Results 11 to 20 of about 12,575 (207)

Anion-Controlled Structural Interconversion of Palladium Cages Enables Separations by Selective Guest Capture and Release. [PDF]

Angew Chem Int Ed Engl
We report a pair of interconvertible palladium(II) cages assembled from an asymmetric ligand, whose switching is triggered by specific counter‐anions, tetrafluoroborate (BF4−) and bis(trifluoromethanesulfonyl)imide (NTf2−). Their complementary guest preferences enable orthogonal, multi‐cycle catch‐and‐release, exemplified by the selective purification ...
Li Z, Ronson TK, McTernan CT.
europepmc   +3 more sources

Servicio de dispensación: interacción entre darunavir y quetiapina [PDF]

Farmacéuticos Comunitarios, 2022
Paciente varón de 52 años, con síndrome metabólico, virus de inmunodeficiencia humana (VIH), insomnio, trastorno de ansiedad generalizada, esquizofrenia y con medicación analgésica, que viene sufriendo numerosos episodios nocturnos de insomnio e ...
Damià Barris Blundell , Octavio Carrasco Naranjo   +1 more
doaj   +3 more sources

Virological outcomes with Bictegravir/Emtricitabine/Tenofovir alafenamide (B/F/TAF) in people previously treated with darunavir-based antiretroviral therapy. [PDF]

HIV Med
Abstract Background Darunavir‐based antiretroviral therapy (ART) is commonly used in people with HIV who experience adherence challenges and/or have complex resistance patterns. Changes in ART commissioning have led to an increased use of Bictegravir/Emtricitabine/Tenofovir alafenamide (B/F/TAF) in these populations despite limited real‐world outcome ...
Sheridan R, Osei-Kuffour Ekert Y, Campbell L, Zuckerman M, Hawkins S, Childs K, Post FA.   +6 more
europepmc   +2 more sources

Combating HIV resistance – focus on darunavir [PDF]

Therapeutics and Clinical Risk Management, 2008
Cécile L Tremblay11Department of Microbiology and Immunology, Centre Hospitalier de l’Université de Montréal, Montréal, CanadaAbstract: Darunavir is a second-generation protease inhibitor designed to ...
Cécile L Tremblay
doaj   +1 more source

Role of darunavir in the management of HIV infection [PDF]

HIV/AIDS: Research and Palliative Care, 2009
R Monica Lascar, Paul BennThe Mortimer Market Centre, Camden PCT, London WC1E 6JBAbstract: There is an ongoing need for potent antiretroviral therapies to deal with the increasing pool of treatment-experienced patients with multiple drug resistance.
R Monica Lascar, Paul Benn
doaj   +1 more source

Development and validation of UV-spectrophotometry method for quantitative determination of amorphous darunavir [PDF]

Разработка и регистрация лекарственных средств
Introduction. Darunavir as an effective antiretroviral drug is widely used in clinical practice, including for the treatment of pediatric patients, as well as pregnant women, and for personalized therapy.
M. A. Mandrik, I. A. Sadkovskii, E. D. Pinegina, L. A. Korol, I. I. Krasnuk   +4 more
doaj   +3 more sources

Profile of once-daily darunavir/cobicistat fixed-dose combination for the treatment of HIV/AIDS [PDF]

HIV/AIDS: Research and Palliative Care, 2016
Jordi Navarro, Adrian Curran Infectious Diseases Department, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain Abstract: Efficacy is the main objective of antiretroviral treatment and adherence is
Navarro J, Curran A
doaj   +1 more source

Virological Effectiveness of Dolutegravir Plus Darunavir in People with Multi-Drug-Resistant HIV: Data from the PRESTIGIO Registry [PDF]

Viruses
Background: Data on the use of dolutegravir (DTG) plus boosted darunavir (DRV/b) in people with 4-class drug-resistant HIV (4DR-PWH) are limited. This study assessed the virological effectiveness of DTG + DRV/b in this population using real-world data ...
Filippo Lagi, Michele Bellomo, Riccardo Lolatto, Filippo Ducci, Seble Tekle Kiros, Vincenzo Spagnuolo, Rebecka Papaioannu Borjesson, Tommaso Clemente, Leonardo Calza, Marcello Feasi, Emanuele Focà, Andrea Giacomelli, Roberto Gulminetti, Barbara Menzaghi, Antonella Castagna, on behalf of the PRESTIGIO Study Group   +15 more
doaj   +2 more sources

An Efficient Synthesis of the Bicyclic Darunavir Side Chain Using Chemoenzymatic Catalysis [PDF]

, 2022
Herein, we describe a chemoenzymatic synthesis of the bicyclic fragment of Darunavir. A ketoreductase was identified using metagenomic mining to catalyze a highly enantio- and diastereoselective dynamic kinetic resolution of a -ketolactone.
Jesmine, Lim, James, Finnigan, Paul, Riehl, Todd , Hyster, Simon, Charnock   +4 more
core   +1 more source

Efficacy and Durability of Dolutegravir- or Darunavir-Based Regimens in ART-Naïve AIDS- or Late-Presenting HIV-Infected Patients

Viruses, 2023
Background: Since limited data are available, we aimed to compare the efficacy and durability of dolutegravir and darunavir in advanced naïve patients. Methods: Retrospective multicenter study including AIDS- or late-presenting (def.
Massimiliano Fabbiani, Melissa Masini, Barbara Rossetti, Arturo Ciccullo, Vanni Borghi, Filippo Lagi, Amedeo Capetti, Manuela Colafigli, Francesca Panza, Gianmaria Baldin, Cristina Mussini, Gaetana Sterrantino, Damiano Farinacci, Francesca Montagnani, Mario Tumbarello, Simona Di Giambenedetto   +15 more
doaj   +1 more source