Results 91 to 100 of about 783,043 (296)

Darkness and gulliver2/phyB mutation decrease the abundance of phosphorylated BZR1 to activate brassinosteroid signaling in Arabidopsis

The Plant Journal, 2014
Light is essential for plant survival; as such, plants flexibly adjust their growth and development to best harvest light energy. Brassinosteroids (BRs), plant growth-promoting steroid hormones, are essential for this plasticity of development.
Bokyung Kim, Y. Jeong, Claudia Corvalán, S. Fujioka, Seoae Cho, T. Park, Sunghwa Choe   +6 more
semanticscholar   +1 more source

Dark Equations [PDF]

Journal of Nonlinear Mathematical Physics, 2001
Observing the Universe, astronomers have concluded that the motion of stars can not be accounted for unless one assumes that most of the mass in the Universe is carried on by a ``dark matter", so far impervious to all attempts at being detected. There is now a similar concept of ``dark energy".
openaire   +3 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Temperature and light requirements for germination of species of Velloziaceae from different Brazilian rocky outcrops

Acta Botânica Brasílica, 2018
Germination is the first step to successful plant establishment. The range of factors that promote germination varies among species. Light and temperature requirements for the germination of species of Velloziaceae were investigated.
Elisa Monteze Bicalho, Letícia A. Soares-da-Mota, Queila Souza Garcia   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The trehalose pathway in maize: conservation and gene regulation in response to the diurnal cycle and extended darkness

Journal of Experimental Botany, 2014
Summary Extended darkness induces a transient increase in sugars and trehalose pathway gene expression.
Clémence Henry, Samuel W. Bledsoe, Allison C. Siekman, Alec Kollman, B. Waters, R. Feil, M. Stitt, L. M. Lagrimini   +7 more
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Spatial representations of place cells in darkness are supported by path integration and border information

Frontiers in Behavioral Neuroscience, 2014
Effective spatial navigation is enabled by reliable reference cues that derive from sensory information from the external environment, as well as from internal sources such as the vestibular system.
Sijie Zhang, F. Schönfeld, Laurenz Wiskott, D. Manahan‐Vaughan   +3 more
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

History, trauma, demystification and narration in the novels Darkness and Animal kingdom by David Albahari [PDF]

Baština
The paper explores the issues of history, trauma, demystification, and narration present in the novels Darkness and Animal Kingdom, written by the Serbian writer David Albahari. It begins with an introduction that discusses Albahari's literary opus, with
Kovačević Darko M.
doaj   +1 more source