Results 81 to 90 of about 1,836,799 (336)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Dark group: dark energy and dark matter [PDF]

Physics Letters B, 2004
We study the possibility that a dark group, a gauge group with particles interacting with the standard model particles only via gravity, is responsible for containing the dark energy and dark matter required by present day observations. We show that it is indeed possible and we determine the constrains for the dark group.
openaire   +2 more sources

Demonstration of scissor-cross ionization injection in laser wakefield accelerators

Communications Physics
Laser wakefield acceleration (LWFA) holds great potential in the exploration of the next-generation accelerators and future colliders, in which the injection mechanism plays a crucial role as it directly affects the characteristics of electron ...
Siyu Chen, Guangwei Lu, Xichen Hu, Mingyang Zhu, Minghao Ma, Ming Zeng, Hao Xu, Jia Wang, Mingxuan Wei, Jiao Jia, Zhida Yang, Hanmi Mou, Zhuofan Zhang, Runze Li, Feng liu, Boyuan Li, Min chen, Dazhang Li, Wenchao Yan   +18 more
doaj   +1 more source

Constraints on the Coupling between Dark Energy and Dark Matter from CMB data

, 2016
We investigate a phenomenological non-gravitational coupling between dark energy and dark matter, where the interaction in the dark sector is parameterized as an energy transfer either from dark matter to dark energy or the opposite.
Fornengo, Nicolao, Gariazzo, Stefano, Murgia, Riccardo   +2 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

DARK ENERGY, DARK MATTER AND GRAVITY [PDF]

International Journal of Modern Physics D, 2007
We discuss the motivation for high accuracy relativistic gravitational experiments in the solar system and complementary cosmological tests. We focus our attention on the issue of distinguishing a generic scalar theory of gravity as the underlying physical theory from the usual general-relativistic picture, where one expects the presence of ...
openaire   +2 more sources

From Dark Energy & Dark Matter to Dark Metric [PDF]

Foundations of Physics, 2009
It is nowadays clear that General Relativity cannot be the definitive theory of Gravitation due to several shortcomings that come out both from theoretical and experimental viewpoints. At large scales (astrophysical and cosmological) the attempts to match it with the latest observational data lead to invoke Dark Energy and Dark Matter as the bulk ...
CAPOZZIELLO, SALVATORE, M. De Laurentis, M. Francaviglia, S. Mercadante   +3 more
openaire   +4 more sources

Why we need to see the dark matter to understand the dark energy

, 2007
The cosmological concordance model contains two separate constituents which interact only gravitationally with themselves and everything else, the dark matter and the dark energy.
Hu W, Kunz M, M Kunz, Perlmutter S, Riess A, Spergel D N, Zwicky F   +6 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Dark Energy Survey: more than dark energy – an overview [PDF]

Monthly Notices of the Royal Astronomical Society, 2016
32 pages, 15 figures; a revised Figure 1 and minor changes, to match the published MNRAS ...
Dark Energy Survey Collaboration, Abbott, T., Abdalla, F. B., Aleksic, J., Allam, S., Amara, A., Bacon, D., Balbinot, E., Banerji, M., Bechtol, K., Benoit-Levy, A., Bernstein, G. M., Bertin, E., Blazek, J., Bonnett, C., Bridle, S., Brooks, D., Brunner, R. J., Buckley-Geer, E., Burke, D. L., Caminha, G. B., Capozzi, D., Carlsen, J., Carnero-Rosell, A., Carollo, M., Carrasco-Kind, M., Carretero, J., Castander, F. J., Clerkin, L., Collett, T., Conselice, C., Crocce, M., Cunha, C. E., D'Andrea, C. B., da Costa, L. N., Davis, T. M., Desai, S., Diehl, H. T., Dietrich, J. P., Dodelson, S., Doel, P., Drlica-Wagner, A., Estrada, J., Etherington, J., Evrard, A. E., Fabbri, J., Finley, D. A., Flaugher, B., Foley, R. J., Rosalba, P., Frieman, J., Garcia-Bellido, J., Gaztanaga, E., Gerdes, D. W., Giannantonio, T., Goldstein, D. A., Gruen, D., Gruendl, R. A., Guarnieri, P., Gutierrez, G., Hartley, W., Honscheid, K., Jain, B., James, D. J., Jeltema, T., Jouvel, S., Kessler, R., King, A., Kirk, D., Kron, R., Kuehn, K., Kuropatkin, N., Lahav, O., Li, T. S., Lima, M., Lin, H., Maia, M. A. G., Makler, M., Manera, M., Maraston, C., Marshall, J. L., Martini, P., McMahon, R. G., Melchior, P., Merson, A., Miller, C. J., Miquel, R., Mohr, J. J., Morice-Atkinson, X., Naidoo, K., Neilsen, E., Nichol, R. C., Nord, B., Ogando, R., Ostrovski, F., Palmese, A., Papadopoulos, A., Peiris, H., Peoples, J., Percival, W. J., Plazas, A. A., Reed, S. L., Refregier, A., Romer, A. K., Roodman, A., Ross, A., Rozo, E., Rykoff, E. S., Sadeh, I., Sako, M., Sanchez, C., Sanchez, E., Santiago, B., Scarpine, V., Schubnell, M., Sevilla-Noarbe, I., Sheldon, E., Smith, M., Smith, R. C., Soares-Santos, M., Sobreira, F., Soumagnac, M., Suchyta, E., Sullivan, M., Swanson, M., Tarle, G., Thaler, J., Thomas, D., Thomas, R. C., Tucker, D., Vieira, J. D., Vikram, V., Walker, A. R., Wechsler, R. H., Weller, J., Wester, W., Whiteway, L., Wilcox, H., Yanny, B., Zhang, Y., Zuntz, J.   +140 more
openaire   +9 more sources