Results 51 to 60 of about 1,030,126 (198)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Forecasting dark showers at Belle II

Journal of High Energy Physics, 2022
Dark showers from strongly interacting dark sectors that confine at the GeV scale can give rise to novel signatures at e + e − colliders. In this work, we study the sensitivity of B factory experiments to dark showers produced through an effective ...
Elias Bernreuther, Kai Böse, Torben Ferber, Christopher Hearty, Felix Kahlhoefer, Alessandro Morandini, Kai Schmidt-Hoberg   +6 more
doaj   +1 more source

Scalar dark matter behind b → sμμ anomaly

Journal of High Energy Physics, 2019
We construct a scalar dark matter model with U 1 L μ − L τ $$ \mathrm{U}{(1)}_{L_{\mu }-{L}_{\tau }} $$ symmetry in which the dark matter interacts with the quark flavours, allowing lepton non-universal b → s ℓ ℓ ¯ $$ s\ell \overline{\ell} $$ decays. The
Seungwon Baek
doaj   +1 more source

Dark matter searches and energy accumulation and release in materials

SciPost Physics Proceedings, 2023
Efforts to identify dark matter by detecting nuclear recoils produced by dark matter particles reveal low-energy backgrounds of unknown origin in different types of detectors.
Sergey Pereverzev
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Spectroscopic Needs for Imaging Dark Energy Experiments: Photometric Redshift Training and Calibration

, 2013
Large sets of objects with spectroscopic redshift measurements will be needed for imaging dark energy experiments to achieve their full potential, serving two goals:_training_, i.e., the use of objects with known redshift to develop and optimize photometric redshift algorithms; and_calibration_, i.e., the characterization of moments of redshift (or ...
Newman, J., Abate, A., Abdalla, F., Allam, S., Allen, S., Ansari, R., Bailey, S., Barkhouse, W., Beers, T., Blanton, M., Brodwin, M., Brownstein, J., Brunner, R., Carrasco-Kind, M., Cervantes-Cota, J., Chisari, E., Colless, M., Comparat, J., Coupon, J., Cheu, E., Cunha, C., de la Macorra, A., Dell'Antonio, I., Frye, B., Gawiser, E., Gehrels, N., Grady, K., Hagen, A., Hall, P., Hearin, A., Hildebrandt, H., Hirata, C., Ho, S., Honscheid, K., Huterer, D., Ivezic, Z., Kneib, J. -P., Kruk, J., Lahav, O., Mandelbaum, R., Marshall, J., Matthews, D., Ménard, B., Miquel, R., Moniez, M., Moos, W., Moustakas, J., Papovich, C., Peacock, J., Park, C., Rhodes, J., Ricol, J-S., Sadeh, I., Slozar, A., Schmidt, S., Stern, D., Tyson, T., von der Linden, A., Wechsler, R., Wood-Vasey, W., Zentner, A.   +60 more
openaire   +3 more sources

New constraints on coupled dark energy from the Planck satellite experiment [PDF]

Physical Review D, 2013
We present new constraints on coupled dark energy from the recent measurements of the cosmic microwave background anisotropies from the Planck satellite mission. We found that a coupled dark energy model is fully compatible with the Planck measurements, deriving a weak bound on the dark matter-dark energy coupling parameter xi = -0.49(-0.31)(+0.19) at ...
Salvatelli, V., Marchini, A, Lopez Honorez, Laura, Mena, Olga   +3 more
openaire   +4 more sources

Cosmic Acceleration, Dark Energy and Fundamental Physics

, 2007
A web of interlocking observations has established that the expansion of the Universe is speeding up and not slowing, revealing the presence of some form of repulsive gravity. Within the context of general relativity the cause of cosmic acceleration is a
Allen S. W., Astier P., Boughn S., Bousso R., Carroll S., Carroll S. M., Carroll S. M., Dvali G., Efstathiou G., Eisenstein D. J., Frieman J., Gunn J. E., Hu W., Hu W., Huterer D., Huterer D., Jarvis M., Knop R. A., Kolb E. W., Krauss L., Krauss L. M., Ostriker J. P., Perlmutter S., Perlmutter S., Petrosian V., Phillips M. M., Riess A., Riess A., Sahni V., Shapiro C., Spergel D., Spooner N. J. C., Tegmark M., Turner M. S., Turner M. S., Weinberg S.   +35 more
core   +1 more source

Fermionic singlet dark matter in one-loop solutions to the $$R_K$$ R K anomaly: a systematic study

European Physical Journal C: Particles and Fields, 2021
We study the dark matter phenomenology of Standard Model extensions addressing the reported anomaly in the $$R_K$$ R K observable at one-loop.
Mathias Becker, Dominik Döring, Siddhartha Karmakar, Heinrich Päs   +3 more
doaj   +1 more source

Addressing the Crisis in Fundamental Physics

, 2007
I present the case for fundamental physics experiments in space playing an important role in addressing the current "dark energy'' crisis. If cosmological observations continue to favor a value of the dark energy equation of state parameter w=-1, with no
CHRISTOPHER W. STUBBS, Miknaitis G.
core   +1 more source