Results 91 to 100 of about 801,069 (309)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Characterization of a Field Spectroradiometer for Unattended Vegetation Monitoring. Key Sensor Models and Impacts on Reflectance

Sensors, 2015
Field spectroradiometers integrated in automated systems at Eddy Covariance (EC) sites are a powerful tool for monitoring and upscaling vegetation physiology and carbon and water fluxes.
Javier Pacheco-Labrador, M. Pilar Martín   +1 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Sensitive parameters affecting dark current characteristics of SCD

, 2021
The sensitive parameters affecting the dark current characteristics are further studied by using InAs/GaSb type II superlattice (T2SL) pBpp structure long wavelength Infrared photodetectors.
Sun, Tong, Xiao, Wenliang, Wang, Shu Min, Liang, D., Han, Lihong, Lu, P. F., Ma, Xiaoguang, Song, Haizhi, Sun, Yifan   +8 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Effect of Structural Defects on Parameters of Silicon Four-Quadrant p-i-n Photodiodes

East European Journal of Physics
The article examines the influence of structural defects, in particular dislocations, on the electrical and photovoltaic properties of silicon four-quadrant p-i-n photodiodes.
Mykola S. Kukurudziak
doaj   +1 more source

Practical True Random Number Generator Using CMOS Image Sensor Dark Noise

IEEE Access, 2019
We present a true random number generator (TRNG) using dark noise of a CMOS image sensor. Because the proposed TRNG is based on the dark characteristics of the CMOS image sensor, it does not require any additional hardware, such as light source and ...
Byung Kwon Park, Hojoong Park, Yong-Su Kim, Ju-Sung Kang, Yongjin Yeom, Changhui Ye, Sung Moon, Sang-Wook Han   +7 more
doaj   +1 more source

CREATING A NEW SHORT MEASURE OF THE DARK TETRAD

, 2021
The four dark personality traits of Machiavellianism, psychopathy, narcissism, and sadism have been studied together under an overarching construct called the Dark Tetrad.
Dean, Sarah Frances
core