Results 101 to 110 of about 22,699,368 (374)

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Use of computer forensics in the digital curation of removable media [PDF]

, 2009
The purpose of this paper is to encourage the discussion of the potential place and value of digital forensics techniques when dealing with acquisitions on removable media in the field of digital curation.
Glisson, W.B.
core  

Researchers May Need Additional Data Curation Support

Evidence Based Library and Information Practice, 2019
A Review of: Johnston, L. R., Carlson, J., Hudson-Vitale, C., Imker, H., Kozlowski, W., Olendorf, R., & Stewart, C. (2018). How important are data curation activities to researchers? Gaps and opportunities for academic libraries.
Robin E. Miller
doaj   +1 more source

With Registered Reports Towards Large Scale Data Curation [PDF]

arXiv, 2020
The scale of manually validated data is currently limited by the effort that small groups of researchers can invest for the curation of such data. Within this paper, we propose the use of registered reports to scale the curation of manually validated data. The idea is inspired by the mechanical turk and replaces monetary payment with authorship of data
arxiv  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Data curation as collective action during COVID‐19

J. Assoc. Inf. Sci. Technol., 2020
In this commentary, the authors, an international group data curation researchers and educators, reflect on some of the challenges and opportunities for data curation in the wake of the COVID‐19 pandemic. We focus on some topics of particular interest to
K. Shankar, Wei Jeng, A. Thomer, Nicholas M. Weber, Ayoung Yoon   +4 more
semanticscholar   +1 more source

Community curation of bioinformatics software and data resources [PDF]

Briefings in Bioinformatics, 2019
Abstract The corpus of bioinformatics resources is huge and expanding rapidly, presenting life scientists with a growing challenge in selecting tools that fit the desired purpose. To address this, the European Infrastructure for Biological Information is supporting a systematic approach towards a comprehensive registry of tools and ...
Jon Ison, Hervé Ménager, Bryan Brancotte, Erik Jaaniso, Ahto Salumets, Tomáš Raček, Anna-Lena Lamprecht, Magnus Palmblad, Matúš Kalaš, Piotr Chmura, John M Hancock, Veit Schwämmle, Hans-Ioan Ienasescu   +12 more
openaire   +12 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Making open data work for plant scientists [PDF]

, 2013
Despite the clear demand for open data sharing, its implementation within plant science is still limited. This is, at least in part, because open data-sharing raises several unanswered questions and challenges to current research practices.
Alsheikh-Ali, Ball, Barrett, Bastow, Baxter, Brazma, Breeze, Brenchley, Charis Cook, Fernie, Hickman, International Arabidopsis Informatics Consortium, International Arabidopsis Informatics Consortium, Jonathan Moore, Leonelli, Nicholas Smirnoff, Rogers, Royal Society, Rustici, Ruth Bastow, Sabina Leonelli, The International Barley Genome Sequencing Consortium, Windram, Winter, Zimmermann   +24 more
core   +1 more source