Results 121 to 130 of about 1,628,849 (334)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Difficulties and prospects of data curation for ADME <i>in silico</i> modeling

, 2023
Tsuyoshi Esaki, Kazuyoshi Ikeda
openalex   +2 more sources

Registry Data Storage and Curation [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2013
Megan, Johnston, Craig, Campbell, Rachel, Hayward, Mark, Lowerison, Vanessa K, Noonan, Ted, Pfister, Colleen, Maxwell, Claire Marie, Fortin, Eric E, Smith, Jean K, Mah, Moira K, Kapral, Nathalie, Jette, Tamara, Pringsheim, Lawrence, Korngut   +13 more
openaire   +4 more sources

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Data curation technologies and applications

大数据, 2019
Data curation is emerged in order to process,store and applied efficiency.Data curation processes active and continuous management the data through the whole lifecycle of it.And utilizing data curation techniques,data could be used to the maximum extent ...
Minghe YU, Tiezheng NIE, Guoliang LI
doaj  

The Nanomaterial Data Curation Initiative: A collaborative approach to assessing, evaluating, and advancing the state of the field [PDF]

, 2015
Christine Ogilvie Hendren, Christina M. Powers, Mark D. Hoover, Stacey L. Harper   +3 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Exploring the impact of data curation criteria on the observed geographical distribution of mosses. [PDF]

Ecol Evol, 2023
Ronquillo C, Stropp J, Medina NG, Hortal J.   +3 more
europepmc   +1 more source

History DMP: managing data for historical research [PDF]

A poster describing the work of the JISC-funded History DMP project, produced for display at a JISC Managing Research Data Programme meeting in Nottingham on 2nd December 2011 and at the 7th International Digital Curation Conference in Bristol on 5-6th ...

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