Results 1 to 10 of about 23,536 (264)
Viruses, 2014 Low-frequency HIV variants possessing resistance mutations against non‑nucleoside reverse transcriptase inhibitors (NNRTI), especially at HIV reverse transcriptase (RT) amino acid (aa) positions K103 and Y181, have been shown to adversely affect ...
Max Lataillade +2 more
exaly +5 more sources
Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the “NNRTI Adjacent” Binding Site [PDF]
ACS Medicinal Chemistry Letters, 2018 A novel series of diarylpyrimidine derivatives, which could simultaneously occupy the classical NNRTIs binding pocket (NNIBP) and the newly reported "NNRTI Adjacent" binding site, were designed, synthesized, and evaluated for their antiviral activities in MT-4 cell cultures.
Zhao Wang, Zhongxia Zhou, Dirk Daelemans
exaly +4 more sources
Cost-effectiveness of early treatment with first-line NNRTI-based HAART regimens in the UK, 1996-2006. [PDF]
PLoS ONE, 2011 Calculate time to first-line treatment failure, annual cost and cost-effectiveness of NNRTI versus PIboosted first-line HAART regimens in the UK, 1996-2006.Population costs for HIV services are increasing in the UK and interventions need to be effective ...
Eduard J Beck +19 more
doaj +3 more sources
Predictors of Liver Steatosis Progression Among People Living With HIV in Low- and Middle-Income Countries: A Multicentre Longitudinal Study. [PDF]
J Int AIDS SocABSTRACT Introduction Liver steatosis is increasingly recognized as a major comorbidity in people living with HIV (PLWH), with growing evidence suggesting an increased risk of progression to advanced liver disease. We assessed predictors of liver steatosis progression over 36 months in PLWH from low‐ and middle‐income countries.
Plaisy MK +27 more
europepmc +2 more sources
Журнал инфектологии, 2021 The aim of the study: to analyze the prevalence of resistance mutations to elsulfavirine and to evaluate the effectiveness of it among HIV-infected treatment-naïve patients in real clinical practice.Materials and methods.
A. A. Kirichenko +8 more
doaj +1 more source
BMC Infectious Diseases, 2021 Introduction The rise of HIV-1 drug resistance to non-nucleoside reverse-transcriptase inhibitors (NNRTI) threatens antiretroviral therapy's long-term success (ART).
Julien Riou +6 more
doaj +1 more source
AIDS Research and Therapy, 2023 Background Doravirine has a unique resistance profile but how this profile might increase its usefulness beyond first-line therapy in persons with susceptible viruses has not been well studied.
Soo-Yon Rhee +5 more
doaj +1 more source
The structure of FIV reverse transcriptase and its implications for non-nucleoside inhibitor resistance. [PDF]
PLoS Pathogens, 2018 Reverse transcriptase (RT) is the target for the majority of anti-HIV-1 drugs. As with all anti-AIDS treatments, continued success of RT inhibitors is persistently disrupted by the occurrence of resistance mutations.
Meytal Galilee, Akram Alian
doaj +1 more source
Genetic mechanisms of resistance to NRTI and NNRTI [PDF]
HIV Clinical Trials, 2002 Resistance to nucleoside reverse transcriptase inhibitors (NRTIs) seems to develop following three different pathways. Discriminatory mutations favor the binding of physiologic nucleosides over that of drugs. The newly so-called nucleoside-associated mutations (NAMs) enhance the removal of chain terminators (pyrophosphorolysis) from the cDNA in ...
Vincent, Soriano, Carmen, de Mendoza
openaire +2 more sources
Impact of scaling up dolutegravir on antiretroviral resistance in South Africa: A modeling study.
PLoS Medicine, 2020 BackgroundRising resistance of HIV-1 to non-nucleoside reverse transcriptase inhibitors (NNRTIs) threatens the success of the global scale-up of antiretroviral therapy (ART).
Anthony Hauser +7 more
doaj +1 more source