Results 71 to 80 of about 1,660,126 (341)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Unexpected major geomagnetic storm caused by faint eruption of a solar trans-equatorial flux rope

Nature Communications
Some geomagnetic storms’ solar origins are ambiguous, making them hard to predict. On March 23, 2023, a severe geomagnetic storm occurred, however, forecasts based on remote-sensing observations failed to predict it.
Weilin Teng, Yingna Su, Haisheng Ji, Qingmin Zhang   +3 more
doaj   +1 more source

Weak Gravitational Lensing as a Method to Constrain Unstable Dark Matter

, 2010
The nature of the dark matter remains a mystery. The possibility of an unstable dark matter particle decaying to invisible daughter particles has been explored many times in the past few decades.
Wang, Mei-Yu, Zentner, Andrew R.
core   +1 more source

Macro dark matter [PDF]

Monthly Notices of the Royal Astronomical Society, 2015
Dark matter is a vital component of the current best model of our universe, $ $CDM. There are leading candidates for what the dark matter could be (e.g. weakly-interacting massive particles, or axions), but no compelling observational or experimental evidence exists to support these particular candidates, nor any beyond-the-Standard-Model physics that
Jacobs, David M., Starkman, Glenn D., Lynn, Bryan W.   +2 more
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

A delayed 400 GeV photon from GRB 221009A and implication on the intergalactic magnetic field

Nature Communications
Large High Altitude Air Shower Observatory has detected 0.2 − 13 TeV emission of GRB 221009A within 2000 s since the trigger. Here we report the detection of a 400 GeV photon, without accompanying prominent low-energy emission, by Fermi Large Area ...
Zi-Qing Xia, Yun Wang, Qiang Yuan, Yi-Zhong Fan   +3 more
doaj   +1 more source

Resonant dark matter

Journal of High Energy Physics, 2009
It is usually assumed that dark matter direct detection is sensitive to a large fraction of the dark matter (DM) velocity distribution. We propose an alternative form of dark matter-nucleus scattering which only probes a narrow range of DM velocities due to the existence of a resonance, a DM-nucleus bound state, in the scattering - resonant dark matter
Bai, Yang, Fox, Patrick J.
openaire   +2 more sources

Supersymmetric dark matter [PDF]

Nuclear Physics B - Proceedings Supplements, 2002
After a short introduction on some general implications of recent cosmological observations, we discuss the properties of relic neutralinos in connection with present experimental strategies for detecting WIMPs.
BOTTINO, Alessandro, DONATO, Fiorenza, FORNENGO, Nicolao, S. Scopel   +3 more
openaire   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Classification of three-family flavoured DFSZ axion models that have no domain wall problem

Journal of High Energy Physics
We provide an exhaustive classification of three-family DFSZ axion models that have no cosmological domain wall problem. This result is obtained by making the Peccei-Quinn symmetry flavour dependent in certain specific ways, thus reinforcing a possible ...
Peter Cox, Matthew J. Dolan, Maaz Hayat, Andrea Thamm, Raymond R. Volkas   +4 more
doaj   +1 more source