Results 91 to 100 of about 1,555,240 (261)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

MagNet Challenge for Data-Driven Power Magnetics Modeling

IEEE Open Journal of Power Electronics
This article summarizes the main results and contributions of the MagNet Challenge 2023, an open-source research initiative for data-driven modeling of power magnetic materials.
Minjie Chen, Haoran Li, Shukai Wang, Thomas Guillod, Diego Serrano, Nikolas Forster, Wilhelm Kirchgassner, Till Piepenbrock, Oliver Schweins, Oliver Wallscheid, Qiujie Huang, Yang Li, Yu Dou, Bo Li, Sinan Li, Emmanuel Havugimana, Vivek Thomas Chacko, Sritharini Radhakrishnan, Mike Ranjram, Bailey Sauter, Skye Reese, Shivangi Sinha, Lizhong Zhang, Tom McKeague, Binyu Cui, Navid Rasekh, Jun Wang, Song Liu, Alfonso Martinez, Xinyu Liu, Chaoying Mei, Rui Zhao, Gaoyuan Wu, Hao Wu, Rui Zhang, Hao Song, Lie Zhang, Yibo Lu, Lijun Hang, Neha Rajput, Himanshu Bhusan Sandhibigraha, Neeraj Agrawal, Vishnu Mahadeva Iyer, Xiaobing Shen, Fanghao Tian, Qingcheng Sui, Jiaze Kong, Wilmar Martinez, Asier Arruti, Borja Alberdi, Anartz Agote, Iosu Aizpuru, Minmin Zhang, Xia Chen, Yuchen Dong, Duo Wang, Tianming Shen, Yan Zhou, Yaohua Li, Sicheng Wang, Yue Wu, Yongbin Jiang, Ziheng Xiao, Yi Tang, Yun-Shan Hsieh, Jian-De Li, Li-Chen Yu, Tzu-Chieh Hsu, Yu-Chen Liu, Chin-Hsien Hsia, Chen Chen, Alessio Giuffrida, Nicolo Lombardo, Fabio Marmello, Simone Morra, Marco Pasquale, Luigi Solimene, Carlo Stefano Ragusa, Jacob Reynvaan, Martin Stoiber, Chengbo Li, Wei Qin, Xiang Ma, Boyu Zhang, Zheng Wang, Ming Cheng, Wei Xu, Jiyao Wang, Youkang Hu, Jing Xu, Zhongqi Shi, Dixant Bikal Sapkota, Puskar Neupane, Mecon Joshi, Shahabuddin Khan, Bowen Su, Yunhao Xiao, Min Yang, Kai Sun, Zhengzhao Li, Reza Mirzadarani, Ruijun Liu, Lu Wang, Tianming Luo, Dingsihao Lyu, Mohamad Ghaffarian Niasar, Zian Qin, Syed Irfan Ali Meerza, Kody Froehle, Han Cui, Daniel Costinett, Jian Liu, Zhanlei Liu, Cao Zhan, Yongliang Dang, Yukun Zhang, Na Wang, Yiting Chen, Yiming Zhang, Chushan Li, Yinan Yao, Tianxiang Hu, Lumeng Xu, Yiyi Wang, Sichen Wang, Shuai Jiang, David Shumacher, Dragan Maksimovic, Ron S. Y. Hui, Johann W. Kolar, David J. Perreault, Charles R. Sullivan   +131 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Geometric neural operators (gnps) for data-driven deep learning in non-euclidean settings

Machine Learning: Science and Technology
We introduce Geometric Neural Operators (GNPs) for data-driven deep learning of geometric features for tasks in non-euclidean settings. We present a formulation for accounting for geometric contributions along with practical neural network architectures ...
B Quackenbush, P J Atzberger
doaj   +1 more source

State of Charge and State of Health Estimation in Electric Vehicles: Challenges, Approaches and Future Directions

Batteries
This critical review paper delves into the complex and evolving landscape of the state of health (SOH) and state of charge (SOC) in electric vehicles (EVs), highlighting the pressing need for accurate battery management to enhance safety, efficiency, and
Babatunde D. Soyoye, Indranil Bhattacharya, Mary Vinolisha Anthony Dhason, Trapa Banik   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source