Results 91 to 100 of about 34,112,328 (298)
Artificial intelligence in combustion reaction kinetics: Methods and applications
Applications in Energy and Combustion ScienceCombustion is a complex process involving fluid dynamics, heat transfer and chemical kinetics, with significant environmental impacts due to greenhouse gas and pollutant emissions.
Chenyue Tao, Chengcheng Liu, Bin Yang
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Observation-driven configuration of complex software systems [PDF]
, 2015 The ever-increasing complexity of software systems makes them hard to comprehend, predict and tune due to emergent properties and non-deterministic behaviour.
Sage, Aled
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Statistics and data science unlock the predictive power of quantitative genetics
Frontiers in Plant SciencePlant breeding is undergoing a profound transition from an empirical and phenotype-centered discipline toward a predictive, inferential, and decision-oriented science. This transformation has been driven not only by the generation of large-scale genomic,
Osval A. Montesinos-López +15 more
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FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Data democratization: Empowering employees for data-driven innovation
, 2023 The exponentially growing usage and its benefits of digitizing data, as well as changes in data management practices, are continuously moderating the global economy and how organizations perform business operations.
Lokuge, Sachithra, Samarasinghe, Sasari
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Machine Learning Predictors of Extreme Events Occurring in Complex Dynamical Systems
Entropy, 2019 The ability to characterize and predict extreme events is a vital topic in fields ranging from finance to ocean engineering. Typically, the most-extreme events are also the most-rare, and it is this property that makes data collection and direct ...
Stephen Guth, Themistoklis P. Sapsis
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