Results 51 to 60 of about 1,616,838 (296)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Interference of surface plasmon polaritions controlled by the phase of incident light
, 2008 Interference patterns of surface plasmon polaritons(SPPs) are observed in the extraordinary optical transmission through subwavelength holes in optically thick metal plate. It is found that the phase of incident light can be transferred to SPPs.
Bouhelier A. +6 more
core +1 more source
Tales from the Dark Side: Privacy Dark Strategies and Privacy Dark Patterns [PDF]
Proceedings on Privacy Enhancing Technologies, 2016 Abstract Privacy strategies and privacy patterns are fundamental concepts of the privacy-by-design engineering approach. While they support a privacy-aware development process for IT systems, the concepts used by malicious, privacy-threatening parties are generally less understood and known.
Christoph Bösch +4 more
openaire +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Business & Information Systems Engineering, 2022 Kollmer, Tim, Eckhardt, Andreas
openaire +3 more sources
A cautionary tale: children, dark patterns and normative perspectives
Oñati Socio-Legal SeriesThis article explores the intersection of dark patterns — deceptive design practices that manipulate user behavior—with children’s digital experiences, examining how universal cognitive vulnerabilities intersect with context-specific susceptibilities ...
Vitória Oliveira
doaj +1 more source
Anomalous Coloration of Indo-Pacific Humpback Dolphins off Southern China
Journal of Marine Science and Engineering, 2023 The Indo-Pacific humpback dolphin is characterized by a particular ontogenic change in body color from dark gray at birth to pure white (or with a few dark-gray spots) after reaching adulthood.
Wenzhi Lin +7 more
doaj +1 more source
Coherent field emission image of graphene predicted with a microscopic theory
, 2011 Electrons in the mono-layer atomic sheet of graphene have a long coherence length of the order of micrometers. We will show that this coherence is transmitted into the vacuum via electric field assisted electron emission from the graphene edge.
Kreuzer, H. J. +2 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source