Results 61 to 70 of about 3,890,266 (282)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Dark Patterns Cannot Stay in the Dark

, 2022
TurboTax reportedly tricked consumers into paying for tax filing services even if they were entitled to free tax filing services. And Google reversed a design change after receiving backlash for allegedly making search results and advertisements ...
Stephen, Karis, Jeong, Soojin, Sturtevant, Margaret   +2 more
core   +1 more source

Shopping in the Dark

, 2022
Dark patterns are user interfaces designed to trick users into doing things they might not otherwise do. Human psychological insights are carefully exploited by designers to craft these patterns. This study investigates the relation between dark pattern recognition and platform choice.
Christof van Nimwegen, Jesse de Wit
openaire   +2 more sources

The Dark (Patterns) Side of UX Design [PDF]

Proceedings of the 2018 CHI Conference on Human Factors in Computing Systems, 2018
Interest in critical scholarship that engages with the complexity of user experience (UX) practice is rapidly expanding, yet the vocabulary for describing and assessing criticality in practice is currently lacking. In this paper, we outline and explore the limits of a specific ethical phenomenon known as "dark patterns," where user value is supplanted ...
Colin M. Gray, Yubo Kou, Bryan Battles, Joseph Hoggatt, Austin L. Toombs   +4 more
openaire   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Dark patterns in the post-cookie era: How interface regulation transforms digital advertising in the EU and the US

Цифровое право
The transition toward the so-called post-cookie era, driven by the decision of major technology companies to abandon third-party cookies, is significantly reshaping the architecture of digital advertising.
D. V. Korzh
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

GDPR Dark Patterns in Cookie Consent: An Automated Study of High-Traffic Websites Accessed from Denmark

Future Internet
This paper examines how often GDPR-relevant dark patterns appear in cookie-consent banners and how often users receive a choice that is free and informed.
Christos Ntemkas, Laura Vieira Teixeira, Lejla Islami, Gaurav Choudhary, Nicola Dragoni   +4 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source