Results 131 to 140 of about 19,419,888 (317)

Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric central nervous system tumors

Nature Communications
The contribution of rare pathogenic/likely pathogenic (P/LP) germline variants to pediatric central nervous system (CNS) tumor development remains understudied. Here, we characterize the prevalence and biological significance of germline P/LP variants in
Ryan J. Corbett, Rebecca S. Kaufman, Shelly W. McQuaid, Zalman Vaksman, Saksham Phul, Miguel A. Brown, Jennifer L. Mason, Sebastian M. Waszak, Bo Zhang, Chuwei Zhong, Emily Blauel, Heena Desai, Ryan Hausler, Ammar S. Naqvi, Jessica M. Daggett, Alex Sickler, Evan C. Cresswell-Clay, Patricia J. Sullivan, Antonia Chroni, Zhuangzhuang Geng, Elizabeth M. Gonzalez, Yuankun Zhu, Allison P. Heath, Marilyn Li, Phillip B. Storm, Adam C. Resnick, Kara N. Maxwell, Kristina A. Cole, Angela J. Waanders, Miriam Bornhorst, Suzanne P. MacFarland, Jo Lynne Rokita, Sharon J. Diskin   +32 more
doaj   +1 more source

Data-Driven Chinese Walls.

, 2018
Security policy and access control models are often based on qualitative attributes, e.g. security labels, cryptographic credentials. In this paper, we enrich one such model, namely the Chinese Walls model, with quantitative attributes derived from data. Therefore, we advocate a data-driven approach that considers a quantitative definition of access we
Gulsum Akkuzu, Benjamin Aziz
openaire   +4 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Microstructure-informed constitutive modeling of granular media under multidirectional loading: From particle-scale to continuum

Communications Engineering
Simulating the response of granular materials under realistic loading scenarios is essential for ensuring the reliability of geotechnical infrastructure.
Nazanin Irani, Pegah Golestaneh, Mohammad Salimi, Merita Tafili, Yuha Park, Johannes Lederer   +5 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

DATA-DRIVEN RATE-OPTIMAL SPECIFICATION TESTING IN REGRESSION MODELS [PDF]

We propose new data-driven smooth tests for a parametric regression function. The smoothing parameter is selected through a new criterion that favors a large smoothing parameter under the null hypothesis.
Emmanuel Guerre, Pascal Lavergne
core  

Scoping the Skills Needs in the Social Sciences to Support Data-Driven Research

, 2022
This study, commissioned by the Economic and Social Research Council (ESRC), aims to help identify the skills needs of UK social science researchers to carry-out data-driven research and fully exploit the increasing volume of large and complex data ...
Allinson, Rebecca, Kolarz, Peter, Wain, Martin, Cimatti, Rita, Ferrie, Jo, Gallacher, Simon, Sutinen, Laura, Technopolis, MacInnes, John, Brown, Eleanor   +9 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source