Results 61 to 70 of about 540,061 (294)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Dark patterns in the post-cookie era: How interface regulation transforms digital advertising in the EU and the US

Цифровое право
The transition toward the so-called post-cookie era, driven by the decision of major technology companies to abandon third-party cookies, is significantly reshaping the architecture of digital advertising.
D. V. Korzh
doaj   +1 more source

Zombie contracts, dark patterns of design, and ‘documentisation’

Internet Policy Review, 2019
Standard form consumer contracts (SFCCs) are drafted by businesses and presented to consumers on a non-negotiable basis, commonly appearing as Terms of Service (ToS) agreements in the margins of many popular web pages.
Kristin B. Cornelius
doaj   +1 more source

Anomalous Coloration of Indo-Pacific Humpback Dolphins off Southern China

Journal of Marine Science and Engineering, 2023
The Indo-Pacific humpback dolphin is characterized by a particular ontogenic change in body color from dark gray at birth to pure white (or with a few dark-gray spots) after reaching adulthood.
Wenzhi Lin, Shenglan Chen, Ruiqiang Zheng, Agathe Serres, Binshuai Liu, Mingli Lin, Mingming Liu, Songhai Li   +7 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dark Patterns in Web User Interfaces: Toward an Incentive-Based Policy Approach Supplementing Legal Provisions

Wirtschaftsdienst, 2022
EU and national legislators in the EU continue to generate new regulations, striving to eliminate unfair design patterns in e-commerce, social media and other website user interfaces.
Torsten J. Gerpott
doaj   +1 more source

Shopping in the Dark

, 2022
Dark patterns are user interfaces designed to trick users into doing things they might not otherwise do. Human psychological insights are carefully exploited by designers to craft these patterns. This study investigates the relation between dark pattern recognition and platform choice.
Christof van Nimwegen, Jesse de Wit
openaire   +2 more sources

The Dark (Patterns) Side of UX Design [PDF]

Proceedings of the 2018 CHI Conference on Human Factors in Computing Systems, 2018
Interest in critical scholarship that engages with the complexity of user experience (UX) practice is rapidly expanding, yet the vocabulary for describing and assessing criticality in practice is currently lacking. In this paper, we outline and explore the limits of a specific ethical phenomenon known as "dark patterns," where user value is supplanted ...
Colin M. Gray, Yubo Kou, Bryan Battles, Joseph Hoggatt, Austin L. Toombs   +4 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source