Results 81 to 90 of about 1,667,560 (344)
Foundations of Physics, 2021 AbstractAccording to the standard model of cosmology, $$\Lambda $$ Λ CDM, the mass-energy budget of the current stage of the universe is not dominated by the luminous matter that we are familiar with, but instead by some form of dark matter (and dark energy).
openaire +4 more sources
Weak Gravitational Lensing as a Method to Constrain Unstable Dark Matter
, 2010 The nature of the dark matter remains a mystery. The possibility of an unstable dark matter particle decaying to invisible daughter particles has been explored many times in the past few decades.
Wang, Mei-Yu, Zentner, Andrew R.
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
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Constraining primordial black holes as dark matter using AMS-02 data
European Physical Journal C: Particles and FieldsPrimordial black holes (PBHs) are the plausible candidates for the cosmological dark matter. Theoretically, PBHs with masses $$M_{\textrm{PBH}}$$ M PBH in the range of $$4\times 10^{14}\sim 10^{17}\,\textrm{g}$$ 4 × 10 14 ∼ 10 17 g can emit sub-GeV ...
Bing-Yu Su +5 more
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Cosmological implications of a Dark Matter self-interaction energy density
, 2010 We investigate cosmological constraints on an energy density contribution of elastic dark matter self-interactions characterized by the mass of the exchange particle and coupling constant.
C. Boehm +3 more
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Temporal and Spatial Chaos of RN-AdS Black Holes Immersed in Perfect Fluid Dark Matter [PDF]
, 2022 X. Y. Zhou +3 more
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Acta Physica Polonica B, 2013 We study the scenario where dark matter corresponds to a set of pseudo-Goldstone bosons, that we call dark pions, generated by the spontaneous breaking of a symmetry in the dark sector. As a concrete example, we consider an SU(N) SU(N) broken to the diagonal subgroup that remains an exact symmetry that ensures the stability of the dark pions, and ...
Bhattacharya, S., Melić, B., Wudka, J.
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