Results 31 to 40 of about 148 (100)

Diarylpyrimidine−Dihydrobenzyloxopyrimidine Hybrids: New, Wide-Spectrum Anti-HIV-1 Agents Active at (Sub)-Nanomolar Level

, 2016
Here, we describe a novel small series of non-nucleoside reverse transcriptase inhibitors (NNRTIs) that combine peculiar structural features of diarylpyrimidines (DAPYs) and dihydro-alkoxy-benzyl-oxopyrimidines (DABOs).
Maxim B. Nawrozkij (2204731), Bonaventura Clotet (91238), José A. Esté (1705729), Giovanni Maga (10904), Domenico Tarantino (561187), Alberta Samuele (2060419), Dante Rotili (462382), Marino Artico (2093173), Emmanuel Gonzalez-Ortega (2204734), Antonello Mai (205768)   +9 more
core   +1 more source

Diarylpyrimidine-Dihydrobenzyloxopyrimidine Hybrids: New, Wide-Spectrum Anti-HIV-1 Agents Active at (Sub)-Nanomolar Level.

, 2011
Here, we describe a novel small series of nonnucleoside reverse transcriptase inhibitors (NNRTIs) that combine peculiar structural features of diarylpyrimidines (DAPYs) and dihydro-alkoxy-benzyl-oxopyrimidines (DABOs).
NAWROZKIJ MB, SAMUELE A, TARANTINO D, ESTE, JA, GONZALEZ ORTEGA E, CLOTET B, ROTILI, Dante, ARTICO M, MAI, Antonello, MAGA G, Alberta Samuele, Dante Rotili, Antonello Mai, Domenico Tarantino, Emmanuel Gonzalez-Ortega, Marino Artico, Giovanni Maga, José A. Esté, Maxim B. Nawrozkij, Bonaventura Clotet, GonzalezOrtega E, Rotili D, Estee JA, Mai A   +23 more
core   +1 more source

Diarylpyrimidine-dihydrobenzyloxopyrimidine hybrids: New, wide-spectrum anti-HIV-1 agents active at (Sub)-nanomolar level

, 2021
Here, we describe a novel small series of non-nucleoside reverse transcriptase inhibitors (NNRTIs) that combine peculiar structural features of diarylpyrimidines (DAPYs) and dihydro-alkoxy-benzyl-oxopyrimidines (DABOs).
Rotili D.
core  

Rational Approaches for the Design of Effective Human Immunodeficiency Virus Type 1 Nonnucleoside Reverse Transcriptase Inhibitors [PDF]

, 2010
The binding of several classes of nonnucleoside reverse transcriptase inhibitors (NNRTIs) to wild-type (wtRT) and K103N mutant (mRT) human immunodeficiency virus type 1 (HIV-1) reverse transcriptase is studied by molecular dynamics and energy ...
Margarita C. Briñón, Ribone, Sergio Roman, Sergio R. Ribone, Madrid, Marcela, Quevedo, Mario Alfredo, Mario A. Quevedo, Briñon, Margarita Cristina, Marcela Madrid   +7 more
core   +1 more source

Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel"

, 2018
A new series of diarylpyrimidines (DAPYs) were designed, synthesized and evaluated as novel HIV-1 NNRTIs to further explore the chemical space surrounding the "hydrophobic channel" of the NNRTI binding pocket (NNIBP), guided by the comprehensive analysis
Zhan, Peng, De Clercq, Erik, Pannecouque, Christophe, Christophe Pannecouque, Daelemans, Dirk, Tao Liu, Kang, Dongwei, Wu, Gaochan, Gaochan Wu, Erik De Clercq, Huo, Zhipeng, Dirk Daelemans, Xinyong Liu, Zhongxia Zhou, Zhou, Zhongxia, Peng Zhan, Liu, Xinyong, Liu, Tao, Zhipeng Huo, Dongwei Kang   +19 more
core   +1 more source

Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV

, 2010
A series of novel diarylpyrimidine analogues featuring a hydroxyiminomethyl group between the pyrimidine scaffold and the aryl wing I have been synthesized and tested in MT-4 cells culture as non-nucleoside reverse transcriptase inhibitors against human ...
Pannecouque, Christophe, De Clercq, Erik, Chen, Fen-Er, Feng, Xiao-Qing, Zeng, Zhao-Sen, Balzarini, Jan, Liang, Yong-Hong, Christophe Pannecouque, Zhao-Sen Zeng, Yong-Hong Liang, Jan Balzarini, Xiao-Qing Feng, Erik De Clercq, Fen-Er Chen   +13 more
core   +1 more source

Rational Approaches for the Design of Effective Human Immunodeficiency Virus Type 1 Nonnucleoside Reverse Transcriptase Inhibitors

, 2016
The binding of several classes of nonnucleoside reverse transcriptase inhibitors (NNRTIs) to wild-type (wtRT) and K103N mutant (mRT) human immunodeficiency virus type 1 (HIV-1) reverse transcriptase is studied by molecular dynamics and energy ...
Sergio R. Ribone (2236228), Marcela Madrid (2076811), Mario A. Quevedo (2004565), Margarita C. Briñón (2236231)   +3 more
core   +1 more source

Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1

, 2018
A novel series of diarylpyrimidine (DAPY) derivatives bearing the biphenyl motif with multiple substituted groups was synthesized as human immunodeficiency virus (HIV)-1 non-nucleoside reverse transcriptase inhibitors.
KaiJun Jin, Erik De Clercq, Jin, KaiJun, De Clercq, Erik, Pannecouque, Christophe, Chen, FenEr, Christophe Pannecouque, Hong Yin, Meng, Ge, Ge Meng, Yin, Hong, FenEr Chen   +11 more
core   +1 more source

Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives as potent HIV-1 NNRTIs

, 2017
As a continuation of our efforts to discover and develop "me-better" drugs of DAPYs, novel diarylpyridine derivatives were designed, synthesized and evaluated for their anti-HIV activities in MT-4 cells.
Zhan, Peng, De Clercq, Erik, Pannecouque, Christophe, Christophe Pannecouque, Daelemans, Dirk, Liu, Zhaoqiang, Zhaoqiang Liu, Kang, Dongwei, Boshi Huang, Liu, Jinghan, Erik De Clercq, Huang, Boshi, Jinghan Liu, Dirk Daelemans, Xinyong Liu, Ye Tian, Peng Zhan, Tian, Ye, Liu, Xinyong, Dongwei Kang   +19 more
core   +1 more source

Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors

, 2013
This paper reports the synthesis and antiviral evaluation of a series of non-nucleoside reverse transcriptase inhibitors (NNRTIs) that combine the peculiar structural features of diarylpyrimidine derivatives (DAPYs) and benzophenone derivatives (BPs ...
Pannecouque, Christophe, Ma, Xiao-Dong, De Clercq, Erik, Daelemans, Dirk, Chen, Fen-Er, Yang, Shiqiong, Liu, Yang   +6 more
core   +1 more source