Servicio de dispensación: interacción entre darunavir y quetiapina [PDF]
Farmacéuticos Comunitarios, 2022 Paciente varón de 52 años, con síndrome metabólico, virus de inmunodeficiencia humana (VIH), insomnio, trastorno de ansiedad generalizada, esquizofrenia y con medicación analgésica, que viene sufriendo numerosos episodios nocturnos de insomnio e ...
Damià Barris Blundell +1 more
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Combating HIV resistance – focus on darunavir
Therapeutics and Clinical Risk Management, 2008 Cécile L Tremblay11Department of Microbiology and Immunology, Centre Hospitalier de l’Université de Montréal, Montréal, CanadaAbstract: Darunavir is a second-generation protease inhibitor designed to ...
Cécile L Tremblay
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Role of darunavir in the management of HIV infection
HIV/AIDS: Research and Palliative Care, 2009 R Monica Lascar, Paul BennThe Mortimer Market Centre, Camden PCT, London WC1E 6JBAbstract: There is an ongoing need for potent antiretroviral therapies to deal with the increasing pool of treatment-experienced patients with multiple drug resistance.
R Monica Lascar, Paul Benn
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Development and validation of UV-spectrophotometry method for quantitative determination of amorphous darunavir [PDF]
Разработка и регистрация лекарственных средствIntroduction. Darunavir as an effective antiretroviral drug is widely used in clinical practice, including for the treatment of pediatric patients, as well as pregnant women, and for personalized therapy.
M. A. Mandrik +4 more
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Profile of once-daily darunavir/cobicistat fixed-dose combination for the treatment of HIV/AIDS
HIV/AIDS: Research and Palliative Care, 2016 Jordi Navarro, Adrian Curran Infectious Diseases Department, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain Abstract: Efficacy is the main objective of antiretroviral treatment and adherence is
Navarro J, Curran A
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Conformational asymmetry of human immunodeficiency virus-1 protease flaps increases along the darunavir drug resistance pathway. [PDF]
Protein SciAbstract Under selective drug pressure, the structure and dynamics of HIV‐1 protease (PR) evolve to confer resistance to the drug. Here, we report on the conformational changes in PR flaps for drug‐resistance mutations using 19F nuclear magnetic resonance (NMR) spectroscopy.
Guerrero M +9 more
europepmc +2 more sources
An Efficient Synthesis of the Bicyclic Darunavir Side Chain Using Chemoenzymatic Catalysis [PDF]
, 2022 Herein, we describe a chemoenzymatic synthesis of the bicyclic fragment of Darunavir. A ketoreductase was identified using metagenomic mining to catalyze a highly enantio- and diastereoselective dynamic kinetic resolution of a -ketolactone.
Jesmine, Lim +4 more
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Darunavir Pharmacokinetics With an Increased Dose During Pregnancy. [PDF]
, 2020 BACKGROUND: This study aims to evaluate the pharmacokinetics of an increased dose of darunavir (800 mg twice daily) with 100 mg ritonavir during pregnancy and postpartum.
Smith, Elizabeth +9 more
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Characteristics and management of low-level viraemia in people living with HIV in a resource-limited setting: A multicentre retrospective study in Greece. [PDF]
HIV MedAbstract Objectives Low‐level viraemia (LLV) persists in some people living with HIV despite antiretroviral therapy, raising concerns about virologic failure. We assessed the characteristics, management and outcomes of LLV in Greece, where next‐generation sequencing, therapeutic drug monitoring and electronic adherence monitoring are unavailable ...
Leonidou L +13 more
europepmc +2 more sources
HIV Research & Clinical Practice, 2021 Background: Treatment during acute or early human immunodeficiency virus (HIV)-1 infection is associated with immunologic and virologic benefits. Objective: To evaluate darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) efficacy/safety ...
Keith Dunn +7 more
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