Results 141 to 150 of about 1,358,895 (382)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Into the darkness: Bruce Springsteen’s musical representations of the night [PDF]
, 2018 Into the darkness: Bruce Springsteen’s musical representations of the night Paper presented at the New Zealand Musicological Society Conference, 30 November - 2 December 2018, University of Canterbury, Christchurch, NZ.
Braae, Nick
core
Hormonal networks involved in apical hook development in darkness and their response to light
Frontiers in Plant Science, 2013 In darkness, the dicot seedlings produce an apical hook as result of differential cell division and extension at opposite sides of the hypocotyl. This hook protects the apical meristem from mechanical damage during seedling emergence from the soil.
M. Mazzella +3 more
semanticscholar +1 more source
Bufferbloat: Dark Buffers in the Internet [PDF]
, 2011 Jim Gettys, Kathleen Nichols
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Evolution of the Eye Transcriptome under Constant Darkness in Sinocyclocheilus Cavefish
Molecular biology and evolution, 2013 In adaptating to perpetual darkness, cave species gradually lose eyes and body pigmentation and evolve alternatives for exploring their environments. Although troglodyte features evolved independently many times in cavefish, we do not yet know whether ...
F. Meng +6 more
semanticscholar +1 more source
Primordial Black Holes and a Common Origin of Baryons and Dark Matter [PDF]
, 2021 J. García-Bellido +2 more
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The Dark Side of Interorganizational Relationships: An Integrative Review and Research Agenda [PDF]
, 2018 Nuno Oliveira, Fabrice Lumineau
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source