Results 71 to 80 of about 1,616,838 (296)

Dark Design Patterns: An End-User Perspective

Human Technology, 2020
The number of websites and mobile applications available is growing continually, as are the persuasive approaches to influence human behavior and decision making. Although designing for persuasion offers several potential benefits, recent developments expose various deceptive designs, that is, dark patterns, that utilize psychological factors to nudge ...
Maier, Maximilian, Harr, Rikard
openaire   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Plant volatiles, rather than light, determine the nocturnal behavior of a caterpillar. [PDF]

PLoS Biology, 2006
Although many organisms show daily rhythms in their activity patterns, the mechanistic causes of these patterns are poorly understood. Here we show that host plant volatiles affect the nocturnal behavior of the caterpillar Mythimna separata. Irrespective
Kaori Shiojiri, Rika Ozawa, Junji Takabayashi   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dark diversity in the dark: a new approach to subterranean conservation [PDF]

Subterranean Biology, 2019
When trying to predict biodiversity patterns, species absences in a community can be as informative as species presences. The concept of dark diversity considers geographical and ecological filters to set an expected species pool and to compare it with ...
Camile Sorbo Fernandes, Marco A. Batalha, Maria Elina Bichuette   +2 more
doaj   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Accomodating Solar and Atmospheric Neutrino Deficits, Hot Dark Matter, and a Double Beta Decay Signal

, 1994
Neutrino mass explanations of the solar and atmospheric neutrino deficits and a hot dark matter component require one of three patterns of those masses, as already pointed out by us.
Caldwell, David O., Mohapatra, Rabindra N.   +1 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Stable one-dimensional periodic waves in Kerr-type saturable and quadratic nonlinear media

, 2005
We review the latest progress and properties of the families of bright and dark one-dimensional periodic waves propagating in saturable Kerr-type and quadratic nonlinear media.
Akhmediev N N, Aleshkevich V, Aleshkevich V A, Alexey A Egorov, Bramati A, Buryak A V, Buryak A V, Carr L D, Carr L D, Duree G, Ferro P, Fil?chenkov S E, Gordon J P, Infeld E, Kamchatnov A M, Kartashov Y V, Kartashov Y V, Kartashov Y V, Kartashov Y V, Kartashov Y V, Kartashov Y V, Kartashov Y V, Kivshar Yu S, Kudashev V P, Lafortune S, Lluis Torner, Menyuk C R, Minardi S, Parker D F, Pavlenko V P, Petnikova V M, Shih M, Stegeman G I, Victor A Vysloukh, Yaroslav V Kartashov, Yuen H C   +35 more
core   +1 more source