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Data-Driven Edu Chatbots

Companion Proceedings of The 2019 World Wide Web Conference, 2019
There are many online courses and contents on the web, so each learner can find the best one and choose it. However, sometimes many online courses are poorly accessible due to the limits of the search engines on the web. The advent of intelligent systems, and online Chatbots, in particular, has brought improvement in various fields.
openaire   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Regional impacts of solar radiation modification on surface temperature and precipitation in Mainland Southeast Asia and the adjacent oceans

Scientific Reports
Solar radiation modification (SRM) has been proposed to temporarily reduce anthropogenic warming. This study presents an assessment of the regional impacts of SRM via solar dimming and stratospheric aerosol injection (SAI) on temperature and ...
Pornampai Narenpitak, Siriwat Kongkulsiri, Saifhon Tomkratoke, Sirod Sirisup   +3 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Machine learning-predicted chromatin organization landscape across pediatric tumors

Scientific Reports
Structural variants (SVs) are increasingly recognized as important contributors to oncogenesis through their effects on 3D genome folding. Recent advances in whole-genome sequencing have enabled large-scale profiling of SVs across diverse tumors, yet ...
Ketrin Gjoni, Shu Zhang, Rachel E. Yan, Bo Zhang, Daniel Miller, Jeffrey P. Greenfield, Adam Resnick, Nadia Dahmane, Katherine S. Pollard   +8 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Preparedness for Data-Driven Business Model Innovation: A Knowledge Framework for Incumbent Manufacturers

Applied Sciences
This study investigates data-driven business model innovation (DDBMI) for incumbent manufacturers, underscoring its importance in various strategic and managerial contexts. Employing topic modeling, the study identifies nine key topics of DDBMI.
Shailesh Tripathi, Nadine Bachmann, Manuel Brunner, Herbert Jodlbauer   +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Machine learning estimates for G20 subnational urban GHG emissions from 2000–2020

Scientific Data
Reliable, comparable greenhouse gas (GHG) emissions data at the subnational level remain scarce, despite growing expectations for cities and regions to lead on climate action. Inconsistent reporting, methodological variation, and limited coverage of self-
Ying Yu, Xuewei Wang, Diego Manya, Angel Hsu   +3 more
doaj   +1 more source