Results 71 to 80 of about 1,667,560 (344)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Macro dark matter [PDF]

Monthly Notices of the Royal Astronomical Society, 2015
Dark matter is a vital component of the current best model of our universe, $ $CDM. There are leading candidates for what the dark matter could be (e.g. weakly-interacting massive particles, or axions), but no compelling observational or experimental evidence exists to support these particular candidates, nor any beyond-the-Standard-Model physics that
Jacobs, David M., Starkman, Glenn D., Lynn, Bryan W.   +2 more
openaire   +2 more sources

Signatures of Self-Interacting Dark Matter in the Matter Power Spectrum and the CMB

, 2018
We consider a self-interacting dark matter model in which the massive dark photon mediating the self-interaction decays to light dark fermions to avoid over-closing the universe.
Huo, Ran, Kaplinghat, Manoj, Pan, Zhen, Yu, Hai-Bo   +3 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Evidence for dynamical dark energy with an evolving Hubble constant

Astronomy & Astrophysics
Context. Hubble constant tension, together with the recent indications of dynamical dark energy proposed from the Dark Energy Spectroscopic Instrument (DESI) baryon acoustic oscillation (BAO) measurements, poses significant challenges for the standard ...
Wang Yi-Ying, Li Yin-Jie, Fan Yi-Zhong
doaj   +1 more source

Resonant dark matter

Journal of High Energy Physics, 2009
It is usually assumed that dark matter direct detection is sensitive to a large fraction of the dark matter (DM) velocity distribution. We propose an alternative form of dark matter-nucleus scattering which only probes a narrow range of DM velocities due to the existence of a resonance, a DM-nucleus bound state, in the scattering - resonant dark matter
Bai, Yang, Fox, Patrick J.
openaire   +2 more sources

Supersymmetric dark matter [PDF]

Nuclear Physics B - Proceedings Supplements, 2002
After a short introduction on some general implications of recent cosmological observations, we discuss the properties of relic neutralinos in connection with present experimental strategies for detecting WIMPs.
BOTTINO, Alessandro, DONATO, Fiorenza, FORNENGO, Nicolao, S. Scopel   +3 more
openaire   +3 more sources

Direct and indirect detection of dissipative dark matter

, 2014
We study the constraints from direct detection and solar capture on dark matter scenarios with a subdominant dissipative component. This dissipative dark matter component in general has both a symmetric and asymmetric relic abundance.
Fan, JiJi, Katz, Andrey, Shelton, Jessie
core   +1 more source

Measuring the dark matter velocity anisotropy in galaxy clusters [PDF]

, 2007
The Universe contains approximately 6 times more dark matter than normal baryonic matter, and a directly observed fundamental difference between dark matter and baryons would both be significant for our understanding of dark matter structures and provide
Allen, Bîrzan, Carlberg, Clowe, Cole, Diemand, Eke, Fabricant, Fukugita, Hansen, Hansen, Ikebe, Kaastra, Natarajan, Piffaretti, Pratt, R. Piffaretti, Rasia, S. H. Hansen, Sanderson, Sarazin, Sunyaev   +21 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source