Results 71 to 80 of about 1,836,799 (336)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Quantum Haplodynamics, Dark Matter, and Dark Energy
Advances in High Energy Physics, 2014 In quantum haplodynamics (QHD) the weak bosons, quarks, and leptons are bound states of fundamental constituents, denoted as haplons. The confinement scale of the associated gauge group SU(2)h is of the order of Λh≃0.3 TeV.
Harald Fritzsch, Joan Solà
doaj +1 more source
Changes in Microbial Energy Metabolism Measured by Nanocalorimetry during Growth Phase Transitions
Frontiers in Microbiology, 2018 Calorimetric measurements of the change in heat due to microbial metabolic activity convey information about the kinetics, as well as the thermodynamics, of all chemical reactions taking place in a cell.
Alberto Robador +11 more
doaj +1 more source
The Growth of Structure in Interacting Dark Energy Models [PDF]
, 2009 If dark energy interacts with dark matter, there is a change in the background evolution of the universe, since the dark matter density no longer evolves as a^{-3}. In addition, the non-gravitational interaction affects the growth of structure.
Caldera-Cabral, Gabriela +2 more
core +2 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Weak lensing, dark matter and dark energy
, 2010 Weak gravitational lensing is rapidly becoming one of the principal probes of dark matter and dark energy in the universe. In this brief review we outline how weak lensing helps determine the structure of dark matter halos, measure the expansion rate of ...
A. Amara +123 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Dark Matter and Dark Energy in the Universe
Bibechana, 2014 Cosmological and astronomical observations predict that the present Universe is passing through an accelerating phase of expansion. The Universe emerged out of an exponential phase in the very early Universe.
BC Paul
doaj +3 more sources
Dark Energy - Dark Matter Unification: Generalized Chaplygin Gas Model
, 2005 We review the main features of the generalized Chaplygin gas (GCG) proposal for unification of dark energy and dark matter and discuss how it admits an unique decomposition into dark energy and dark matter components once phantom-like dark energy is ...
Bertolami, Orfeu
core +1 more source