Results 61 to 70 of about 23,536 (264)

Cardiometabolic Differences in People Living with HIV Receiving Integrase Strand Transfer Inhibitors Compared to Non-nucleoside Reverse Transcriptase Inhibitors: Implications for Current ART Strategies

Viruses
In people living with HIV (PLHIV), integrase strand transfer inhibitors (INSTIs) are part of the first-line combination antiretroviral therapy (cART), while non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens are alternatives.
Wilhelm A. J. W. Vos, Nadira Vadaq, Vasiliki Matzaraki, Twan Otten, Albert L. Groenendijk, Marc J. T. Blaauw, Louise E. van Eekeren, Kees Brinkman, Quirijn de Mast, Niels P. Riksen, Anton F. H. Stalenhoef, Jan van Lunzen, Andre J. A. M. van der Ven, Willem L. Blok, Janneke E. Stalenhoef   +14 more
doaj   +1 more source

Review The Emerging Profile of Cross-Resistance among the Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors

Viruses, 2014
Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are widely used to treat HIV-1-infected individuals; indeed most first-line antiretroviral therapies typically include one NNRTI in combination with two nucleoside analogs.
Nicolas Sluis-Cremer
doaj   +1 more source

Dietary counselling and exercise training for lipid management in people living with HIV: A systematic review and meta‐analysis

HIV Medicine, EarlyView.
Abstract Objectives Dyslipidaemia is highly prevalent among people living with human immunodeficiency virus (HIV) and contributes to increased cardiovascular risk. Although lifestyle interventions are recommended, evidence specific to people living with HIV remains limited. Previous reviews have primarily focused on dietary interventions or low‐density
Maki Aomori, Hitomi Maeda
wiley   +1 more source

Real‐world use and effectiveness of fostemsavir in a US clinical setting: Insights from Trio Health HIV Research Network

HIV Medicine, EarlyView.
Abstract Objective To describe real‐world patterns of use, virologic and immunologic outcomes and treatment persistence among people with HIV (PWH) initiating fostemsavir (FTR) in a diverse US cohort. Design Retrospective cohort study of adults receiving FTR in clinical practice, stratified by baseline viral suppression status.
Richard Elion, Cassidy Henegar, Isobel McEwen, Andrew Frick, Moti Ramgopal, Steven Santiago, Karam Mounzer, Gregory Huhn, Charles Walworth, Leigh Ragone, Vani Vannappagari   +10 more
wiley   +1 more source

Prevalence of major NRTI and NNRTI resistance mutations in individuals with acquired drug resistance.

, 2016
Absolute and cumulative prevalence of each major nucleoside (NRTI) and nonnucleoside RT inhibitor (NNRTI) drug-resistance mutation (DRM) in 4,926 individuals with virological failure and intermediate or high-level acquired NRTI or NNRTI resistance while ...
Neil Parkin (273844), Annemarie M. J. Wensing (105565), Rami Kantor (7863), Soo-Yon Rhee (42412), Elliot Raizes (840995), Mark A. Wainberg (196455), Irene Mukui (757883), Douglas D. Richman (168764), Mina C. Hosseinipour (143744), Jonathan M. Schapiro (374093), Joseph E. Fitzgibbon (840997), Marco Schito (840998), Carole L. Wallis (326872), Nicaise Ndembi (703630), Michael R. Jordan (146520), Raph L. Hamers (718072), Avelin F. Aghokeng (322582), Clement Zeh (226174), Gert U. Van Zyl (427181), Michele Tang (840996), Robert W. Shafer (32534), Tobias F. Rinke de Wit (178193), Joseph Fokam (322576), Lisa M. Frenkel (337077), Chunfu Yang (293864), Arlene Chua (134856), Joel E. Gallant (348304), David Katzenstein (182035), Silvia Bertagnolio (57174), Ravindra K. Gupta (372679), Tulio De Oliveira (5666317), Sergio Carmona (562195)   +31 more
core   +1 more source

Impact of V179D/E mutations on antiretroviral therapy outcomes in people living with HIV-1: a 3-year retrospective study

Frontiers in Cellular and Infection Microbiology
BackgroundHIV-1 mutation V179D/E can confer potential low-level resistance to multiple non-nucleoside reverse transcriptase inhibitors (NNRTIs), and its detection rate has increased in recent years.
Shiyun Lv, Shiyun Lv, Yun Lan, Yun Lan, Quanmin Li, Quanmin Li, Xuemei Ling, Xuemei Ling, Junbin Li, Junbin Li, Chunyan Wen, Chunyan Wen, Yonghong Li, Yonghong Li, Jingliang Chen, Jingliang Chen, Xiejie Chen, Xiejie Chen, Weiping Cai, Weiping Cai, Xiaoping Tang, Xiaoping Tang, Xiaoping Tang, Linghua Li, Linghua Li   +24 more
doaj   +1 more source

Incidence and determinants of nevirapine and efavirenz-related skin rashes in West Africans: nevirapine's epitaph?

PLoS ONE, 2014
Non-nucleoside reverse transcriptase inhibitor (NNRTI) associated rash is common and frequently leads to discontinuation of NNRTIs. This study assessed the risk of developing rashes and discontinuing NNRTIs and associated factors in a large clinic in ...
Fred Stephen Sarfo, Maame Anima Sarfo, Betty Norman, Richard Phillips, David Chadwick   +4 more
doaj   +1 more source

Cytotoxic T cell recognition of an HIV-1 reverse transcriptase variant peptide incorporating the K103N drug resistance mutation

AIDS Research and Therapy, 2006
During HIV-1 infection, cytotoxic T cell (CTL) responses exert strong selective pressure on the replicating virus population. Here we report evidence for T cell activity against the drug resistant K103N region of viral reverse transcriptase in three HIV ...
Clifford David, Mahnke Lisa
doaj   +1 more source

Stability of the HIV cascade of care throughout the COVID‐19 pandemic in Europe: Results from the multinational EuroSIDA cohort study (2016–2022)

HIV Medicine, EarlyView.
Abstract Background Prior to the COVID‐19 pandemic, antiretroviral therapy (ART) coverage and viral suppression were improving across Europe; however, the impact of the pandemic on HIV care remains uncertain. Methods In‐person visits, ART coverage and viral suppression among those on ART were described in the EuroSIDA cohort for each calendar year from
Olga Fursa, Wendy Bannister, Giovanni Guaraldi, Justyna Kowalska, Jose M. Miro, Robert Zangerle, David Jilich, Jean‐Paul Viard, Katharina Kusejko, Piotr Nowak, Pere Domingo, Claire Mackintosh, Antonella Castagna, Thomas Benfield, Bartosz Szetela, Johannes Bogner, Marta Boffito, Lars Peters, on behalf of the EuroSIDA study group   +18 more
wiley   +1 more source

Non-nucleoside reverse transcriptase inhibitors (NNRTI) mutation profiles.

, 2014
Profiles associated with failure to NNRTIs are depicted in white, profiles associated with failure to non-NNRTI regimens are depicted in grey. The numbers represent percentages.
Irene Ketseoglou (562194), Michelle Bronze (326869), Kim Steegen (326871), Leon Levin (562193), Maria A. Papathanasopoulos (326877), Sergio Carmona (562195), Wendy Stevens (62288)   +6 more
core   +1 more source