Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Towards a generic research data management infrastructure [PDF]
, 2010 Until recent years, a focused and centralized strategy for the annotation, storage and curation of research data is something that has not been widely considered within academic communities.
Beard, Lorraine +9 more
core
Telescope Bibliographies: an Essential Component of Archival Data Management and Operations
, 2012 Assessing the impact of astronomical facilities rests upon an evaluation of the scientific discoveries which their data have enabled. Telescope bibliographies, which link data products with the literature, provide a way to use bibliometrics as an impact ...
Accomazzi, Alberto +3 more
core +1 more source
Central Curation of Glasgow Outcome Scale-Extended Data: Lessons Learned from TRACK-TBI
, 2021 Kim Boase +60 more
openalex +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
FEBS Open Bio, EarlyView.The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh +7 more
wiley +1 more source
Repository of NSF Funded Publications and Data Sets: "Back of Envelope" 15 year Cost Estimate [PDF]
, 2013 In this back of envelope study we calculate the 15 year fixed and variable costs of setting up and running a data repository (or database) to store and serve the publications and datasets derived from research funded by the National Science Foundation ...
Konkiel, Stacy +4 more
core +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
PQL: A Declarative Query Language over Dynamic Biological Schemata [PDF]
, 2002 We introduce the PQL query language (PQL) used in the GeneSeek genetic data integration project. PQL incorporates many features of query languages for semi-structured data.
Halevy, A. +3 more
core +1 more source
Text mining and social network analysis of data curation literature [PDF]
In support of data-intensive research and inquiry, data curation has been recognized as an emerging field of study and practice. The field has evolved rapidly, but knowledge structure and themes of diverse research on data curation is unclear.
Kim, Jeonghyun
core +1 more source