Results 61 to 70 of about 685,566 (247)

Fermionic singlet dark matter in one-loop solutions to the $$R_K$$ R K anomaly: a systematic study

European Physical Journal C: Particles and Fields, 2021
We study the dark matter phenomenology of Standard Model extensions addressing the reported anomaly in the $$R_K$$ R K observable at one-loop.
Mathias Becker, Dominik Döring, Siddhartha Karmakar, Heinrich Päs   +3 more
doaj   +1 more source

Cosmic Acceleration, Dark Energy and Fundamental Physics

, 2007
A web of interlocking observations has established that the expansion of the Universe is speeding up and not slowing, revealing the presence of some form of repulsive gravity. Within the context of general relativity the cause of cosmic acceleration is a
Allen S. W., Astier P., Boughn S., Bousso R., Carroll S., Carroll S. M., Carroll S. M., Dvali G., Efstathiou G., Eisenstein D. J., Frieman J., Gunn J. E., Hu W., Hu W., Huterer D., Huterer D., Jarvis M., Knop R. A., Kolb E. W., Krauss L., Krauss L. M., Ostriker J. P., Perlmutter S., Perlmutter S., Petrosian V., Phillips M. M., Riess A., Riess A., Sahni V., Shapiro C., Spergel D., Spooner N. J. C., Tegmark M., Turner M. S., Turner M. S., Weinberg S.   +35 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

DaMaSCUS: The Impact of Underground Scatterings on Direct Detection of Light Dark Matter [PDF]

, 2017
Conventional dark matter direct detection experiments set stringent constraints on dark matter by looking for elastic scattering events between dark matter particles and nuclei in underground detectors.
Emken, Timon, Kouvaris, Chris
core   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Leptonic WIMP coannihilation and the current dark matter search strategy

Journal of High Energy Physics, 2018
We discuss the extent to which models of Weakly Interacting Massive Particle (WIMP) Dark Matter (DM) at and above the electroweak scale can be probed conclusively in future high energy and astroparticle physics experiments.
Michael J. Baker, Andrea Thamm
doaj   +1 more source

By Dawn's Early Light: CMB Polarization Impact on Cosmological Constraints

, 2012
Cosmic microwave background polarization encodes information not only on the early universe but also dark energy, neutrino mass, and gravity in the late universe through CMB lensing.
Das, Sudeep, Linder, Eric V.
core   +1 more source

Gravitational energy as dark energy: Towards concordance cosmology without Lambda [PDF]

, 2009
I briefly outline a new physical interpretation to the average cosmological parameters for an inhomogeneous universe with backreaction. The variance in local geometry and gravitational energy between ideal isotropic observers in bound structures and ...
Célérier, D.L. Wiltshire
core   +3 more sources

Optimizing New Dark Energy Experiments (Final Scientific Report) [PDF]

, 2012
This is the final scientific report for the University of Pittsburgh portion of the collaborative grant, 'Optimizing New Dark Energy Experiments'
openaire   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source