Results 11 to 20 of about 23,536 (264)

NNRTI and Liver Damage: Evidence of Their Association and the Mechanisms Involved [PDF]

Cells, 2021
Due to the improved effectiveness and safety of combined antiretroviral therapy, human immunodeficiency virus (HIV) infection has become a manageable, chronic condition rather than a mortal disease. However, HIV patients are at increased risk of experiencing non-AIDS-defining illnesses, with liver-related injury standing out as one of the leading ...
Ana M. Benedicto, Isabel Fuster-Martínez, Joan Tosca, Juan V. Esplugues, Ana Blas-García, Nadezda Apostolova   +5 more
openaire   +6 more sources

The rate of accumulation of nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance in patients kept on a virologically failing regimen containing an NNRTI^* [PDF]

HIV Medicine, 2011
BackgroundVirological failure of first‐generation nonnucleoside reverse transcriptase inhibitors (NNRTIs) can compromise the efficacy of etravirine as a result of the accumulation of NNRTI resistance mutations. How quickly NNRTI resistance accumulates in patients with a delayed switch from nevirapine or efavirenz despite virological failure, when these
Cozzi lepri, A., Paredes, R., Phillips, A. N., Clotet, B., Kjã¦r, J., Von Wyl, V., Kronborg, G., CASTAGNA, ANTONELLA, Bogner, J. R., Lundgren, J. D.   +9 more
openaire   +6 more sources

Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case–control study using centralized ultrasensitive 454 pyrosequencing [PDF]

Journal of Antimicrobial Chemotherapy, 2014
Objectives It is still debated if pre-existing minority drug-resistant HIV-1 variants (MVs) affect the virological outcomes of first-line NNRTI-containing ART.
A. Cozzi-Lepri, M. Noguera-Julián, F. Di Giallonardo, R. Schuurman, M. Däumer, S. Aitken, F. Ceccherini-Silberstein, Antonella d'Arminio Monforte, A. Geretti, C. Booth, R. Kaiser, C. Michalik, K. Jansen, B. Masquelier, P. Bellecave, R. Kouyos, E. Castro, H. Furrer, A. Schultze, H. Günthard, F. Brun-Vézinet, R. Paredes, K. Metzner   +22 more
semanticscholar   +3 more sources

NNRTI-induced HIV-1 protease-mediated cytotoxicity induces rapid death of CD4 T cells during productive infection and latency reversal

Retrovirology, 2019
Background Current efforts towards HIV-1 eradication focus on the reactivation and elimination of the latent viral reservoir, so-called shock and kill therapy.
Benjamin Trinité, Hongtao Zhang, David N. Levy   +2 more
doaj   +2 more sources

Connection Subdomain Mutations in HIV-1 Subtype-C Treatment-Experienced Patients Enhance NRTI and NNRTI Drug Resistance [PDF]

Virology, 2012
Mutations in the connection subdomain (CN) and RNase H domain (RH) of HIV-1 reverse transcriptase (RT) from subtype B-infected patients enhance nucleoside and nonnucleoside RT inhibitor (NRTI and NNRTI) resistance by affecting the balance between ...
Krista A. Delviks-Frankenberry, Renan B Lengruber, André F. A. Santos, J. Silveira, M. Soares, M. Kearney, F. Maldarelli, V. Pathak   +7 more
semanticscholar   +2 more sources

Virtual screening, molecular docking studies and DFT calculations of FDA approved compounds similar to the non-nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz

Heliyon, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed as the causative virus of COVID-19 disease, which is currently a worldwide pandemic. Efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI), is one of the most potent
M. A. Jordaan, Oluwakemi Ebenezer, Nkululeko E. Damoyi, M. Shapi   +3 more
semanticscholar   +1 more source

Pre-treatment HIV-drug resistance associated with virologic outcome of first-line NNRTI-antiretroviral therapy: A cohort study in Kenya

EClinicalMedicine, 2020
Background Pre-treatment HIV-drug-resistance (PDR) to WHO-recommended 1st-line non-nucleoside reverse transcriptase inhibitors (NNRTI)-based antiretroviral treatment (ART) is increasing in low-resource communities.
I. Beck, Molly Levine, Christine J. McGrath, Steve Bii, Ross S. Milne, J. Kingoo, Isaac D. So, N. Andersen, S. Dross, R. Coombs, J. Kiarie, B. Chohan, S. Sakr, M. Chung, L. Frenkel   +14 more
semanticscholar   +1 more source

Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties.

European journal of medicinal chemistry, 2020
To yield potent HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with favorable drug-like properties, a series of novel diarylpyrimidine derivatives targeting the tolerant region I of the NNRTI binding pocket were designed, synthesized and ...
Xiang-Yi Jiang, Bo-Shi Huang, F. Olotu, Jing Li, Dong-Wei Kang, Zhao Wang, E. De Clercq, M. Soliman, C. Pannecouque, Xin-Yong Liu, Peng Zhan   +10 more
semanticscholar   +1 more source

Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root

European journal of medicinal chemistry, 2020
From an aqueous decoction of the traditional Chinese medicine “ban lan gen” (the Isatis indigotica root), an antiviral natural product CI - 39 was isolated as an NNRTI (non-nucleoside reverse transcriptase inhibitor) (EC50 = 3.40 μM). Its novel structure
Cheng-Bo Xu, Yi-Jing Xin, Minghua Chen, Ming-Yu Ba, Qing-lan Guo, Cheng-gen Zhu, Ying Guo, Jian-Gong Shi   +7 more
semanticscholar   +1 more source

Bone mineral density, kidney function, weight gain and insulin resistance in women who switch from TDF/FTC/NNRTI to ABC/3TC/DTG

HIV Medicine, 2020
Tenofovir disoproxil fumarate (TDF) is associated with reduced bone mineral density (BMD). We evaluated changes in BMD in women who switched from TDF, emtricitabine and a nonnucleoside reverse transcriptase inhibitor (TDF/FTC/NNRTI) to abacavir ...
F. Ibrahim, A. Samarawickrama, L. Hamzah, R. Vincent, Y. Gilleece, L. Waters, S. Kegg, B. Barbini, L. Campbell, Frank A. Post   +9 more
semanticscholar   +1 more source