive infections including complicated skin and skin structure infections, right-sided infective endocarditis, bacteraemia, meningitis, sepsis and urinary tract infections.
Mohsen, Heidary, Azar Dohkt, Khosravi, Saeed, Khoshnood, Mohammad Javad, Nasiri, Saleh, Soleimani, Mehdi, Goudarzi   +5 more
  +9 more sources

Daptomycin-Induced Posterior Reversible Encephalopathy Syndrome (PRES)

Case Reports in Neurological Medicine, 2019
Aims. To present a 60-year-old female patient who manifested clinical and radiological features of posterior reversible encephalopathy syndrome (PRES) following the administration of Daptomycin for glycopeptide-resistant Enterococcal urinary tract ...
A. Bitar De Zayas-Enriquez, C. Soper
doaj   +2 more sources