Results 121 to 130 of about 34,112,328 (298)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

MagNet Challenge for Data-Driven Power Magnetics Modeling

IEEE Open Journal of Power Electronics
This article summarizes the main results and contributions of the MagNet Challenge 2023, an open-source research initiative for data-driven modeling of power magnetic materials.
Minjie Chen, Haoran Li, Shukai Wang, Thomas Guillod, Diego Serrano, Nikolas Forster, Wilhelm Kirchgassner, Till Piepenbrock, Oliver Schweins, Oliver Wallscheid, Qiujie Huang, Yang Li, Yu Dou, Bo Li, Sinan Li, Emmanuel Havugimana, Vivek Thomas Chacko, Sritharini Radhakrishnan, Mike Ranjram, Bailey Sauter, Skye Reese, Shivangi Sinha, Lizhong Zhang, Tom McKeague, Binyu Cui, Navid Rasekh, Jun Wang, Song Liu, Alfonso Martinez, Xinyu Liu, Chaoying Mei, Rui Zhao, Gaoyuan Wu, Hao Wu, Rui Zhang, Hao Song, Lie Zhang, Yibo Lu, Lijun Hang, Neha Rajput, Himanshu Bhusan Sandhibigraha, Neeraj Agrawal, Vishnu Mahadeva Iyer, Xiaobing Shen, Fanghao Tian, Qingcheng Sui, Jiaze Kong, Wilmar Martinez, Asier Arruti, Borja Alberdi, Anartz Agote, Iosu Aizpuru, Minmin Zhang, Xia Chen, Yuchen Dong, Duo Wang, Tianming Shen, Yan Zhou, Yaohua Li, Sicheng Wang, Yue Wu, Yongbin Jiang, Ziheng Xiao, Yi Tang, Yun-Shan Hsieh, Jian-De Li, Li-Chen Yu, Tzu-Chieh Hsu, Yu-Chen Liu, Chin-Hsien Hsia, Chen Chen, Alessio Giuffrida, Nicolo Lombardo, Fabio Marmello, Simone Morra, Marco Pasquale, Luigi Solimene, Carlo Stefano Ragusa, Jacob Reynvaan, Martin Stoiber, Chengbo Li, Wei Qin, Xiang Ma, Boyu Zhang, Zheng Wang, Ming Cheng, Wei Xu, Jiyao Wang, Youkang Hu, Jing Xu, Zhongqi Shi, Dixant Bikal Sapkota, Puskar Neupane, Mecon Joshi, Shahabuddin Khan, Bowen Su, Yunhao Xiao, Min Yang, Kai Sun, Zhengzhao Li, Reza Mirzadarani, Ruijun Liu, Lu Wang, Tianming Luo, Dingsihao Lyu, Mohamad Ghaffarian Niasar, Zian Qin, Syed Irfan Ali Meerza, Kody Froehle, Han Cui, Daniel Costinett, Jian Liu, Zhanlei Liu, Cao Zhan, Yongliang Dang, Yukun Zhang, Na Wang, Yiting Chen, Yiming Zhang, Chushan Li, Yinan Yao, Tianxiang Hu, Lumeng Xu, Yiyi Wang, Sichen Wang, Shuai Jiang, David Shumacher, Dragan Maksimovic, Ron S. Y. Hui, Johann W. Kolar, David J. Perreault, Charles R. Sullivan   +131 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Geometric neural operators (gnps) for data-driven deep learning in non-euclidean settings

Machine Learning: Science and Technology
We introduce Geometric Neural Operators (GNPs) for data-driven deep learning of geometric features for tasks in non-euclidean settings. We present a formulation for accounting for geometric contributions along with practical neural network architectures ...
B Quackenbush, P J Atzberger
doaj   +1 more source

State of Charge and State of Health Estimation in Electric Vehicles: Challenges, Approaches and Future Directions

Batteries
This critical review paper delves into the complex and evolving landscape of the state of health (SOH) and state of charge (SOC) in electric vehicles (EVs), highlighting the pressing need for accurate battery management to enhance safety, efficiency, and
Babatunde D. Soyoye, Indranil Bhattacharya, Mary Vinolisha Anthony Dhason, Trapa Banik   +3 more
doaj   +1 more source

Data-driven Methods in Inverse Problems.

, 2019
In this thesis on data-driven methods in inverse problems we introduce several new methods to solve inverse problems using recent advancements in machine learning and specifically deep learning. The main goal has been to develop practically applicable methods, scalable to medical applications and with the ability to handle all the complexities ...
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source