Results 71 to 80 of about 242,972 (318)
Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Molecular Oncology, EarlyView.Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides +13 more
wiley +1 more source
The Macronova in GRB 050709 and the GRB-macronova connection
Nature Communications, 2016 A macronova is a clear signature that a short gamma-ray burst has been emitted by a compact-binary merger, but evidence of these events is so far scarce.
Zhi-Ping Jin +8 more
doaj +1 more source
Dark Matter Superfluidity [PDF]
Proceedings of 11th International Workshop Dark Side of the Universe 2015 — PoS(DSU2015), 2016 In these lectures I describe a theory of dark matter superfluidity developed in the last few years. The dark matter particles are axion-like, with masses of order eV. They Bose-Einstein condense into a superfluid phase in the central regions of galaxy halos.
openaire +5 more sources
International Journal of Modern Physics A, 1994 The hypothesis of an 'invisible' axion was made by Misha Shifman and others, approximately thirty years ago. It has turned out to be an unusually fruitful idea, crossing boundaries between particle physics, astrophysics and cosmology. An axion with mass of order 10-5 eV (with large uncertainties) is one of the leading candidates for the dark matter of
Pierre Sikivie, Pierre Sikivie
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
The multi-mode acoustic gravitational wave experiment: MAGE
Scientific Reports, 2023 The Multi-mode Acoustic Gravitational wave Experiment (MAGE) is a high frequency gravitational wave detection experiment. In its first stage, the experiment features two near-identical quartz bulk acoustic wave resonators that act as strain antennas with
William M. Campbell +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
, 2019 This is alternate explanation for the problem related with dark matter with out modifying gravity. Geometry of spacetime might work differently in large scale than we Think. just adding a simple term in the Einstein field equation, we can balance out the he problem related to dark matter and dark energy. Gravity is a long distance force and gets weaker
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Journal of Modern Physics, 2020 The prevailing cosmological constant and cold dark matter (LCDM) cosmic concordance model accounts for the radial expansion of the universe after the Big Bang. The model appears to be authoritative because it is based on the Einstein gravitational field equation.
Eckhardt, D.H., Garrido Pestaña, J.L.
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Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source