Results 31 to 40 of about 23,497 (215)

Treatment of Young Children with HIV Infection: Using Evidence to Inform Policymakers [PDF]

, 2012
PMCID: PMC3404108This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Abrams, EJ, Cotton, M, Gibb, DM, Mulenga, V, Musoke, P, Penazzato, M, Prendergast, AJ   +6 more
core   +3 more sources

Drug resistance and viral tropism in HIV-1 subtype C-infected patients in KwaZulu-Natal, South Africa: implications for future treatment options [PDF]

, 2011
Article approval pendingDrug resistance poses a significant challenge for the successful application of highly active antiretroviral therapy (HAART) globally. Furthermore, emergence of HIV-1 isolates that preferentially use CXCR4 as a coreceptor for cell
Ashika Singh, Bjorndal, Brenner, Briggs, Briz, Cann, Cecilia, Cilliers, Coakley, Coetzer, Connor, Cozzi-Lepri, Daniel R. Kuritzkes, Elizabeth D. Anton, Fouchier, Fouchier, Furtado, Henry Sunpath, Hosseinipour, Hunt, Irlbeck, Jacqueline D. Reeves, Johnston, Kantor, Keshni Hiramen, Kuiken, Loemba, Low, Marconi, Nagavelli Padayachi, Ndungu, Novitsky, Reeves, Richard Murphy, Rizzuto, Scarlatti, Singh, Tamura, Taryn N. Green, Taylor, Thumbi Ndung'u, Tobin, Trinh, Tscherning, Wallis, Westby, Whitcomb, Wu, Yolanda Lie   +48 more
core   +2 more sources

HIV-1 induces in vivo platelet activation by enhancing platelet NOX2 activity. [PDF]

, 2015
OBJECTIVES: HIV-1 patients show increased platelet activation, but the mechanisms involved are not completely clarified. We speculated that HIV-1 might induce in vivo platelet activation by enhancing platelet NOX2-related oxidative stress.
Bartimoccia, Simona, Carnevale, Roberto, Di Campli, Francesco, Esposito, Antonella, Fantauzzi, Alessandra, Mezzaroma, Ivano, Novo, Marta, Pastori, Daniele, Pignatelli, Pasquale, Violi, Francesco   +9 more
core   +1 more source

Long-lasting protection of activity of nucleoside reverse transcriptase inhibitors and protease inhibitors (PIs) by boosted PI containing regimens. [PDF]

PLoS ONE, 2012
BACKGROUND: The accumulation of mutations after long-lasting exposure to a failing combination antiretroviral therapy (cART) is problematic and severely reduces the options for further successful treatments.
Alexandra U Scherrer, Jürg Böni, Sabine Yerly, Thomas Klimkait, Vincent Aubert, Hansjakob Furrer, Alexandra Calmy, Matthias Cavassini, Luigia Elzi, Pietro L Vernazza, Enos Bernasconi, Bruno Ledergerber, Huldrych F Günthard, Swiss HIV Cohort Study (SHCS)   +13 more
doaj   +1 more source

Virologic failure and second-line antiretroviral therapy in children in South Africa--the IeDEA Southern Africa collaboration [PDF]

, 2011
Article approval pendingWith expanding pediatric antiretroviral therapy (ART) access, children will begin to experience treatment failure and require second-line therapy. We evaluated the probability and determinants of virologic failure and switching in
Boulle, Andrew, Davies, Mary-Ann, Egger, Matthias, Eley, Brian, Giddy, Janet, Keiser, Olivia, Moultrie, Harry, Rabie, Helena, Technau, Karl, Van Cutsem, Gilles, Wood, Robin   +10 more
core   +2 more sources

Rapid CD4 decline after interruption of non-nucleoside reverse transcriptase inhibitor-based antiretroviral therapy in a resource-limited setting

AIDS Research and Therapy, 2007
Background Non-nucleoside reverse transcriptase inhibitor (NNRTI) with stavudine and lamivudine is widely used as the first-line antiretroviral therapy (ART) in resource-limited settings.
Watcharananan Siriorn, Malathum Kumthorn, Apisarnthanarak Anucha, Kiertiburanakul Sasisopin, Sungkanuparph Somnuek, Sathapatayavongs Boonmee   +5 more
doaj   +1 more source

Optimization of diarylazines as anti-HIV agents with dramatically [PDF]

, 2013
Non-nucleoside inhibitors of HIV-1 reverse transcriptase are reported that have ca. 100-fold greater solubility than the structurally related drugs etravirine and rilpivirine, while retaining high anti-viral activity.
Anderson, Karen S., Bollini, Mariela, Cisneros, José A., Jorgensen, William L., Spasov, Krasimir A.   +4 more
core   +1 more source

Emergence of an NNRTI Resistance Mutation Y181C in an HIV-Infected NNRTI-Naive Patient

AIDS Research and Human Retroviruses, 2008
The purpose of our study was to examine the emergence of the Y181C resistance mutation in an NNRTI-naive subject (index patient) at different time points. Phylogenetic trees in protease (PR) and partial reverse transcriptase (RT) regions were inferred by the maximum likelihood (ML) method.
Magiorkinis, E., Paraskevis, D., Sambatakou, H., Gargalianos, P., Haida, C., Vassilakis, A., Hatzakis, A.   +6 more
openaire   +3 more sources

Nevirapine versus Efavirenz for patients co-infected with HIV and Tuberculosis: A Randomised Non-Inferiority Trial [PDF]

, 2013
BACKGROUND: In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antituberculosis drugs. We aimed to compare efficacy and safety of a nevirapine-
Agnès Sobry, Alexandra Calmy, Anne-Marie Taburet, Avihingsanon, Blackwelder, Boulle, Carlota Silva, Chen, Christine Rouzioux, Christophe Michon, Cohen, Cohen, Davies, Dejesus, Dieterich, Elisabeth Baudin, Elizabete Nunes, Flandre, Ford, Gengiah, Gulick, Ilesh Jani, Kwara, Laura Ciaffi, Maartens, Manosuthi, Manosuthi, Maryline Bonnet, Matteelli, Mbuagbaw, Meintjes, Nilesh Bhatt, Rui Bastos, Scourfield, Shipton, Soriano, Swaminathan, Tang, Telenti, van Leth   +39 more
core   +3 more sources

Bridging the gap between HIV epidemiology and antiretroviral resistance evolution: Modelling the spread of resistance in South Africa.

PLoS Computational Biology, 2019
The scale-up of antiretroviral therapy (ART) in South Africa substantially reduced AIDS-related deaths and new HIV infections. However, its success is threatened by the emergence of resistance to non-nucleoside reverse-transcriptase inhibitors (NNRTI ...
Anthony Hauser, Katharina Kusejko, Leigh F Johnson, Gilles Wandeler, Julien Riou, Fardo Goldstein, Matthias Egger, Roger D Kouyos   +7 more
doaj   +1 more source