Results 91 to 100 of about 7,204,887 (298)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

How to Build an Empirical Speed Distribution for Dark Matter in the Solar Neighborhood

open access: yesThe Astrophysical Journal
The dark matter flux in a direct detection experiment depends on its local speed distribution. This distribution has been inferred from simulations of Milky Way–like galaxies, but such models serve only as proxies, given that no simulation directly ...
Tal Shpigel   +5 more
doaj   +1 more source

Caustics, Cold Flows, and Annual Modulation

open access: yesAdvances in Astronomy, 2011
We discuss the formation of dark matter caustics, and their possible detection by future dark matter experiments. The annual modulation expected in the recoil rate measured by a dark matter detector is discussed.
Aravind Natarajan
doaj   +1 more source

The distribution of inelastic dark matter in the Sun

open access: yesEuropean Physical Journal C: Particles and Fields, 2018
If dark matter is composed of new particles, these may become captured after scattering with nuclei in the Sun, thermalize through additional scattering, and finally annihilate into neutrinos that can be detected on Earth.
Mattias Blennow   +2 more
doaj   +1 more source

Dark matter distribution in the Draco dwarf from velocity moments [PDF]

open access: yes, 2004
We study the distribution of dark matter in the Draco dwarf spheroidal galaxy by modelling the moments of the line-of-sight velocity distribution of stars obtained from new velocity data of Wilkinson et al.
E. Lokas, G. Mamon, F. Prada
semanticscholar   +1 more source

Search for Dark Matter in Events with a Hadronically Decaying W or Z Boson and Missing Transverse Momentum in pp Collisions at s√=8  TeV with the ATLAS Detector [PDF]

open access: yes, 2013
A search is presented for dark matter pair production in association with a W or Z boson in pp collisions representing 20.3  fb−1 of integrated luminosity at s√=8  TeV using data recorded with the ATLAS detector at the Large Hadron Collider.
Alessandria, F   +999 more
core   +12 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Dark Matter: A Primer

open access: yesAdvances in Astronomy, 2011
Dark matter is one of the greatest unsolved mysteries in cosmology at the present time. About 80% of the Universe's gravitating matter is nonluminous, and its nature and distribution are for the most part unknown.
Katherine Garrett, Gintaras Duda
doaj   +1 more source

Collider Searches for Dark Matter (ATLAS + CMS)

open access: yesUniverse, 2018
Several searches for dark matter have been performed by the CMS and ATLAS collaborations, using proton-proton collisions with a center-of-mass energy of 13 TeV produced by the Large Hadron Collider. Different signatures may highlight the presence of dark
Nicolò Trevisani
doaj   +1 more source

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