Results 91 to 100 of about 2,442,143 (290)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Influence of displacement damage dose on dark current distributions of irradiated CMOS image sensors [PDF]
Dark current increase distributions due to displacement damages are modeled using displacement damage dose concept. Several CMOS image sensors have been exposed to neutrons or protons and we have characterized their degradation in terms of dark current ...
Bardoux, Alain +7 more
core
Direct Detection of sub-GeV Dark Matter with Semiconductor Targets
, 2016 Dark matter in the sub-GeV mass range is a theoretically motivated but largely unexplored paradigm. Such light masses are out of reach for conventional nuclear recoil direct detection experiments, but may be detected through the small ionization signals ...
Essig, Rouven +5 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Practical True Random Number Generator Using CMOS Image Sensor Dark Noise
IEEE Access, 2019 We present a true random number generator (TRNG) using dark noise of a CMOS image sensor. Because the proposed TRNG is based on the dark characteristics of the CMOS image sensor, it does not require any additional hardware, such as light source and ...
Byung Kwon Park +7 more
doaj +1 more source
Dark current behavior in DSLR cameras
SPIE Proceedings, 2009 Digital single-lens reflex (DSLR) cameras are examined and their dark current behavior is presented. We examine the influence of varying temperature, exposure time, and gain setting on dark current. Dark current behavior unique to sensors within such cameras is observed.
Dunlap, Justin Charles +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Effect of Structural Defects on Parameters of Silicon Four-Quadrant p-i-n Photodiodes
East European Journal of PhysicsThe article examines the influence of structural defects, in particular dislocations, on the electrical and photovoltaic properties of silicon four-quadrant p-i-n photodiodes.
Mykola S. Kukurudziak
doaj +1 more source
Halo Mass Functions in Early Dark Energy Cosmologies
, 2008 We examine the linear density contrast at collapse time, $\delta_c$ for large-scale structure in dynamical dark energy cosmologies, including models with early dark energy.
Bartelmann +29 more
core +1 more source