Results 11 to 20 of about 29,458 (191)

The Combination of Daptomycin with Fosfomycin is More Effective than Daptomycin Alone in Reducing Mortality of Vancomycin-Resistant Enterococcal Bloodstream Infections: A Retrospective, Comparative Cohort Study

Infectious Diseases and Therapy, 2023
Introduction High-dose daptomycin-based combinations are recommended for vancomycin-resistant Enterococcus (VRE) bloodstream infection (BSI). Preclinical data have shown a synergistic effect of daptomycin/fosfomycin combinations against VRE.
Tai-Chung Tseng, Yu-Chung Chuang, Jia-Ling Yang, Chi-Ying Lin, Sung-Hsi Huang, Jann-Tay Wang, Yee-Chun Chen, Shan-Chwen Chang   +7 more
doaj   +1 more source

Cell Membrane Adaptations Mediate β-Lactam-Induced Resensitization of Daptomycin-Resistant (DAP-R) Staphylococcus aureus In Vitro

Microorganisms, 2021
The reversal of daptomycin resistance in MRSA to a daptomycin-susceptible phenotype following prolonged passage in selected β-lactams occurs coincident with the accumulation of multiple point mutations in the mprF gene.
Nagendra N. Mishra, Arnold S. Bayer, Sarah L. Baines, Ashleigh S. Hayes, Benjamin P. Howden, Christian K. Lapitan, Cassandra Lew, Warren E. Rose   +7 more
doaj   +1 more source

Catalase Protects Biofilm of Staphylococcus aureus against Daptomycin Activity

Antibiotics, 2021
Daptomycin is recommended for the treatment of Staphylococcus aureus infections due to its bactericidal activity. However, its mechanism of action is poorly understood.
Cristina El Haj, Mads Lichtenberg, Karen Leth Nielsen, Thomas Bjarnsholt, Peter Østrup Jensen   +4 more
doaj   +1 more source

Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms. [PDF]

, 2020
Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S.
Allan, RN, Angus, EM, Coates, ARM, Frapwell, CJ, Howlin, RP, Hu, Y, Skipp, PJ, Webb, JS   +7 more
core   +2 more sources

Daptomycin exerts bactericidal effect through induction of excessive ROS production and blocking the function of stress response protein Usp2

Natural Sciences, 2021
Daptomycin, as a lipopeptide antibiotic, exhibits high potency in the treatment of infections caused by clinically relevant drug‐resistant Gram‐positive pathogens, such as methicillin‐resistant Staphylococcus aureus and vancomycin‐resistant Enterococci ...
Kathy Hiu Laam Po, Hoi Yee Chow, Qipeng Cheng, Bill Kwan‐wai Chan, Xin Deng, Shuping Wang, Edward Wai Chi Chan, Hang‐Kin Kong, Kin Fai Chan, Xuechen Li, Sheng Chen   +10 more
doaj   +1 more source

A High Daptomycin Dose Is Associated with Better Bacterial Clearance in Infections Caused by Vancomycin-Resistant Enterococcus faecium Regardless of Daptomycin Minimum Inhibitory Concentration in a Rat Infective Endocarditis Model

Microbiology Spectrum, 2022
A high daptomycin dose has been suggested for treating vancomycin-resistant Enterococcus faecium (VREf) infections. However, even a 12 mg/kg daptomycin dose might be insufficient for treating VREf with high daptomycin minimum inhibitory concentrations ...
Jann-Tay Wang, Chia-Jui Yang, Jia-Ling Yang, Shu-Wen Lin, Yu-Chung Chuang, Wang-Huei Sheng, Yee-Chun Chen, Shan-Chwen Chang   +7 more
doaj   +1 more source

Effect of Concomitant 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Inhibitor Therapy on Creatine Phosphokinase Levels and Mortality Among Patients Receiving Daptomycin: Retrospective Cohort Study. [PDF]

, 2014
IntroductionThe prescribing information for daptomycin recommends discontinuing statin therapy during receipt of daptomycin. The literature supporting this recommendation is sparse.
Lodise, Thomas, Lowry, Colleen, McConnell, Heather L, Patel, Nimish, Perris, Elizabeth T   +4 more
core   +1 more source

Effect of daptomycin and vancomycin on Staphylococcus epidermidis biofilms: An in vitro assessment using fluorescence in situ hybridization [PDF]

, 2019
Colonization of in-dwelling catheters by microbial biofilms is a major concern in patient health eventually leading to catheter-related blood stream infections.
Affeld, Klaus, Gabel, Grischa, Gebhardt, M., Goubergrits, Leonid, Kertzscher, Ulrich, Kikhney, Judith, Kursawe, Laura, Moter, Annette, Petrich, A., Schmidt, Julia, Sutrave, Smita, Wiessner, Alexandra   +11 more
core   +1 more source

Physiologically based pharmacokinetic modeling of daptomycin dose optimization in pediatric patients with renal impairment

Frontiers in Pharmacology, 2022
Background and Objective: Daptomycin is used to treat Gram-positive infections in adults and children and its dosing varies among different age groups. We focused on the pharmacokinetics of daptomycin in children with renal impairment, which has not been
Lingling Ye, Xiang You, Jie Zhou, Chaohui Wu, Meng Ke, Wanhong Wu, Pinfang Huang, Cuihong Lin   +7 more
doaj   +1 more source

When good bugs go bad: Epidemiology and antimicrobial resistance profiles of Corynebacterium striatum, an emerging multidrug-resistant, opportunistic pathogen [PDF]

, 2017
Infections with Corynebacterium striatum have been described in the literature over the last 2 decades, with the majority being bacteremia, central line infections, and occasionally, endocarditis.
Anderson, Neil, Burnham, Carey-Ann D, McMullen, Allison R, Shupe, Angela, Wallace, Meghan A   +4 more
core   +2 more sources