Results 121 to 130 of about 1,958,447 (346)
FEBS Open Bio, EarlyView.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
wiley +1 more source
Curation of chemogenomics data [PDF]
Nature Chemical Biology, 2015 Alexander Tropsha +2 more
openaire +3 more sources
Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification
FEBS Open Bio, EarlyView.Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski +13 more
wiley +1 more source
D3.2 Cost Concept Model and Gateway Specification [PDF]
, 2014 This document introduces a Framework supporting the implementation of a cost concept model against which current and future cost models for curating digital assets can be benchmarked.
Ashley, Kevin +10 more
core
PLoS ONEData curators play an important role in assessing data quality and take actions that may ultimately lead to better, more valuable data products. This study explores the curation practices of data curators working within US-based data repositories.
Lisa R Johnston +8 more
doaj +1 more source
Planning Data Management Education Initiatives: Process, Feedback, and Future Directions
Journal of eScience Librarianship, 2014 Educating researchers in sound data management skills is a hot topic in today’s data intensive research world. Librarians across the country and the world are taking the lead in offering this training to their campus research communities.
Christopher Eaker
doaj +1 more source
The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise
FEBS Open Bio, EarlyView.Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji +3 more
wiley +1 more source
, 2010 Data management is a growing area of service for data archives and university libraries alike. How do data professionals support researchers in their efforts to manage, disseminate, and preserve their research data? What are the roles of librarians and data archivists?
openaire +1 more source
Data Curation Profiles Symposium Panel on Opportunities in the Data Curation Landscape
, 2012 The Data Curation Profiles Symposium was hosted by Purdue Libraries and was held on September 24 2012. The participants on the panel on opportunities in the data curation landscape were Chuck Thomas (IMLS via Skype), Rachel Frick (DLF), and Dr. Helen Tibbo (UNC-Chapel Hill).
Thomas, Charles +2 more
openaire +4 more sources
Interaction of class III cellobiose dehydrogenase with lytic polysaccharide monooxygenase
FEBS Open Bio, EarlyView.The activity of lytic polysaccharide monooxygenase (LPMO) is supported by its auxiliary enzyme cellobiose dehydrogenase (CDH). The catalytic activity of both enzymes is coupled by electron transfer and a cyclic cascade generating substrates for both enzymes – hydrogen peroxide for LPMO and oxidized and non‐oxidized cellobiose and cello‐oligosaccharide ...
Angela Giorgianni +4 more
wiley +1 more source