Results 111 to 120 of about 7,204,887 (298)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A closer look at dark matter production in exponential growth scenarios

Journal of High Energy Physics
We investigate a recently proposed non-thermal mechanism for dark matter production, in which a small initial dark matter (χ) number density undergoes exponential growth through scatterings with bath particles (ϕ) in the early universe (χϕ → χχ).
Disha Bhatia
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

A Dark-Matter Search Using the Final CDMS II Dataset and a Novel Detector of Surface Radiocontamination [PDF]

, 2012
Substantial evidence from galaxies, galaxy clusters, and cosmological scales suggests that ~85% of the matter of our universe is invisible. The missing matter, or "dark matter" is likely composed of non-relativistic, non-baryonic particles, which have ...
Ahmed, Zeeshan
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

A Dense Dark Matter Core of the Subhalo in the Strong Lensing System JVAS B1938+666

The Astrophysical Journal Letters
The nature of dark matter remains unknown, motivating the study of fuzzy/wave dark matter (FDM/ ψ DM) and self-interacting dark matter (SIDM) as alternative frameworks to address small-scale discrepancies in halo profiles inferred from observations. This
Lei Lei, Yi-Ying Wang, Qiao Li, Jiang Dong, Ze-Fan Wang, Wei-Long Lin, Yi-Ping Shu, Xiao-Yue Cao, Da-Neng Yang, Yi-Zhong Fan   +9 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Dark Matter Signals in the gamma-ray sky

EPJ Web of Conferences, 2014
Detection of gamma rays and cosmic rays from the annihilation or decay of dark matter particles is a promising method for identifying dark matter, understanding its intrinsic properties, and mapping its distribution in the universe.
Morselli Aldo
doaj   +1 more source

Dark Matter Bounds From 21-cm Cosmology

, 2022
reservedObserving the redshifted 21-cm line of atomic hydrogen allows us to test the early universe during the first phases of cosmic structure formation.
CIMA, FEDERICO
core  

Dark matter Phenomenology with Vector Portals [PDF]

, 2023
openThis thesis will consider theoretical constructions for dark matter candidates interacting with standard model particles via the exchange of a spin-one mediator.
CAVALLO, MATTIA
core