Results 51 to 60 of about 111,737 (267)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Physical properties of dark matter in galaxy U11454

Physical Sciences and Technology, 2020
In this paper physical characteristics of dark matter distribution in the spiral galaxy U11454 is explored using only well-known cored density profiles in the literature such as the pseudo-isothermal, Burkert, Einasto, exponential sphere, Beta and ...
K. Boshkayev, T. K. Konysbayev, E. B. Kurmanov, M. Muccino, G. Zhumakhanova   +4 more
doaj   +3 more sources

The Stellar Distribution in Ultrafaint Dwarf Galaxies Suggests Deviations from the Collisionless Cold Dark Matter Paradigm

The Astrophysical Journal Letters
Unraveling the nature of dark matter (DM) stands as a primary objective in modern physics. Here we present evidence suggesting deviations from the collisionless cold DM (CDM) paradigm.
Jorge Sánchez Almeida, Ignacio Trujillo, Angel R. Plastino   +2 more
doaj   +1 more source

The large cores of dark matter and globular clusters in AS1063: Possible evidence of self-interacting dark matter, or not

Astronomy & Astrophysics
Deep JWST images of AS1063 have revealed tens of thousands of globular clusters in the galaxy cluster AS1063. When compared with the lensing model based on the same JWST data, the distribution of globular clusters is shown to closely trace the ...
Diego J. M.
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Accurate Inner Stellar Density Slopes from Projected Surface Densities in Galaxies

The Astrophysical Journal
The inner slope of the three-dimensional stellar density in dwarf galaxies ( ${\rho }^{{\prime} }[0]$ ) is a sensitive probe of possible departures from the collisionless cold dark matter (CDM) paradigm, since cored stellar distributions ( ${\rho ...
Jorge Sánchez Almeida
doaj   +1 more source

Biasing and the distribution of dark matter haloes [PDF]

Monthly Notices of the Royal Astronomical Society, 1999
In hierarchical models of gravitational clustering, virialized haloes are biased tracers of the matter distribution. As discussed by Mo & White (1996), this bias is nonlinear and stochastic. They developed a model which allows one to write down analytic expressions for the mean of the bias relation, in the initial Lagrangian, and the evolved ...
Sheth, Ravi K., Lemson, Gerard
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Dark matter, black holes, and gravitational waves

Nuclear Physics B
The formation and growth of black holes can strongly influence the distribution of dark matter around them. I discuss here the different types of dark matter overdensities around black holes, including dark matter cusps, spikes, mounds, crests, and ...
Gianfranco Bertone
doaj   +1 more source

The distribution of inelastic dark matter in the Sun

European Physical Journal C: Particles and Fields, 2018
If dark matter is composed of new particles, these may become captured after scattering with nuclei in the Sun, thermalize through additional scattering, and finally annihilate into neutrinos that can be detected on Earth.
Mattias Blennow, Stefan Clementz, Juan Herrero-Garcia   +2 more
doaj   +1 more source