Results 51 to 60 of about 4,043,825 (280)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Frontiers in Physiology, 2023 Objectives: To characterize bedside 24-h patterns in light exposure in the Neonatal Intensive Care Unit (NICU) and to explore the environmental and individual patient characteristics that influence these patterns in this clinical setting.Methods: We ...
Isabelle A. Van der Linden +9 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
A cautionary tale: children, dark patterns and normative perspectives
Oñati Socio-Legal SeriesThis article explores the intersection of dark patterns — deceptive design practices that manipulate user behavior—with children’s digital experiences, examining how universal cognitive vulnerabilities intersect with context-specific susceptibilities ...
Vitória Oliveira
doaj +1 more source
Light dark matter showering under broken dark U(1) — revisited
Journal of High Energy Physics, 2019 It was proposed recently that different chiralities of the dark matter (DM) fermion under a broken dark U(1) gauge group can lead to distinguishable signatures at the LHC through shower patterns, which may reveal the mass origin of the dark sector.
Junmou Chen +4 more
doaj +1 more source
, 2022 Dark patterns are user interfaces designed to trick users into doing things they might not otherwise do. Human psychological insights are carefully exploited by designers to craft these patterns. This study investigates the relation between dark pattern recognition and platform choice.
Christof van Nimwegen, Jesse de Wit
openaire +2 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
internetowy Kwartalnik Antymonopolowy i RegulacyjnyZakupy przez Internet stają się codziennością dla coraz większej grupy osób, a wiele aktywności przenosi się do sieci. Upowszechnienie możliwości załatwiania bieżących spraw online powoduje także podniesienie poziomu wiedzy o zachowaniach konsumentów na ...
Damian Kazimierski
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source