Results 71 to 80 of about 3,746 (200)

Novelty Seeking and Stereotypic Activation of Behavior in Mice with Disruption of the Dat1 Gene [PDF]

Neuropsychopharmacology, 2005
Disruption of the dopamine (DA) transporter (Dat1) gene in mice leads to a 50% reduction or complete elimination of Dat1 expression in striatum of respective heterozygous (HZ) and knockout (KO) mice. Compared to wild-type (WT) controls, extracellular DA is increased approximately two- and five-fold in the mutants.
Vladimir M, Pogorelov, Ramona M, Rodriguiz, Megan L, Insco, Marc G, Caron, William C, Wetsel   +4 more
openaire   +2 more sources

Interactive effects of dopamine transporter genotype and aging on resting-state functional networks.

PLoS ONE, 2019
Aging and dopamine modulation have both been independently shown to influence the functional connectivity of brain networks during rest. Dopamine modulation is known to decline during the course of aging.
Christian Baeuchl, Hsiang-Yu Chen, Yu-Shiang Su, Dorothea Hämmerer, Manousos A Klados, Shu-Chen Li   +5 more
doaj   +1 more source

DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART).

PLoS ONE, 2012
Twin-studies suggest that a significant portion of individual differences in the propensity to take risks resides in people's genetic make-up and there is evidence that variability in dopaminergic systems relates to individual differences in risky choice.
Rui Mata, Robin Hau, Andreas Papassotiropoulos, Ralph Hertwig   +3 more
doaj   +1 more source

Updated peer review of the pesticide risk assessment of the active substance dichlorprop‐P and variant dichlorprop‐P‐2‐ethylhexyl

EFSA Journal, Volume 24, Issue 2, February 2026.
Abstract The conclusions of the EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Ireland and co‐rapporteur Member State, Poland, for the pesticide active substance dichlorprop‐P and the variant dichlorprop‐P‐2‐ethylhexyl and the assessment of applications for maximum
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Mark Egsmose, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Katrin Halling, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Silvia Mazzega, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza, Marija Blazevic   +49 more
wiley   +1 more source

The Selective Bromodomain and Extra‐Terminal Domain (BET) Inhibitor RVX‐208 Reduces Cocaine‐Seeking Behaviour and Alters Proteomic Pathways in the Nucleus Accumbens

Addiction Biology, Volume 31, Issue 1, January 2026.
Rats treated with the domain‐selective BET inhibitor RVX‐208 during a 2‐week forced abstinence period exhibited a reduction in cocaine‐seeking behaviour but not sucrose seeking or open field behaviour. This treatment effect was associated with proteomic changes in pathways relevant to dopaminergic and glutamatergic signalling in the nucleus accumbens ...
Tyler J. Sacko, Afshin Seyednejad, Jesse Engelhardt, Gregory C. Sartor   +3 more
wiley   +1 more source

DAT1 and alcohol use: differential responses to life stress during adolescence [PDF]

Criminal Justice Studies, 2015
Stressful life events can impact both substance use initiation and the quantity of substances consumed by adolescents; however, the effect of stress on substance use may be contingent on other factors including social support, peers, and genotype. DAT1, a polymorphic dopamine transporter gene, is one such factor that may be responsible for differential
openaire   +2 more sources

Untargeted and Targeted Liquid Chromatography‐Mass Spectrometry–Based Lipidomic Profiling Revealed a Potential Biomarker Panel to Distinguish Clinical Isolates of M. tuberculosis From Nontuberculous M. kansasii

Pulmonary Medicine, Volume 2026, Issue 1, 2026.
The rising incidence of nontuberculous mycobacteria (NTM) infections, particularly Mycobacterium kansasii (M. kansasii), and their overlapping clinical features with Mycobacterium tuberculosis (MTB) are leading to diagnostic ambiguity in tuberculosis‐endemic regions.
Meenakshi Chugh, Saif Hameed, Jitendra Singh, Zeeshan Fatima, Sarman Singh   +4 more
wiley   +1 more source

Mediators in the Relationship Between Attention‐Deficit/Hyperactivity Disorder Symptoms and Disordered Eating Symptoms: A Scoping Review

Mental Health Science, Volume 3, Issue 4, December 2025.
ABSTRACT Attention‐deficit/hyperactivity disorder (ADHD) is associated with disordered eating habits, and individuals with eating disorders show more ADHD symptoms. Little is known about the underlying mechanism of this association. In this scoping review, we aim to provide an overview of researched mediators in adults and discuss implications for ...
Lauris Annatha Mariam Auch, Andreas Riedel, Kerstin Gabriel Felleiter, Salvatore Corbisiero   +3 more
wiley   +1 more source

Interaction between serotonin 5-HT2A receptor gene and dopamine transporter (DAT1) gene polymorphisms influences personality trait of persistence in Austrian Caucasians

, 2010
We examined 89 normal volunteers using Cloninger's Temperament and Character Inventory (TCI). Genotyping the 102T/C polymorphism of the serotonin 5HT2A receptor gene and the ser9gly polymorphism in exon 1 of the dopamine D3 receptor (DRD3) gene was ...
Kindler, Jochen, Schloegelhofer, Monika, Fuchs, Karoline, Kasper, Siegfried, Leisch, Friedrich, Aschauer, Harald N, Schosser, Alexandra, Mossaheb, Nilufar, Scharl, Theresa, Kaufmann, Rainer M, Sieghart, Werner, Rainer M. Kaufmann, Monika Schloegelhofer, Nilufar Mossaheb, Karoline Fuchs, Theresa Scharl, Jochen Kindler, Friedrich Leisch, Harald N. Aschauer, Siegfried Kasper, Werner Sieghart, Alexandra Schosser   +21 more
core   +1 more source

Modulation of orbitofrontal response to amphetamine by a functional variant of DAT1 and in vitro confirmation [PDF]

Molecular Psychiatry, 2010
Modulation of orbitofrontal response to amphetamine by a functional variant of DAT1 and in vitro ...
Brotons, O., O'Daly, Owen, Guindalini, C., Howard, M., Bubb, J., Barker, G., Dalton, J., Quinn, J., Murray, R. M., Breen, G., Shergill, Sukhwinder   +10 more
openaire   +5 more sources