Results 41 to 50 of about 3,890,266 (282)

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Privacy and Manipulation in the Platform Economy: An EU Framework for Regulating Dark Patterns

Platforms
Technological advancements have transformed the ways in which individuals interact with digital platforms, giving rise to data-driven ecosystems in which interface design plays a central role. Within these environments, dark patterns and manipulative and
Panagiotis Kitsos, Paraskevi Pappa
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Understanding Dark Patterns in Home IoT Devices [PDF]

, 2023
Internet-of-Things (IoT) devices are ubiquitous, but little attention has been paid to how they may incorporate dark patterns despite consumer protections and privacy concerns arising from their unique access to intimate spaces and always-on capabilities.
Choffnes, David, Gunawan, Johanna, Kowalczyk, Monica, Hartzog, Woodrow, Gunawan, Johanna T.; id_orcid, Dubois, Daniel J, Wilson, Christo, Choffnes, David R., Dubois, Daniel J.   +8 more
core   +1 more source

Towards Detecting Influential Members and Critical Topics from Dark Web Forums: A Data Mining Approach

Journal of Information and Organizational Sciences, 2023
Conventionally, the Internet consists of three parts: Surface, Deep, and Dark Webs. In the last two decades, a massive increase in illicit activities took place on the different platforms of the Dark Web.
Faris Ali, Randa Basheer, Mouhamad Kawas, Bassel Alkhatib   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Tales from the Dark Side: Privacy Dark Strategies and Privacy Dark Patterns [PDF]

Proceedings on Privacy Enhancing Technologies, 2016
Abstract Privacy strategies and privacy patterns are fundamental concepts of the privacy-by-design engineering approach. While they support a privacy-aware development process for IT systems, the concepts used by malicious, privacy-threatening parties are generally less understood and known.
Christoph Bösch 0001, Benjamin Erb, Frank Kargl, Henning Kopp, Stefan Pfattheicher   +4 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Próby zdefiniowania pojęcia dark patterns w doktrynie i aktywności organów państw członkowskich Unii Europejskiej

internetowy Kwartalnik Antymonopolowy i Regulacyjny
Celem artykułu jest prześledzenie różnego sposobu definiowania pojęcia dark patterns w doktrynie oraz orzecznictwie organów działających na terytorium Unii Europejskiej, szczególnie z polskiej perspektywy.
Damian Kazimierski
doaj   +1 more source

Characterizing light-dark cycles in the Neonatal Intensive Care Unit: a retrospective observational study

Frontiers in Physiology, 2023
Objectives: To characterize bedside 24-h patterns in light exposure in the Neonatal Intensive Care Unit (NICU) and to explore the environmental and individual patient characteristics that influence these patterns in this clinical setting.Methods: We ...
Isabelle A. Van der Linden, Esther M. Hazelhoff, Eline R. De Groot, Daniel C. Vijlbrief, Luc J. M. Schlangen, Yvonne A. W. De Kort, Marijn J. Vermeulen, Demy Van Gilst, Jeroen Dudink, Laura Kervezee   +9 more
doaj   +1 more source