Results 11 to 20 of about 16,260 (155)

The Combination of Daptomycin with Fosfomycin is More Effective than Daptomycin Alone in Reducing Mortality of Vancomycin-Resistant Enterococcal Bloodstream Infections: A Retrospective, Comparative Cohort Study

Infectious Diseases and Therapy, 2023
Introduction High-dose daptomycin-based combinations are recommended for vancomycin-resistant Enterococcus (VRE) bloodstream infection (BSI). Preclinical data have shown a synergistic effect of daptomycin/fosfomycin combinations against VRE.
Tai-Chung Tseng, Yu-Chung Chuang, Jia-Ling Yang, Chi-Ying Lin, Sung-Hsi Huang, Jann-Tay Wang, Yee-Chun Chen, Shan-Chwen Chang   +7 more
doaj   +1 more source

Catalase Protects Biofilm of Staphylococcus aureus against Daptomycin Activity

Antibiotics, 2021
Daptomycin is recommended for the treatment of Staphylococcus aureus infections due to its bactericidal activity. However, its mechanism of action is poorly understood.
Cristina El Haj, Mads Lichtenberg, Karen Leth Nielsen, Thomas Bjarnsholt, Peter Østrup Jensen   +4 more
doaj   +1 more source

Daptomycin exerts bactericidal effect through induction of excessive ROS production and blocking the function of stress response protein Usp2

Natural Sciences, 2021
Daptomycin, as a lipopeptide antibiotic, exhibits high potency in the treatment of infections caused by clinically relevant drug‐resistant Gram‐positive pathogens, such as methicillin‐resistant Staphylococcus aureus and vancomycin‐resistant Enterococci ...
Kathy Hiu Laam Po, Hoi Yee Chow, Qipeng Cheng, Bill Kwan‐wai Chan, Xin Deng, Shuping Wang, Edward Wai Chi Chan, Hang‐Kin Kong, Kin Fai Chan, Xuechen Li, Sheng Chen   +10 more
doaj   +1 more source

A High Daptomycin Dose Is Associated with Better Bacterial Clearance in Infections Caused by Vancomycin-Resistant Enterococcus faecium Regardless of Daptomycin Minimum Inhibitory Concentration in a Rat Infective Endocarditis Model

Microbiology Spectrum, 2022
A high daptomycin dose has been suggested for treating vancomycin-resistant Enterococcus faecium (VREf) infections. However, even a 12 mg/kg daptomycin dose might be insufficient for treating VREf with high daptomycin minimum inhibitory concentrations ...
Jann-Tay Wang, Chia-Jui Yang, Jia-Ling Yang, Shu-Wen Lin, Yu-Chung Chuang, Wang-Huei Sheng, Yee-Chun Chen, Shan-Chwen Chang   +7 more
doaj   +1 more source

Physiologically based pharmacokinetic modeling of daptomycin dose optimization in pediatric patients with renal impairment

Frontiers in Pharmacology, 2022
Background and Objective: Daptomycin is used to treat Gram-positive infections in adults and children and its dosing varies among different age groups. We focused on the pharmacokinetics of daptomycin in children with renal impairment, which has not been
Lingling Ye, Xiang You, Jie Zhou, Chaohui Wu, Meng Ke, Wanhong Wu, Pinfang Huang, Cuihong Lin   +7 more
doaj   +1 more source

A study on combination of daptomycin with selected antimicrobial agents: in vitro synergistic effect of MIC value of 1 mg/L against MRSA strains

BMC Pharmacology and Toxicology, 2019
Background Daptomycin is an important drug used in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection. A high dose of daptomycin is indicated for an MRSA infection with a minimum inhibitory concentration (MIC) of 1 mg/L for ...
Yi-Chien Lee, Pao-Yu Chen, Jann-Tay Wang, Shan-Chwen Chang   +3 more
doaj   +1 more source

Antimicrobial potency, prevention ability, and killing efficacy of daptomycin-loaded versus vancomycin-loaded β-tricalcium phosphate/calcium sulfate for methicillin-resistant Staphylococcus aureus biofilms

Frontiers in Microbiology, 2022
Growing evidence has shown that the efficacy of systemic administration of daptomycin for the treatment of methicillin-resistant Staphylococcus aureus (MRSA)-related infections is satisfactory.
Xin Zhang, Xin Zhang, Peng Chen, Peng Chen, Hao-yang Wan, Run-jiu Zhu, Yue Zhou, Ming-rui Song, Nan Jiang, Nan Jiang, Bin Yu, Bin Yu   +11 more
doaj   +1 more source

The Potential Role of Sulbactam and Cephalosporins Plus Daptomycin Against Daptomycin-Nonsusceptible VISA and H-VISA Isolates: An In Vitro Study

Antibiotics, 2019
This study assesses the synergistic effect of the combination of cephalosporins and sulbactam with daptomycin against daptomycin-nonsusceptible, vancomycin-intermediate resistant Staphylococcus aureus (VISA) or heterogeneous vancomycin-intermediate S ...
Chih-Cheng Lai, Chi-Chung Chen, Ying-Chen Lu, Tsuey-Pin Lin, Hung-Jui Chen, Bo-An Su, Chien-Ming Chao, Yin-Ching Chuang, Hung-Jen Tang   +8 more
doaj   +1 more source

Brazilian experience in EU-CORE: daptomycin registry and treatment of serious Gram-positive infections

Brazilian Journal of Infectious Diseases, 2013
Objectives: To collect data about non-controlled prescribing use of daptomycin and its impact among Brazilian patients with serious Gram positive bacterial infection, as well as the efficacy and safety outcomes.
Artur Timerman, Carlos Brites, Eliana Bicudo, Renato S. Grinbaum, Rubens Costa Filho, Claudia D.M. Carrilho, Andre Bichels, Tânia Barreto   +7 more
doaj   +3 more sources

Optimizing Daptomycin Dosing: Environmental Benefit and Cost Savings

Antimicrobial Stewardship & Healthcare Epidemiology
Background: The pharmaceutical industry is estimated to have a larger environmental footprint than the automotive industry. Discarded and unused doses of pharmaceuticals generate financial waste and pollution, and exacerbate antibiotic shortages.
Pamela Lee, Marina Nguyen, Michelle LeBrun, Gary Fong, Loren Miller   +4 more
doaj   +1 more source