Results 101 to 110 of about 1,667,560 (344)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Macronova in GRB 050709 and the GRB-macronova connection

Nature Communications, 2016
A macronova is a clear signature that a short gamma-ray burst has been emitted by a compact-binary merger, but evidence of these events is so far scarce.
Zhi-Ping Jin, Kenta Hotokezaka, Xiang Li, Masaomi Tanaka, Paolo D’Avanzo, Yi-Zhong Fan, Stefano Covino, Da-Ming Wei, Tsvi Piran   +8 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Charmed baryon decays: SU(3) F breaking and CP violation

Journal of High Energy Physics
We present a comprehensive study of anti-triplet charmed baryon decays into octet baryons and pseudoscalar mesons using the SU(3) F flavor symmetry framework.
Chang Yang, Xiao-Gang He, Chia-Wei Liu
doaj   +1 more source

Constraints on the Coupling between Dark Energy and Dark Matter from CMB data

, 2016
We investigate a phenomenological non-gravitational coupling between dark energy and dark matter, where the interaction in the dark sector is parameterized as an energy transfer either from dark matter to dark energy or the opposite.
Fornengo, Nicolao, Gariazzo, Stefano, Murgia, Riccardo   +2 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The Sensitivity of HAWC to High-Mass Dark Matter Annihilations

, 2014
The High Altitude Water Cherenkov (HAWC) observatory is a wide field-of-view detector sensitive to gamma rays of 100 GeV to a few hundred TeV. Located in central Mexico at 19 degrees North latitude and 4100 m above sea level, HAWC will observe gamma rays
Abazajian, K. N., Abeysekara, A. U., Alfaro, R., Alvarez, C., Alvarez, J. D., Arceo, R., Arteaga-Velazquez, J. C., Barber, A. S., Baughman, B. M., Bautista-Elivar, N., Belmont, E., BenZvi, S. Y., Berley, D., Braun, J., Caballero-Lopez, R. A., Caballero-Mora, K. S., Carraminana, A., Castillo, M., Cotti, U., Cotzomi, J., de la Fuente, E., De Leon, C., DeYoung, T., Diaz-Cruz, L., Diaz-Velez, J. C., Dingus, B. L., DuVernois, M. A., E., S. F., Ellsworth, R. W., Fiorino, D. W., Fraija, N., Galindo, A., Garfias, F., Gonzalez, J. Becerra, Gonzalez, M. M., Goodman, J. A., Grabski, V., Gussert, M., Hampel-Arias, Z., Harding, J. P., Hernandez, R. Diaz, Huentemeyer, P., Hui, C. M., Imran, A., Iriarte, A., Karn, P., Kieda, D., Kunde, G. J., Lara, A., Lauer, R. J., Lee, W. H., Lennarz, D., Linares, E. C., Linnemann, J. T., Longo, M., Luna-Garcia, R., Marinelli, A., Martinez, H., Martinez, O., Martinez-Castro, J., Matthews, J. A. J., McEnery, J., Miranda-Romagnoli, P., Moreno, E., Mostafa, M., Nellen, L., Newbold, M., Noriega-Papaqui, R., Oceguera-Becerra, T., Patricelli, B., Pelayo, R., Perez-Perez, E. G., Pretz, J., Riviere, C., Rosa-Gonzalez, D., Rosales, M. Bonilla, Ryan, J., Salazar, H., Salesa, F., Sandoval, A., Schneider, M., Silich, S., Sinnis, G., Smith, A. J., Solares, H. A. Ayala, Springer, R. W., Taboada, I., Toale, P. A., Tollefson, K., Torres, E. Mendoza, Torres, I., Ukwatta, T. N., Vargas, H. Leon, Villasenor, L., Weisgarber, T., Westerhoff, S., Wisher, I. G., Wood, J., Woodle, K. Sparks, Yodh, G. B., Younk, P. W., Zaborov, D., Zepeda, A., Zhou, H.   +103 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Dark matter as dark energy

Physics Letters B, 2003
Velocity-dependent interactions in a fundamental-string dominated universe lead quite naturally, with reasonable assumptions on initial conditions, to an accelerating expanding universe without assuming the existence of a cosmological constant. This result also holds generically for a universe dominated by moving extremal black holes, owing to a ...
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source