Results 71 to 80 of about 111,737 (267)

Imprints of dark matter on black hole shadows using spherical accretions

European Physical Journal C: Particles and Fields, 2021
We study the possibility of identifying dark matter in the galactic center from the physical properties of the electromagnetic radiation emitted from an optically-thin disk region around a static and spherically symmetric black hole.
K. Saurabh, Kimet Jusufi
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Implications of the Intriguing Constant Inner Mass Surface Density Observed in Dark Matter Halos

Galaxies
It has long been known that the observed mass surface density of cored dark matter (DM) halos is approximately constant, independently of the galaxy mass (i.e., ρcrc≃constant, with ρc and rc being the central volume density and the radius of the core ...
Jorge Sánchez Almeida
doaj   +1 more source

Simulating Atomic Dark Matter in Milky Way Analogs

The Astrophysical Journal Letters, 2023
Dark sector theories naturally lead to multicomponent scenarios for dark matter where a subcomponent can dissipate energy through self-interactions, allowing it to efficiently cool inside galaxies.
Sandip Roy, Xuejian Shen, Mariangela Lisanti, David Curtin, Norman Murray, Philip F. Hopkins   +5 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A closer look at dark matter production in exponential growth scenarios

Journal of High Energy Physics
We investigate a recently proposed non-thermal mechanism for dark matter production, in which a small initial dark matter (χ) number density undergoes exponential growth through scatterings with bath particles (ϕ) in the early universe (χϕ → χχ).
Disha Bhatia
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A Dense Dark Matter Core of the Subhalo in the Strong Lensing System JVAS B1938+666

The Astrophysical Journal Letters
The nature of dark matter remains unknown, motivating the study of fuzzy/wave dark matter (FDM/ ψ DM) and self-interacting dark matter (SIDM) as alternative frameworks to address small-scale discrepancies in halo profiles inferred from observations. This
Lei Lei, Yi-Ying Wang, Qiao Li, Jiang Dong, Ze-Fan Wang, Wei-Long Lin, Yi-Ping Shu, Xiao-Yue Cao, Da-Neng Yang, Yi-Zhong Fan   +9 more
doaj   +1 more source