Results 131 to 140 of about 1,660,126 (341)

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

First underground results with NEWAGE-0.3a direction-sensitive dark matter detector [PDF]

, 2010
K. Miuchi, H. Nishimura, K. Hattori, Naoki Higashi, Chihiro Ida, Satoshi Iwaki, S. Kabuki, H. Kubo, Shunsuke Kurosawa, K. Nakamura, Joseph Parker, Tatsuya Sawano, Michiaki Takahashi, T. Tanimori, Kojiro Taniue, K. Ueno, H. Sekiya, Atsushi Takeda, K. Tsuchiya, Atsushi Takada   +19 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Astrophysical Searches and Constraints on Ultralight Bosonic Dark Matter [PDF]

, 2021
David J. E. Marsh, Sebastian Hoof
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

The Carrier Wave Principle

International Journal of Communication, 2019
In this article, we propose a new theoretical premise called the “carrier wave principle.” It holds that there is no fixed limit to the amount and variety of knowledge that may be produced from a given cultural artifact.
Aram Sinnreich, Jesse Gilbert
doaj   +2 more sources

Recycled dark matter

Journal of Cosmology and Astroparticle Physics
Abstract We outline a new production mechanism for dark matter that we dub “recycling”: dark sector particles are kinematically trapped in the false vacuum during a dark phase transition; the false pockets collapse into primordial black holes (PBHs), which ultimately evaporate before Big Bang Nucleosynthesis (BBN) to reproduce the dark ...
Thomas C. Gehrman, Barmak Shams Es Haghi, Kuver Sinha, Tao Xu   +3 more
openaire   +2 more sources

Disk Galaxy Formation in a Λ Cold Dark Matter Universe [PDF]

, 2004
Brant Robertson, Naoki Yoshida, Volker Springel, Lars Hernquist   +3 more
openalex   +1 more source

Binary Collisions of Dark Matter Blobs [PDF]

, 2021
Melissa D. Diamond, David E. Kaplan, Surjeet Rajendran   +2 more
openalex   +1 more source