Results 41 to 50 of about 23,536 (264)

Kaplan-Meier estimates of risk for NNRTI-related skin rash according to NNRTI used.

, 2014
Kaplan-Meier estimates of risk for NNRTI-related skin rash according to NNRTI used.
Fred Stephen Sarfo (139071), Betty Norman (550971), Richard Phillips (205457), Maame Anima Sarfo (550970), David Chadwick (300132)   +4 more
core   +1 more source

Rilpivirine and Doravirine have complementary efficacies against NNRTI-Resistant HIV-1 mutants

Journal of Acquired Immune Deficiency Syndromes, 2016
Background:Rilpivirine (RPV) is the latest non-nucleoside reverse transcriptase inhibitor (NNRTI) to be approved by Food and Drug Administration to combat HIV-1 infections.
Steven J. Smith, Gary T. Pauly, Aamir Akram, Kevin Melody, Zandrea Ambrose, J. Schneider, S. Hughes   +6 more
semanticscholar   +1 more source

NNRTI mutations.

, 2013
NNRTI mutations.
Nuala McGrath (230042), Tulio de Oliveira (68362), Kevindra K. Naidu (448603), Andrew Skingsley (448602), Richard J. Lessells (348714), Marie-Louise Newell (78337), Justen Manasa (349682)   +6 more
core   +1 more source

Interval between exposure to single-dose nevirapine and starting NNRTI-based antiretroviral therapy in the NNRTI Response Study—Zambia, Kenya, Thailand (2005 – 2008).

, 2013
Interval between exposure to single-dose nevirapine and starting NNRTI-based antiretroviral therapy in the NNRTI Response Study—Zambia, Kenya, Thailand (2005 – 2008).
Craig B. Borkowf (226185), Dorothy Mbori-Ngacha (219137), John Odero Ong'ech (367004), Isaac Zulu (95507), Marc Bulterys (226212), James Kiarie (172633), Michelle S. McConnell (339130), Sonal Pathak (207736), Nathan Shaffer (186979), Paul J. Weidle (226178), Dara Potter (364737), Tavatchai Jariyasethpong (367001), Bongkoch Jetsawang (367007), Lungowe Njobvu (367005), Jeffrey S. A. Stringer (109553), Omotayo Bolu (367000), Peter Muiruri (367003), Winnie Mutsotso (367002), Thanomsak Anekthananon (221605)   +18 more
core   +1 more source

2507. Transmitted and Acquired NNRTI Resistance in the Philippines: Are Newer Generation NNRTIs a Viable Option?

Open Forum Infectious Diseases, 2019
Abstract Background Doravirine, rilpivirine, and etravirine are newer generation non-nucleoside reverse transcriptase inhibitors (NNRTI) that are intended to be more durable alternatives to efavirenz and nevirapine.
Theresa Dungca, Nina, Schwem, Brian, Arevalo, Geraldine, Francisco, Christian, Penalosa-Ramos, Christine, Ching, Patrick, Leyritana, Katerina, Destura, Raul, Lim, Jodor, Tactacan-Abrenica, Rosario, Telan, Elizabeth, Solante, Rontgene, Samonte, Genesis, Trinidad, Lyka, Mendoza, Kevin, Alejandria, Marissa M, Salvana, Edsel Maurice T   +16 more
openaire   +1 more source

Conformational plasticity of the NNRTI-binding pocket in HIV-1 reverse transcriptase - A fluorine NMR study

Biochemistry, 2016
HIV-1 reverse transcriptase (RT) is a major drug target in the treatment of HIV-1 infection. RT inhibitors currently in use include non-nucleoside, allosteric RT inhibitors (NNRTIs), which bind to a hydrophobic pocket, distinct from enzyme's active site.
N. G. Sharaf, R. Ishima, A. Gronenborn
semanticscholar   +1 more source

NNRTI PDR trends in Nicaragua.

, 2016
PDR was estimated by year of enrolment using the HIVdb tool from Sanger sequences. Individuals with drug resistance were defined as those with at least low-level resistance (Stanford penalty score ≥15) to any NNRTI. A.
Daniela Tapia-Trejo (825189), Margarita Matías-Florentino (3219228), Carlos J. Quant-Durán (3219237), Santiago Avila-Ríos (3219234), Bismarck F. Hernández-Álvarez (3219222), Gustavo Reyes-Terán (115886), Claudia García-Morales (196309), Sumaya E. Moreira-López (3219231), Guillermo Porras-Cortés (3219225)   +8 more
core   +1 more source

Predictors of detection of NNRTI resistance-associated mutations (RAMs) after interruption of NNRTI-based ART.^a

, 2013
aDetection of NNRTI-RAMs by all testing modalities. NNRTI concentrations were analyzed in a separate model due to smaller numbers.bAs noted above some patients had the viral load measured by assays with a lower limit of quantification of either 75 or 400
Giota Touloumi (71587), Jeffrey A. Johnson (32526), Zoe Fox (434458), Lieven J. Stuyver (249761), Andrew Owen (355644), Clare Booth (255132), Clara Lehmann (364137), Jonathan Lipscomb (32529), John Baxter (231162), Andrew Phillips (201315), Gilda Tachedjian (37210), Anna Maria Geretti (434457)   +11 more
core   +1 more source

Pretreatment resistance mutations and treatment outcomes in adults living with HIV-1: a cohort study in urban Malawi

AIDS Research and Therapy, 2020
Background Pre-treatment drug resistance (PDR) among antiretroviral drug-naïve people living with HIV (PLHIV) represents an important indicator for the risk of treatment failure and the spread of drug resistant HIV variants. We assessed the prevalence of
F. Neuhann, A. de Forest, E. Heger, A. Nhlema, C. Scheller, R. Kaiser, H. M. Steffen, H. Tweya, G. Fätkenheuer, S. Phiri   +9 more
doaj   +1 more source

Evolution of primary HIV drug resistance in a subtype C dominated epidemic in Mozambique. [PDF]

PLoS ONE, 2013
In Mozambique, highly active antiretroviral treatment (HAART) was introduced in 2004 followed by decentralization and expansion, resulting in a more than 20-fold increase in coverage by 2009. Implementation of HIV drug resistance threshold surveys (HIVDR-
Dulce Celina Adolfo Bila, Peter Young, Harriet Merks, Adolfo Salvador Vubil, Mussagy Mahomed, Angelo Augusto, Celina Monteiro Abreu, Nédio Jonas Mabunda, James I Brooks, Amilcar Tanuri, Ilesh Vinodrai Jani   +10 more
doaj   +1 more source