Results 131 to 140 of about 4,214,964 (288)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Addressing Concerns about Single Path Analysis in Business Cycle Turning Points: The Case of Learning Vector Quantization

Mathematics
Data-driven approaches in machine learning are increasingly applied in economic analysis, particularly for identifying business cycle (BC) turning points.
David Enck, Mario Beruvides, Víctor G. Tercero-Gómez, Alvaro E. Cordero-Franco   +3 more
doaj   +1 more source

Physics-/Model-Based and Data-Driven Methods for Low-Dose Computed Tomography: A survey. [PDF]

IEEE Signal Process Mag, 2023
Xia W, Shan H, Wang G, Zhang Y.
europepmc   +1 more source

Data-Driven and Hybrid Methods for Naval Applications

, 2020
The goal of this PhD thesis is to study, design and develop data analysis methods for naval applications. Data analysis is improving our ways to understand complex phenomena by profitably taking advantage of the information laying behind a collection of data. In fact, by adopting algorithms coming from the world of statistics and machine learning it is
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Deep Clinical Phenotyping of Schizophrenia Spectrum Disorders Using Data-Driven Methods: Marching towards Precision Psychiatry. [PDF]

J Pers Med, 2023
Habtewold TD, Hao J, Liemburg EJ, Baştürk N, Bruggeman R, Alizadeh BZ.   +5 more
europepmc   +1 more source

Data-driven Methods in Inverse Problems.

, 2019
In this thesis on data-driven methods in inverse problems we introduce several new methods to solve inverse problems using recent advancements in machine learning and specifically deep learning. The main goal has been to develop practically applicable methods, scalable to medical applications and with the ability to handle all the complexities ...
openaire   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

A Study on Using Transfer Learning to Utilize Information From Similar Systems for Data-Driven Condition Diagnosis and Prognosis

IEEE Access
Prognostics and health management (PHM) is a field of study that aims to diagnose the health of engineering systems and predict their future degradation.
Marcel Braig, Peter Zeiler
doaj   +1 more source