Results 91 to 100 of about 268,213 (316)
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
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Franco Vaccari. Experiencing darkness towards Shamanism
Agathón, 2018 This paper examines one of the most symbolic and meaningful artworks by Franco Vaccari, Dark Sculpture, an artwork/temporary performance in which darkness becomes a play of presence-absence, inspired, both conceptually and visually, by the transition ...
Sergio Poggianella
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Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
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Journal of Nonlinear Mathematical Physics, 2001 Observing the Universe, astronomers have concluded that the motion of stars can not be accounted for unless one assumes that most of the mass in the Universe is carried on by a ``dark matter", so far impervious to all attempts at being detected. There is now a similar concept of ``dark energy".
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Karanlık Risalesi: Felsefeden Mistisizme
EskiyeniGenelde olumsuzlama cihetinden aydınlığın/nurun zıttı olarak kabul edilen karanlık, bu niteliği ile aydınlığın olmadığı bir durumu betimliyor olsa da onun nurun en parlak hâlini ifade ettiğini söylemek de mümkündür.
Mehmet Murat Karakaya
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La nuit chez les Inuit canadiens du haut Arctique : une nuit véritable, mais en trompe-l’œil
Bollettino della Società Geografica Italiana, 2019 For many observers, night in high latitudes can be summed up schematically as the seasonal astronomical phenomenon called “arctic night” and its spectacular alternation with its counterpoint, the so-called “midnight sun”.
Guy Bordin
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Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
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The Distribution of Radial Velocities of Dark H Markings Near Sunspots [PDF]
, 1934 H. W. Newton
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Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
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Proceedings of the National Academy of Sciences, 2014 The evidence for the dark matter (DM) of the hot big bang cosmology is about as good as it gets in natural science. The exploration of its nature is now led by direct and indirect detection experiments, to be complemented by advances in the full range of cosmological tests, including judicious consideration of the rich phenomenology of galaxies.
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