Results 171 to 180 of about 8,310 (209)

DAT1 methylation changes in alcohol-dependent individuals vs. controls

Journal of Psychiatric Research, 2015
The dopaminergic system plays a crucial role in the development of alcohol dependence. Regulation of the extracellular dopamine concentration is driven by dopamine transporter. Both, the expression and function of dopamine transporter, are influenced by chronic alcohol intake.
Andrzej, Jasiewicz, Błażej, Rubiś, Jerzy, Samochowiec, Iwona, Małecka, Aleksandra, Suchanecka, Marcin, Jabłoński, Anna, Grzywacz   +6 more
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Novelty Seeking and a Dopamine Transporter Gene Polymorphism (DAT1)

Biological Psychiatry, 1997
About 10 years ago, Cloninger defined the behavioral trait “novelty seeking” (NS) (Cloninger 1986, 1987). Two twin studies estimated the heritability of NS to be about 50% (Heath et al 1994; Stallings et al 1996). In early 1996, two papers reported significant associations between NS and a polymorphism of the type 4 dopamine receptor gene (DRD4 ...
Sullivan, Patrick F ., Fifield, Wendy J., Kennedy, Martin A., Mulder, Roger T., Sellman, J.Douglas, Joyce, Peter R.   +5 more
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Dopamine transporter (DAT1) VNTR polymorphism in 12 Indian populations

Neurological Sciences, 2009
The dopamine transporter (DAT1) is a membrane spanning protein that binds the neurotransmitter dopamine and performs re-uptake of dopamine from the synapse into a neuron. The gene encoding DAT1 consists of 15 exons spanning 60 kb on chromosome 5p15.32.
L V K S, Bhaskar, Kumarasamy, Thangaraj, Connie J, Mulligan, Samiksha, Wasnik, Amrita, Nandan, Varun Kumar, Sharma, Vishwas, Sharma, Alla Govardhana, Reddy, Lalji, Singh, Vadlamudi Raghavendra, Rao   +9 more
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DRD3 and DAT1 genes in schizophrenia: an association study

Journal of Psychiatric Research, 2000
To investigate the role of the dopamine receptor 3 (DRD3) and transporter 1 (DAT1) genes in schizophrenia or in modulating its phenotype.a Ser9Gly polymorphism in codon 9 of the DRD3 and a VNTR polymorphism in the DAT1genes were examined in two groups of schizophrenic patients, one of excellent neuroleptic responders (N=42) and one of nonresponders (N ...
R, Joober, A, Toulouse, C, Benkelfat, S, Lal, D, Bloom, A, Labelle, P, Lalonde, G, Turecki, G A, Rouleau   +8 more
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Population genetic study of the human dopamine transporter gene (DAT1)

Genetic Epidemiology, 1995
AbstractThe human dopamine transporter gene, DAT1, acts to transport released dopamine into presynaptic terminals of the brain. The possibility that the DAT1 gene plays a role in genetic diseases of the brain has led to studies of DAT1 in several psychiatric and neurological disorders. Previous sequence analysis of DAT1 revealed a 40‐bp repeat in the 3′
L A, Doucette-Stamm, D J, Blakely, J, Tian, S, Mockus, J I, Mao   +4 more
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DAT1 gene polymorphism in alcoholism: a family-based association study

Biological Psychiatry, 1999
The present study tests the hypothesis that the 9-repeat allele of the dopamine transporter gene (DAT1; SLC6A3) is more frequent in alcohol-dependent probands--and in particular those with severe withdrawal symptoms (seizures and/or delirium)--compared to nonalcoholics.To avoid stratification effects, the family-based association approach of Falk and ...
P, Franke, S G, Schwab, M, Knapp, M, Gänsicke, C, Delmo, P, Zill, M, Trixler, D, Lichtermann, J, Hallmayer, D B, Wildenauer, W, Maier   +10 more
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Association of the Dopamine Transporter Gene (DAT1) With Poor Methylphenidate Response

Journal of the American Academy of Child & Adolescent Psychiatry, 1999
This study attempted to relate the alleles of the D2 (DRD2), D4 (DRD4), and dopamine transporter (DAT1) genes to the behavioral outcome of methylphenidate therapy.African-American children with attention-deficit hyperactivity disorder were treated with methylphenidate in doses not in excess of 60 mg/day. The dosage was increased until behavioral change
B G, Winsberg, D E, Comings
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