Results 41 to 50 of about 540,061 (294)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Journal of Information and Organizational Sciences, 2023 Conventionally, the Internet consists of three parts: Surface, Deep, and Dark Webs. In the last two decades, a massive increase in illicit activities took place on the different platforms of the Dark Web.
Faris Ali +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Frontiers in Physiology, 2023 Objectives: To characterize bedside 24-h patterns in light exposure in the Neonatal Intensive Care Unit (NICU) and to explore the environmental and individual patient characteristics that influence these patterns in this clinical setting.Methods: We ...
Isabelle A. Van der Linden +9 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Dark patterns ou le côté obscur du Nudge
, 2022 Il existe de nombreuses techniques comportementales plus ou moins subtiles, manipulatrices ou bienveillantes qui permettent de diriger le comportement d’une personne. Le terme de « nudge » (qu’on pourrait traduire par « coup de pouce ») a été popularisé
Hug, Dario
core
Shining a Light on Dark Patterns
, 2021 Dark patterns are user interfaces whose designers knowingly confuse users, make it difficult for users to express their actual preferences, or manipulate users into taking certain actions.
Luguri, Jamie +2 more
core +2 more sources
internetowy Kwartalnik Antymonopolowy i RegulacyjnyCelem artykułu jest prześledzenie różnego sposobu definiowania pojęcia dark patterns w doktrynie oraz orzecznictwie organów działających na terytorium Unii Europejskiej, szczególnie z polskiej perspektywy.
Damian Kazimierski
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Cold and Thermal Neutron Single Grating Dark-Field Imaging Extended to an Inverse Pattern Regime
Applied Sciences, 2022 Neutron dark-field imaging is a powerful tool for the spatially resolved characterization of microstructural features of materials and components. Recently, a novel achromatic technique based on a single absorption grating for the concurrent measurement ...
Matteo Busi +4 more
doaj +1 more source